Shweta Nandakumar

Our new preprint is live!🎉
Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions.

On bioRxiv now!

Congrats @dyuthisreekumar.bsky.social

www.biorxiv.org/content/10.6...

I loved Scott and Kip in Gamechanger. Happy Reading 🙌🙂

😍😍😍😍

Forgot about this too and my favorite fic updated last night 😭I need to know what happens 😭
Thank you A03 team for all your work🙌🙌

Exciting new preprint from @schaedellab.bsky.social 🔬🧫
Vimentin network architecture and mechanics is mediated by cytosolic regulation.
I can't help but marvel at the beautiful vimentin network images😍😍
I am so happy it's finally out😍😍❤️ Congratulations @dyuthisreekumar.bsky.social 👏🎉

Yes ! Orbital is one of the reads atop my TBR for the next year. So far I have heard only good things about the book. I picked up 'Dear Thief' by chance and wolfed it down in one sitting. So good. Words, such beautiful words ❤️

I am also hardcore Klunatic, so another favorite of mine from this year was the sequel "Somewhere beyond the Sea" by Tj Klune. So good. His new book also comes out in April 2026.

If you don't mind a bit of angst, betrayal, words so heart-wrenchingly perfect that they seem like poetry, you should read 'Dear Thief' by Samantha Harvey.

Paclitaxel induces NM2-dependent cellular contraction independent of microtubule acetylation in live cells

www.biorxiv.org/content/10.6...

Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read!

Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase.

www.biorxiv.org/content/10.6...

Happy holidays ✨🎄

Now online! Structural basis of microtubule-mediated signal transduction

PhD Position in Biophysics Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

PhD Position in Biophysics #ScienceJobs #AcademicSky

📢Internships on cellular nematics!

🔬Come for the pretty images, stay for the cool physics: each project combines in vitro experiments with advanced microscopy and image analysis.

📧Feel free to DM or email me with any questions.

I like this movie, but a friend of mine likes to complain about the obvious stitching artifacts. I'll try harder next time, Michael. Vimentin (orange) and ER (blue) in an overnight acquisition.

😍😍😍

iPS cell-derived cardiac myocytes (heart muscle cells) typically beat about once per second, so I usually speed up the movies I post; otherwise, scrollers might miss the action. But every now and then, a cell looks like this in real time. #CellBiology

Go right or left? A question that we encounter very often in our daily lives, and while our decision may sometimes be hindered by the fear of making a mistake, cells DO NOT HESITATE!!! They swirl with the confidence of someone who’s always RIGHT… or LEFT!!!

Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end https://www.biorxiv.org/content/10.1101/2025.11.17.688760v1

An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...

Dick is one of the most thoughtful folks in cell biology--this is a must read for anyone interested in microtubules!

Playing around with @kwolbachia.bsky.social 's LUT manager plugin. Absolutely love the campfire LUT🔥 😍#microtubulemonday

Absolutely love both the tools :) The LUT manager is so much fun. Thanks 😀

Beautiful 😍😍

Same. The withdrawal is real !!!

Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D https://www.biorxiv.org/content/10.1101/2025.09.18.677142v1

Thank you so much 🙌🙂

Have you ever wondered how microtubules withstand and respond to mechanical stress in cells?

Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.

Here's some more exciting new news from the microtubule world ✨Great work from @marianattom.bsky.social the @schaedellab.bsky.social showing how MAP65-1/PRC-1 reinforce microtubules under mechanical stress.
Look at them microtubule arrays in plant cells 😍 ( To quote Verstappen, "Simply lovely")

Thank you so much ❤️ your comment made my day 🙌🙌❤️

A big thank you to my amazing PI Laura Schaedel, my colleagues @schaedellab.bsky.social , Mirko Wieczorek, Constantin Albrecht, @stefandiezlab.bsky.social , @manuelthery.bsky.social and the team of Ludger Santen😀🧵 (9/9).