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Researchers take first steps to creating synthetic human genomes | Wellcome Scientists are developing technology to create the first synthetic human chromosome. The ability to write large genomes could transform our understanding of health.

Scientists are taking the first steps towards the first synthetic human genome.

We’re proud to announce £10 million funding for the SynHG project.

Learn more ⤵️
wellcome.org/news/researc...

Leveraging data as a patient–scientist: frustrations and opportunities - Nature Reviews Nephrology The transition from data scientist to patient–scientist has given me new perspectives into clinical research and strengthened my commitment to open science. Although limitations on data availability h...

I wrote a short piece on how becoming an IgA Nephropathy patient has changed my perspective on biomedical research, developing an appreciation for the challenges in data interpretability & availability and the importance of patient engagement www.nature.com/articles/s41...

Cancer Plasticity Atlas To Improve Cancer Therapies

Cancer Plasticity Atlas To Improve Cancer Therapies

#HelmholtzMunich joins @sangerinstitute.bsky.social & @parse.bsky.social to build the Cancer Plasticity Atlas, using #AI & single-cell data to model therapy response.

👉 t1p.de/13ifi

@fabiantheis.bsky.social
@mgarnett.bsky.social

#CancerResearch

Pioneering cancer plasticity atlas will help predict response to cancer therapies Utilising novel organoid perturbation and Artificial Intelligence (AI) platforms, the aim is to create a comprehensive dataset to fuel foundational drug discovery models and cancer research.

Announcing a new collaboration with @parse.bsky.social @www.helmholtz-munich.de to develop a #Cancer Plasticity Atlas.

The reference map will help predict the effect of cancer drugs - where resistance might develop and where to target future treatment efforts.

www.sanger.ac.uk/news_item/pi...

That’s all for #VariantEffect25! This was my first time live sketching a conference, it was a really fun and interesting experience. The science was fantastic, i learnt so much!!

Big thanks to everyone who shared any of my sketches or spoke to me about them, i really appreciate it.

Check this out if you're interested in #crispr #baseeditor. Congratulations Cansu for creating this wonderful tool.

Check out the first session for the upcoming GRC conference on synthetic lethality in oncology www.grc.org/synthetic-le.... Top flight speakers - Simon Powell (MSK), Chris Lord (ICR), and plenary talk from William Sellers (Broad Inst.). What a start! It's not too late to register.

🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor

I'm incredibly grateful to have been selected as one of the best talks at the Downing College Postgraduate Conference 2025, an honour I shared with brilliant Ms Herrick-Doyle, from Oxford, Lincoln College, whose presentation was truly inspiring.
@downingcollege.bsky.social

Learn about the future of synthetic lethality in oncology at the upcoming Gordon Research Conference. This is the inaugural meeting and WOW what a lineup! We have a truly phenomenal program, with top speakers from academia and industry. Check it out at the link below.
www.grc.org/synthetic-le....

Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social

Building AI models or the data to train them?

Core funding of >$130M a year for a faculty of ~30.

www.nature.com/naturecareer...

acrobat.adobe.com/id/urn:aaid:...

pls RT!

We’re looking for Computational Scientists to join our team in advancing cutting-edge research at the intersection of spatial genomics and AI.

Check it out:
lnkd.in/ezruccHF
lnkd.in/e2siGM_9

Excited to announce that we're recruiting a Staff scientist at the Sanger Institute to investigate drug resistance mechanisms in cancer using gene editing.

Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...

How does a young person who loves both science and art decide on a career? Seattle Hub's Dr. Jonas Koeppel has a theory.
@alleninstitute.bsky.social
@jonaskoeppel.bsky.social
@chanzuckerberg.bsky.social
@sudpinglay.bsky.social
brotmanbaty.org/news/promisi...

Yeah! Top it off with a fried egg and some spring onions and you’ve got a tasty, economic meal right there.

Glad to see Indomie getting the recognition on this list! Top tier instant noodle!

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Bluetorial: Women, courage, and leadership

What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid - Nature Communications Retinoic acid is known to be effective against bone marrow metastatic neuroblastoma cells, but not primary tumors. Here, authors discover that bone morphogenetic protein signaling is responsible for d...

Can we treat cancer by forcing cancer cells to differentiate?

Retinoids are unique cancer drugs that, according to textbooks, make cancer cells mature and lose their malignant behavior. In our new paper, we reveal there’s more to how they really work… 1/n
www.nature.com/articles/s41...

New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le....

Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.

Darwin Tree of Life Impact Assessment This form is used to share information within DToL about case studies, ongoing research, and funding awards that demonstrate the impact the Darwin Tree of Life consortium project has had on Global and...

Do you use Darwin Tree of Life (DToL) genomes for your work or grant applications? If so, can you please fill out this form? docs.google.com/forms/d/e/1F... We are gathering info on how DToL genomes are used. It will help us raise money to continue producing publicly available high-quality genomes.

Sequencing by Expansion (SBX) — a novel, high-throughput single-molecule sequencing technology Remarkable advances in high-throughput sequencing have enabled major biological discoveries and clinical applications, but achieving wider distribution and use depends critically on further improvemen...

Roche SBX preprint out

www.biorxiv.org/content/10.1...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)

Randomizing the human genome by engineering recombination between repeat elements We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...

Francis Crick Lecture Shankar Balasubramanian Herchel Smith Professor of Medicinal Chemistry, University of Cambridge The DNA Quadruplex Helix Wednesday 19 February at 10 am Max Perutz Lecture Theatre and Zoom Details on the LMB Website Sponsored by AstraZeneca

We’re thrilled to be welcoming Shankar Balasubramanian for the first LMB Named Lecture of 2025!
On Wednesday 19th February, Shankar will join us to deliver the Francis Crick Lecture on ‘The DNA Quadruplex Helix’
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
#LMBSeminar

The Week in Bio #34. Research highlights from the week including randomisation of a super-enhancer, catalytic LYTACs from Lycia Therapeutics and de novo design of binders for snake venom. Link below.

Freddie Whiting in our group wrote this thoughtful commentary on @karunamdphd.bsky.social's recent paper that explored cell state changes and plasticity in colorectal cancer evolution. He concludes we need to better understand epigenetic control of plasticity. authors.elsevier.com/c/1kTSf5Sx5g...

Enhancer scrambling strategy

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...

Our ChromBPNet preprint out!

www.biorxiv.org/content/10.1...

Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/

Glad to share one of the happiest moment in my life. I’d like to thank my dear supervisor @mgarnett.bsky.social for his incredible support, encouragement and guidance, and all the Garnett team for their friendship. I am extremely grateful for this remarkable journey 🥂
#phdone