Clement Tsui PhD 🇭🇰 🇨🇦

Tick-borne viruses: discovery, clinical aspects, influencing factors and control - Nature Reviews Microbiology Pathogenic tick-borne viruses (TBVs) are a global threat to public and veterinary health. In this Review, Cao and colleagues highlight the diversity of the tick virome, review human and animal TBV pathogens, outline clinical features of human TBV infections, describe factors impacting ticks and TBV spread, and discuss the need for integrated One Health control strategies.

Pathogenic tick-borne viruses (TBV) are a threat to public and animal health. A Review in Nature Reviews Microbiology article discusses the tick virome's diversity, TBV pathogens, clinical features of human infections, and the need for integrated One Health control strategies.🔒

Tiered Access for AIxBio Governance Parallel proposals target training data and model access to reduce biosecurity risk

Tiered Access for AIxBio Governance doi.org/10.59350/svd...

Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide https://www.biorxiv.org/content/10.64898/2026.02.08.704650v1

Harnessing Microbial Volatile Organic Compounds for Crop Protection: Scientific Discovery, Bridging Ecological Function and On‐Farm Application This opinion article highlights how microbial VOCs can support sustainable crop protection and outlines the ecological, analytical and translational challenges that currently limit their field applic...

Harnessing Microbial Volatile Organic Compounds for Crop Protection: Scientific Discovery, Bridging Ecological Function and On-Farm Application

@microbiotech.bsky.social Opinion by Katharina Belt et al

enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....

The 2026 EMBO course in Computational and Experimental Microbiomics held in @uniofbath.bsky.social has been announced! Come and join us for this course to study host-microbe interactions and co-evolution.
⏰ When: 6-18 July 26
🚨 Registration: 11 May 26
🔗 meetings.embo.org/event/26-mic...

Binning genomes from metagenomes? Try @vijinim.bsky.social new graph visualisation tool to understand where your bins go bad!

metagentools.github.io/graphbin-vis...

Climate change and antimicrobial resistance - Nature Reviews Microbiology In this work, Kalanxhi and Laxminarayan review the evidence supporting the links between climate change and antimicrobial resistance, highlight opportunities for action and identify areas wherein furt...

#AMR #Climatechange #microbes
doi.org/10.1038/s415...

besjournals.onlinelibrary.wiley.com/share/IDDJAE...

Accurate plasmid reconstruction from metagenomics data using assembly–alignment graphs and contrastive learning - Nature Biotechnology PlasMAAG uses cross-sample information to improve plasmid reconstruction from metagenomic samples.

Accurate plasmid reconstruction from metagenomics data using assembly–alignment graphs and contrastive learning www.nature.com/articles/s41... #jcampubs

Ecological Drivers of Nontuberculous Mycobacteria in Aquatic Systems: Biodiversity, Niche Competition, and Pathogen Emergence https://www.biorxiv.org/content/10.64898/2026.02.02.701937v1

Bark microbiota modulate climate-active gas fluxes in Australian forests Recent studies suggest that microbes inhabit tree bark, yet little is known about their identities, functions, and environmental roles. Here we reveal, through gene-centric and genome-resolved metagen...

Bark microbiota modulate climate-active gas fluxes in Australian forests | Science share.google/YXsp5jeKvnXY...

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

Hi everyone!
The talk I had the chance to give with @fnucleosome.bsky.social last October is now out on Youtube!
If you like evolution, 3D genomics, biodiversity and/or fungi, I think you might like it! 🧬🧪🍄
The submission of this paper has never been that close!

www.youtube.com/watch?v=Plez...

A permanent position as a research scientist is opened in our team! We look for a plant physiologist with expertise in plant / microorganism interactions to identify plant susceptibility factors to fungal disease. Please forward!

Forward genetics reveals microsporidian drug targets and recombination-based resistance https://www.biorxiv.org/content/10.64898/2026.01.30.702766v1

The Amt2 Gene is Key for Cryptococcus neoformans Transmigration Across The Blood-Brain Barrier and Closely Linked to Its Capsule Formation https://www.biorxiv.org/content/10.64898/2026.01.30.702728v1

Plasmid mutation rates scale with copy number | PNAS Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...

