Jack Holcombe

@rorylcooper.bsky.social 👀?

🙏

Never pee near scope, ends badly

Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk

Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️‍🩹

Full info below, and please share! 🫶🏻

bit.ly/467TO0M

Have a look at our latest preprint, "Nuclear plasticity regulates macrophage phagocytic capacity in vivo".

#apoptoticbodies #efferocytosis #nucleus #Drosophila #macrophages #mechanoresponse #InVivo #LiveImaging

doi.org/10.64898/202...

Very cool, congrats!

Amazing city, even better lab!

Congrats! So Beautiful!!

Aaand... my first cover!!

RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬

🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬

This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!

www.findaphd.com/phds/project... 🧪

Lovely to see this, congrats @senapati.bsky.social !

Visceral signaling of post-ingestive malaise directs memory updating in Drosophila Consolidation is a time when labile memories transition to a stable form. Malaise learning in Drosophila reveals consolidation to also permit memory updating. Flies taught to associate one of two odor...

@senapati.bsky.social latest and greatest! Charly Treiber on board too. Over and out.

www.biorxiv.org/content/10.1...

A painting of a very large hog.

AWS is down, post hog

These ancient bumblebees were found with their pollen source Insects have long pollinated plants, but evidence of ancient pairing is rare. Fossils now show bees and linden trees goes back 24 million years.

Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby.

The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.

#Paleontology #NationalFossilDay

🧪🏺

New at @sciencenews.bsky.social

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...

Black and white portrait of John Gurdon, 1971

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

Thankyou so much Helena!

Firm linked to Baroness Michelle Mone must pay £122m after breaching Covid PPE contract, judge rules The government wins its case against PPE Medpro - part of a consortium led by Baroness Mone's husband - after it supplied non-compliant gowns in 2020.

Bloody lovely

www.bbc.co.uk/news/live/cy...

Was listening to the bbc coverage of this yesterday and was thinking the same! I need to read the paper itself but would be interesting to see why skin and not some other accessible tissue?

Figure 1: Fluorophore intensity in the Drosophila blastoderm (n.c. 14). Comparison of (A) green and (B) red fluorescence intensity using the same intensity scaling in n.c. 14. The fluorescence signal did not saturate. Shown are single imaging planes. Normalised histograms of fluorescence intensity for green (C) and red (D) fluorophores averaged across at least n=3 embryos per line. Scale bars = 20 μm

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

I wrote something on developmental biology and disability and put it up on the node last night:

thenode.biologists.com/developmenta...

I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!

Thank you for sharing this!

Thanks so much!

Thanks so much Iwan, was absolutely lovely to catch up! Hopefully see you around soon!

Some amazing talks but highlights for me were David Bilder on innate immune-tumour interactions, @jackholcombe.bsky.social ‘s PhD prize tour de force and exciting and beautiful data and new tools to look at basement membrane and clotting hot out of @stramerlab.bsky.social

This is awesome Girish! Congrats to the whole team!

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

Can you guess what time my talk started?

Thanks!

Such an amazing experience sharing science with a wonderful community! Thanks so much 🧬🔬@edrc2025.bsky.social @fly-eds.bsky.social