Dr Sarah Mitchell

“One man’s trash is another man’s treasure” 😬

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism
Great work from @lydialynch.bsky.social lab and colleagues
www.nature.com/articles/s42...

www.biorxiv.org/content/10.1...

Super cool!

Congrats @asaelroichman.bsky.social excited to read!!

Camilla is a horse face.

Wrong Sarah Mitchell!

Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50...

Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world.

Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...

Oooh that Elon felon one is good!

Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...

... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:

doi.org/10.1038/s415...

3/3

Renowned geneticist Francis Collins retires from NIH, urging 'respect' for embattled workers Dr. Francis Collins, a renowned geneticist, and former longtime director of the National Institutes of Health, is retiring from the government agency and urging “respect” for its embattled workers.

"When you hear about patients surviving stage 4 cancer because of immunotherapy, that was based on NIH research over many decades. When you hear about sickle cell disease being cured because of CRISPR gene editing, that was built on years of research supported by NIH"

apnews.com/article/nih-...

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

Shocking.

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...

U.S. early-career researchers struggling amid chaos Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

A whole generation of early career scientists and physician-scientists, including colleagues and myself, are particularly vulnerable to these funding freezes and cuts, with jobs and careers depending on federal grants.

#IDsky
#Medsky
#Episky

www.science.org/content/arti...

This is an example of research that will save lives but would be blocked by the current administration:

Great to see AFAR! We need more of this! @afar.org

So if Musk doesn’t run DOGE, and DOGE isn’t a real government agency, then no one has to listen to Musk or do what the DOGE bros tell them to do, right?

Donald Trump and Elon Musk are trying to cut funding for cancer and rare disease research.

A federal judge temporarily blocked the cuts in some states, but this fight is not over.

We can’t let them play politics with our health.

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

This!!!!

How much Elon Musk makes from the government a day: $8 million.

How much a senior on Social Security gets a day: $65

Guess which budget Musk and Trump want to cut?

Government isn't a business. The goal isn't to save money. Success isn't measured by budget surplus.

The goal is to spend money, investing in society. Every dollar spent on education, healthcare, and science is an investment in our collective wellbeing.

❤️❤️ to the generous donor who believes in research and science education ❤️❤️ Best news I’ve heard today…

bsky.app/profile/mbls...

Ugh. I hope they don’t pull funding from funded K99 MOSIAC peeps. It would be terrible if they suddenly couldn’t get their R00 phase money.

This is the front page of a fraudulent research article that purported to show a link between vaccines and autism. The word "RETRACTED" is written across it in large red letters. Wikipedia: On 28th February 1998, a fraudulent research paper by physician Andrew Wakefield and twelve coauthors, titled "Ileal-Lymphoid-Nodular Hyperplasia, Non-Specific Colitis, and Pervasive Developmental Disorder in Children", was published in the British medical journal The Lancet.[1] The paper falsely claimed causative links between the measles, mumps, and rubella (MMR) vaccine and colitis and between colitis and autism. The fraud involved data selection, data manipulation, and two undisclosed conflicts of interest.

Today is Retraction Day, when we observe the anniversary of the retraction (Feb. 2, 2010) of the fraudulent paper that purported to show a link between vaccines and autism. 🧪#medsky

The entire website for the NIH Office of Research on Women's Health (ORWH) is very nearly stripped bare. This is so, so devastating. orwh.od.nih.gov/research/fun...

Home page now: orwh.od.nih.gov

Archive: web.archive.org/web/20241216...

Beautiful cat! Love her coat!