Diego Balboa

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🤩💪 Out now! 3D regulatory hubs in sex determination

With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social

1️⃣ METALoci – explore #3DGenome 🧬
2️⃣ Non-coding region controlling Fgf9 🧩
3️⃣ Meis genes = new key players 🌟

👉 rdcu.be/e5sm2

1/n Bluetorial 👇

Progress!

You still have 3 days to apply to the postdoc positions available in my lab 😀
🔬Come and work with us 🔬

Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV and hMPV by targeting conserved epitopes.

By isolating immune cells from pediatricians, researchers in #ScienceTranslationalMedicine employed rational design to engineer cocktails of monoclonal antibodies that neutralize #RSV and #metapneumovirus in rodents without generating resistance. https://scim.ag/4rZKe8J

Losing sleep over #iPSC transgene silencing after differentiation?
Same here.

Bright in iPSCs.
Gone after differentiation.

Our paper in @cp-cellstemcell.bsky.social maps what actually keeps expression on👇
www.cell.com/cell-stem-ce...
🔗 Free access (50 days):
www.sciencedirect.com/science/auth...

Thrilled to share the primary focus of my PhD thesis work, now out in @science.org today!

We developed Trikines — engineered cytokines that reconfigure receptor complex assembly to reshape signaling directly in endogenous immune cells.

t.co/UCixfysaUl

Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.

Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.

Jennifer Doudna’s $1 Billion Plan To Bring Gene Editing To The Masses Crispr’s ability to cut genetic code like scissors has just started to turn into medicines. Now, gene editing pioneer Jennifer Doudna wants to build an entire ecosystem to bring these treatments mains...

“The best that I can do in terms of making the next breakthrough or discovery is not to do it by myself, but to enable other scientists to do it”
— Jennifer Doudna

www.forbes.com/sites/amyfel...

We‘re looking for a motivated Master student to join our team!

Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬

Then please apply!
#optogenetics #metabolism #devbio #hESCs

Please RT. Thank you!🙏

Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis"

www.biorxiv.org/content/10.6...

Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo

Improving rigor in stem cell research: New study in Stem Cell Reports highlights gaps in reporting and shows how implementing ISSCR standards can strengthen reproducibility in human stem cell studies. https://ow.ly/7PiO50Yey7Y

Cell Press | The Gairdner Foundation | SickKids Foundation

Here is a robust biochemical & functional difference between young and old mammalian cells:

- The fraction of new amino acids incorporated into proteins.

The difference is consistent, quantitative, cell-type specific, and deeply intriguing.

What aging mechanisms cause it ?

1/

One thing I just learned from Bad Bunny is that very careful preparation and attention to every detail, moment by moment, in crafting a presentation can do wonders

Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes - Nature Metabolism The authors use Perturb-seq analysis in human pancreatic islet beta cells, as well as in vivo and in vitro analyses, to identify potential therapeutic targets for type 2 diabetes, including ZZEF1, whi...

RESEARCH | J Nan, X He, X Liu, Y Cao et al (SJTU, CN)

A combination of Perturb-seq, in vitro and in vivo analyses in mice and human islet beta cells identifies therapeutic targets for type 2 diabetes🧪

www.nature.com/articles/s42...

The lab turns 4 ⌛️🐭⏳👤

Science happened…

More productive & fun than ever.

Huge thanks to the amazing lab members who make it all possible!!

(Light-sheet microscope movie by Berta Cava Cami)

Join us this week for the next exciting VGZT session! 🎉

🗓️ Thursday, February 5th
⏰ 9:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET

Our speakers are
👉 Evgeny Kvon (@evgenykvon.bsky.social)
👉 Silas Boye Nissen (on X: @SilasBoyeNissen)

See you on Thursday! 👋

Behind the paper: “Spatially organized cellular communities shape functional tissue architecture in the pancreas” - the Node Behind the paper story from Alejo Torres Cano on their recent paper describing how spatially organized cellular communities shape functional tissue architecture in the pancreas.

👀 Check out @the-node.bsky.social where
@alejotorrescano.bsky.social (first author) share
#behindthepaper stories about our recent paper
⤵️

Behind the paper: “Spatially organized cellular communities shape functional tissue architecture in the pancreas” thenode.biologists.com/behind-the-p...

Bar chart showing the number of electoral democracies by age globally in 2024. Most countries are not democracies (91 out of 179 countries with data); and most countries that are democratic are younger than a lifetime. For example, 19 countries have been electoral democracies for between 1–18 years. The data source is V-Dem (2025). The chart is licensed CC BY to Our World in Data.

To some young people living in democracies, authoritarianism may seem like a long-forgotten part of their country’s history.

(🧵1/23) First month of 2026: complete✅! Many papers coming from CIRTN scientists, including works from the labs of Drs Bruin, Lynn, Estall, Ferdaoussi, Fullerton, Hull-Meichle, Pepper, Korbutt, Levings, Lim, Mulvihill, Rabasa-Lhoret, Riddell, Rutter, Tsai, Woo and Verchere! 📝

Lab-made islet cell implants sail through diabetes trials, but are they ready yet? - Nature Biotechnology First-in-human studies provide hope that islet replacement therapies derived from stem cells will prove safe and effective in people with type 1 diabetes, but hurdles remain.

First-in-human studies provide hope that islet replacement therapies derived from stem cells will prove safe and effective in people with type 1 diabetes, but hurdles remain www.nature.com/articles/s41...
rdcu.be/e1x9M

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

We're testing AlphaGenome.

It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.

Congrats to @avsecz.bsky.social and the team for this landmark publication.

www.nature.com/articles/s41...

Online now! A comprehensive overview of pluripotent stem cell lines for clinical use.166 clinical hPSC lines available for licensing and distribution, including 11 used in clinical trials, with information on consent, regulation, and characterization. https://ow.ly/tQ2j50XMw30

ISSCR

What's larger, a protein or its templating mRNA ?

> The mRNA is much larger.

⬛ 𝐀 𝐬𝐞𝐧𝐬𝐞 𝐨𝐟 𝐬𝐜𝐚𝐥𝐞 -- 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐢𝐧𝐭𝐮𝐢𝐭𝐢𝐨𝐧 & 𝐜𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 -- 𝐢𝐬 𝐚 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐞𝐧𝐚𝐛𝐥𝐞𝐫 𝐨𝐟 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡.

The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

🚨 Job Alert! 🚨

We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇

abo.rekrytointi.com/paikat/index...

#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

Bringing African ancestry into cellular neuroscience Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.

Most iPSC lines come from European donors. Now, two teams in Africa are studying neurodevelopment and neurodegeneration using iPSCs and organoids from African donors.

By Lauren Schenkman

www.thetransmitter.org/cellular-neu...

If you are looking for a position in a microscopy facility, we will also be recruiting very soon, be in touch as well :)

A 13-lined ground squirrel in Minnesota. Stock photo.

In the summer months, when food is plentiful, 13-lined ground squirrels excrete urea as a waste product. In the winter, while hibernating, they collaborate with their gut microbes to make use of urea’s carbon to form acetate, a source of energy. In PNAS: https://ow.ly/UvNl50XTxlR

Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...

Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l