Adrián Candelas

Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...

Programmed cell revival from imminent cell death enhances tissue repair and regeneration | The EMBO Journal imageimageThe ability of cells to recover after the initiation of cell death pathways is only little understood. This study challenges the dogma of irreversible cell death by characterizing a programm...

On the first day they resurrected 🥰

www.embopress.org/doi/full/10....

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.

First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social

rdcu.be/ezBl7

Collage of three photos: 1) the EMBL TREC fleet is driving next to the coast; 2) three scientists are taking samples on a grassy field; 3) a scientist is cryo-preserving samples. Behind her, there is a lab bench with equipment visible.

With its scientific expeditions, EMBL is pioneering a new era of field-based molecular life sciences. 🚌🔬

Supported by the Klaus Tschira Stiftung & many partners, these ‘labs on wheels’ enable the study of life in context across Europe, with a view to global impact. 🌍🧬

www.embl.org/news/connect...

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...

Tissue-like multicellular development triggered by mechanical compression in archaea The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

That's dramatic (and cool): "archaea species can also form multicellular tissue–like structures when compressive forces are applied... ... These results establish multicellularity as a feature of all three domains of life" www.science.org/doi/10.1126/...

I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...

Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!

Fast & Fair peer review: a pilot study demonstrating feasibility of rapid, high-quality peer review in a biology journal Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...

Interested to read the ins and outs of our Fast & Fair peer review experiment? Read the preprint at bit.ly/424d9x3 #fastandfairpeerreview

Origin of metazoans Roscoff (Bretagne), France, June 16-20, 2025Deadline for application: March 4, 2025

Monod Conference "Origin of metazoans": fossils, genomes, cell biology, gene regulation, development, and more.

Join us in Roscoff for an exceptional speaker line-up and stunning venue!

🗓️Abstract deadline: March 4.

Register and share!
www.insb.cnrs.fr/fr/origin-me...

Beautiful Alfredo ! 😍😍 congrats !!

New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...

If you are interested, you can find more about our published work on this fascinating cells:
1. About polarization: rupress.org/jcb/article/...
2. About asymmetric division: journals.biologists.com/dev/article-...
Thanks also to my PhD mentors, Committee, Jury, and labmates ! 😊

🎉 I am honored to receive the 2024 PhD Thesis Prize from French Society of Cell Biology !🎉

Deeply grateful to the Society for recognizing our work on understanding how niche cells drive polarization and asymmetric division of human hematopoietic progenitors.
sbcf.fr/en/newslette...

Haha indeed !

I love that quote 🤍

except in the light of evolution.

H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells Cell persistence and senescence are distinct states of proliferative arrest induced by cancer therapy, with persister cells being characterized by the silencing of inflammatory genes through the heter...

I am thrilled to finally share our work on persister cancer cells: we identify distinctive features and actionable #vulnerabilities ⚡️of persister cancer cells (#DTP), and provide mechanistic insight into their low #inflammatory activity:
aacrjournals.org/cancerres/ar...

How roots and shoots communicate through stressful times When plants face an environmental stress such as water deficit, soil salinity, high temperature, or shade, good communication between above- and belowground organs is necessary to coordinate growth and development. Various signals including hormones, peptides, proteins, hydraulic signals, and metabolites are transported mostly through the vasculature to distant tissues. How shoots and roots synchronize their response to stress using mobile signals is an emerging field of research. We summarize recent advances on mobile signals regulating shoot stomatal movement and root development in response to highly localized environmental cues.

Yeah! I think here the point is to destroy the idea that neural networks are unique in their function to do “effective” responses upon environmental cues. Even bacteria can present not-so-far types of structural configuration. In plants, this idea is more accepted.

www.cell.com/trends/plant...

What better way to start on this social network?

www.embopress.org/doi/epdf/10....

Our January cover shows a reconstructed synapse from a cryo-electron tomogram of cultured hippocampal neurons expressing a SNAP-25 mutant, using CryoVesNet developed by Amin Khosrozadeh, Benoît Zuber et al. (https://buff.ly/4h0DjGN).
JCB's January issue is here ✨ https://buff.ly/3ZZLqwE

Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi Cells reorganize in space and time to move and divide - complex behaviors driven by their internal cytoskeleton. While we have substantial knowledge of the molecular parts and rules of cytoskeletal as...

New preprint from Alex Long, Tim Stearns, Jessica Feldman, Lillian Fritz-Laylin and colleagues! Chytrids are neat, understudied and ecologically important as frog pathogens. Shown here, they also remodel their centrioles during cilia disassembly prior to mitosis:
www.biorxiv.org/content/10.1...