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I haven’t spent enough time here, but this week Stripe Press launched our newest book, Maintenance: of Everything, Part One, by the inimitable Stewart Brand: press.stripe.com/maintenance-...

About the unglamorous yet civilizationally important work of maintenance and repair.

I have a good feeling I will! :) I've been enjoying titles from Stripe Press since the start.

I fondly go back a lot to the copy of "The Art of Doing Science and Engineering" that you gave me all those years ago. All the work you get up to at Stripe Press inspires me!

Big congrats on the launch!! My copy just arrived today and looking forward to diving in.

🌐Our new LMB website is live!🌐
Fresh design, better navigation, same first-class science.
Take a look around ➡️ mrclmb.ac.uk

new year, new job?!

Exciting postdoc position opening in my lab at the Wellcome Sanger Institute. Fully funded by CRUK

sanger.wd103.myworkdayjobs.com/en-US/Wellco...

find out more at www.coelho-lab.com

WRN inhibitors are being tested in patients with MSI cancers. How do tumours adapt to WRN inhibition, and can therapy stay ahead of resistance?

Our latest preprint investigates how MSI tumours evolve under pressure from WRN inhibition. Highlights below.

tinyurl.com/GenGenFaculty

GenGen is hiring group leaders! If you want to generate data at scale to train the next generation of AI models to make molecular biology predictive and programmable, we want to hear from you.

Generating long deletions across the genome with pooled paired prime editing screens Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...

New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.

🔗 biorxiv.org/content/10.1...

A short thread (by Juliane Weller)👇

🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.

Big, beautiful trees!!

SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.

www.biorxiv.org/content/10.1...

GitHub - allydunham/dnacomb: CLI tool for flexibly parsing structured sequence reads into count tables and comparing them to expected libraries CLI tool for flexibly parsing structured sequence reads into count tables and comparing them to expected libraries - allydunham/dnacomb

We've been screening across many DNA construct structures with variable number/size of interesting regions - e.g. spacer, extension and barcode for prime editing. There wasn't a widely used tool to process these complex structured reads so I ended up developing github.com/allydunham/d....

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

In our latest paper, I wrote 2 supplementary notes (5 and 6) to briefly recap classical models, starting with Armitage&Doll and moving onto models with different types of clonal expansions. Some readers may find them of interest. [4/4] static-content.springer.com/esm/art%3A10...

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Sperm sequencing reveals extensive positive selection in the male germline - Nature A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

depmap miner logo

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.

Start mining data now: dataminer.depmap.sanger.ac.uk

Researchers take first steps to creating synthetic human genomes | Wellcome Scientists are developing technology to create the first synthetic human chromosome. The ability to write large genomes could transform our understanding of health.

Scientists are taking the first steps towards the first synthetic human genome.

We’re proud to announce £10 million funding for the SynHG project.

Learn more ⤵️
wellcome.org/news/researc...

Leveraging data as a patient–scientist: frustrations and opportunities - Nature Reviews Nephrology The transition from data scientist to patient–scientist has given me new perspectives into clinical research and strengthened my commitment to open science. Although limitations on data availability h...

I wrote a short piece on how becoming an IgA Nephropathy patient has changed my perspective on biomedical research, developing an appreciation for the challenges in data interpretability & availability and the importance of patient engagement www.nature.com/articles/s41...

Cancer Plasticity Atlas To Improve Cancer Therapies

Cancer Plasticity Atlas To Improve Cancer Therapies

#HelmholtzMunich joins @sangerinstitute.bsky.social & @parse.bsky.social to build the Cancer Plasticity Atlas, using #AI & single-cell data to model therapy response.

👉 t1p.de/13ifi

@fabiantheis.bsky.social
@mgarnett.bsky.social

#CancerResearch

Pioneering cancer plasticity atlas will help predict response to cancer therapies Utilising novel organoid perturbation and Artificial Intelligence (AI) platforms, the aim is to create a comprehensive dataset to fuel foundational drug discovery models and cancer research.

Announcing a new collaboration with @parse.bsky.social @www.helmholtz-munich.de to develop a #Cancer Plasticity Atlas.

The reference map will help predict the effect of cancer drugs - where resistance might develop and where to target future treatment efforts.

www.sanger.ac.uk/news_item/pi...

That’s all for #VariantEffect25! This was my first time live sketching a conference, it was a really fun and interesting experience. The science was fantastic, i learnt so much!!

Big thanks to everyone who shared any of my sketches or spoke to me about them, i really appreciate it.

Check this out if you're interested in #crispr #baseeditor. Congratulations Cansu for creating this wonderful tool.

Check out the first session for the upcoming GRC conference on synthetic lethality in oncology www.grc.org/synthetic-le.... Top flight speakers - Simon Powell (MSK), Chris Lord (ICR), and plenary talk from William Sellers (Broad Inst.). What a start! It's not too late to register.

🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor

I'm incredibly grateful to have been selected as one of the best talks at the Downing College Postgraduate Conference 2025, an honour I shared with brilliant Ms Herrick-Doyle, from Oxford, Lincoln College, whose presentation was truly inspiring.
@downingcollege.bsky.social

Learn about the future of synthetic lethality in oncology at the upcoming Gordon Research Conference. This is the inaugural meeting and WOW what a lineup! We have a truly phenomenal program, with top speakers from academia and industry. Check it out at the link below.
www.grc.org/synthetic-le....

Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social

Building AI models or the data to train them?

Core funding of >$130M a year for a faculty of ~30.

www.nature.com/naturecareer...

acrobat.adobe.com/id/urn:aaid:...

pls RT!

We’re looking for Computational Scientists to join our team in advancing cutting-edge research at the intersection of spatial genomics and AI.

Check it out:
lnkd.in/ezruccHF
lnkd.in/e2siGM_9

Excited to announce that we're recruiting a Staff scientist at the Sanger Institute to investigate drug resistance mechanisms in cancer using gene editing.

Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...