New paper out in PNAS!!! 🎉

Do more plasmid copies mean faster evolution?

🧵 Dive into the story

www.pnas.org/doi/10.1073/...

Genomic and physiological signatures of adaptation in pathogenic fungi - Nature Communications Emerging fungal pathogens have detrimental impacts on crops, animals, and humans, however little is known about their transition to a pathogenic lifestyle. This study demonstrates that the transition ...

What enables a fungus to invade a mammal host? @marco-guerreiro.bsky.social unravels signatures of translation adaptation among pathogenic and non-pathogenic species of Trichosporonales. See more: www.nature.com/articles/s41...

A Beginner's Guide to Structural Variants in Eco‐Evolutionary Population Genomics Whole-genome sequencing (WGS) has greatly expanded researchers' ability to study structural variants (SVs), that is, the variation in the presence, number, orientation or position of a DNA sequence. ...

Some science for some sanity:

A Beginner's Guide to Structural Variants in Eco-Evolutionary Population Genomics

onlinelibrary.wiley.com/doi/10.1111/...

Confidence-based prediction of antibiotic resistance at the patient level | mBio Improved diagnostic tools are vital for maintaining efficient treatment of antibiotic-resistant bacteria and for reducing antibiotic overconsumption. In our research, we introduce a new deep learning-...

Confidence-based prediction of antibiotic resistance at the patient level | mBio journals.asm.org/doi/10.1128/...

Carbapenem resistant Klebsiella pneumoniae isolates at a tertiary hospital in Cape Town, South Africa, are dominated by specific local clones rather than previously described international lineages Author summary Carbapenem resistant K. pneumoniae (CRKP) have emerged as a cause of hospital and community acquired infections, posing a significant threat to public health, and have hence been listed...

Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...

Current Epidemiology and Infection Characteristics of Non-Aspergillus Mold Infections: A Multicenter Study in Australia and New Zealand We report 421 non-Aspergillus mold infections from Australasia from 2016 to 2023 and observe an increase in cases caused by dematiaceous molds with a decre

Current Epidemiology and Infection Characteristics of Non-Aspergillus Mold Infections: A Multicenter Study in Australia and New Zealand url: academic.oup.com/cid/article-...

Biofilms: from the cradle of life to life support npj Biofilms and Microbiomes - Biofilms: from the cradle of life to life support

We have just published “Biofilms: from the cradle of life to life support” in @natureportfolio.nature.com #Biofilms & #Microbiomes. It highlights how #bioinformatics and #microbiology come together to study biological systems & food-associated biofilms. Stellar multidisciplinary team! rdcu.be/e0esg

Very good outlines. #genomics #ecology #genetics #education journals.asm.org/doi/epub/10....

New research article

Emerging terbinafine-resistant #Trichophyton indotineae between 2018 and 2023: a multinational genomic epidemiology study

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #MycoSky #AMR #OpenAccess #OA

In this review in Fungal Ecology, Håvard Kauserud (@drhyfe.bsky.social) argues that while the ITS region is by far the best DNA (meta)barcoding marker for fungi, we should not use it naively or simplistically doi.org/10.1016/j.fu...

Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations - Nature Biomedical Engineering dSHERLOCK is a nucleic acid platform for the quantification of double-stranded DNA targets using CRISPR/Cas and isothermal amplification and is applied to quantify pathogen C. auris in clinical survei...

Rolando, J.C., Thieme, A., Weckman, N.E. et al. Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations. Nat. Biomed. Eng (2026). doi.org/10.1038/s415...

nph.onlinelibrary.wiley.com/share/EHWXER...

Pathogen-inspired engineering of plant protease enhances late blight resistance | PNAS www.pnas.org/doi/10.1073/...

Fig. 1 Evolution and potential contributions of alternative splicing (AS) along the speciation continuum.

#TansleyInsight: Evolutionary #genetics of alternative splicing in #plants

@peterinnes1.bsky.social, Nolan Kane & @chriscrsmith.bsky.social
👇

📖 nph.onlinelibrary.wiley.com/doi/10.1111/...

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