Ghina BADIH

@ghinabadih.bsky.social and Laetitia Kurzawa from CytoMorphoLab concluded that "contractile forces direct the chiral swirling of cells".

The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?

Contractile forces direct the chiral swirling of minimal cell collectives | PNAS Chirality is a conserved biological feature with critical implications in tissue morphogenesis and embryonic development. In culture, multicellular...

@ghinabadih.bsky.social 's paper on cell chirality is now out : www.pnas.org/doi/10.1073/... 🥳

Grateful to everyone who contributed to this work and made it possible! @alex-schaef.bsky.social Ben Vianay Pauline Smilovici @lblanchoin.bsky.social @manuelthery.bsky.social Laëtitia Kurzawa

For all the twists, turns, and forces behind the swirl, you can sneak a peak at the full article, which I am thrilled to announce is now available @pnas.org: www.pnas.org/doi/10.1073/...

Furthermore, with the help of a heterotypic system, we point out the more contractile cell in the duo as the choreographer of the biased swirl, setting both its rhythm and direction.

Our results show that even in such a minimalistic configuration, endothelial cells spontaneously display a robust, rightward bias that can be modulated by the magnitude of the contractile forces produced by the doublets.

During my PhD, we tried address this question by simplifying a cell collective to its bare minimum: a doublet.

Yes, the cells constituting our body do have handedness - an intriguing phenomenon that orchestrates large-scale collective motions indispensable for morphogenesis and embryonic development. But, how do cell collectives make such an important decision with much ease and (pre)determination?!

Go right or left? A question that we encounter very often in our daily lives, and while our decision may sometimes be hindered by the fear of making a mistake, cells DO NOT HESITATE!!! They swirl with the confidence of someone who’s always RIGHT… or LEFT!!!

🔬 From JCB’s July issue (rupress.org/jcb/issue/22...): a PtK2 cell plated on a micropattern and injected with low doses of soluble actin (orange) and tubulin (blue) in order to generate speckles along the corresponding filaments. From @manuelthery.bsky.social group (rupress.org/jcb/article/...).

And it’s FINALLY OUT 🎉
The new work from Schaeffer, Théry and colleagues provides revolutionary insights into the processes underlying #centrosome positioning in adherent cells.
Check out the article @jcb.org to unlock the full story behind these new results: hubs.la/Q03hQjdn0!
@drs88.bsky.social