Krishna Singh Bisht

Dietary nitrate supplementation improves age‐associated neuromuscular outcomes: A step towards healthy ageing Click on the article title to read more.

Our recent journal club @jphysiol.bsky.social summarises the role of nitrate supplementation in improving age-associated neuromuscular outcomes. Congratulations to @jaydeepsharma.bsky.social , Ifrah, & Anamika. Sincere thanks to Prof.Tushar K Maiti & Prof. Sam J Mathew for their guidance.

25.06.2025 20:18 — 👍 3    🔁 1    💬 0    📌 1

A cochlea from a mouse ear after the tissue was transduced with an adeno-associated viral vector expressing green fluorescent protein. CREDIT: Jinan Li

A class of life-saving antibiotics called aminoglycosides can cause irreversible hearing loss by damaging inner ear hair cells. However, using CRISPR to inhibit the autophagy protein GABARAP prevented hearing loss in mice. In PNAS: www.pnas.org/doi/10.1073/...

18.02.2025 19:57 — 👍 11    🔁 3    💬 0    📌 0

Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging
@scienceimmuno.bsky.social
www.science.org/doi/10.1126/...

03.01.2025 19:28 — 👍 11    🔁 5    💬 0    📌 0

3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience.
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)

11.12.2024 17:04 — 👍 118    🔁 44    💬 2    📌 3

5th person confirmed to be cured of HIV Researchers are announcing that a 53-year-old man in Germany has been cured of HIV.

5th person to be cured of HIV

“Today, researchers announced the Dusseldorf patient still has no detectable virus in his body, even after stopping his HIV medication four years ago.”

11.12.2024 07:19 — 👍 42198    🔁 7834    💬 1    📌 1054

Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...

05.12.2024 19:32 — 👍 553    🔁 158    💬 37    📌 40

Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...

Macrophages excite muscle spindles with glutamate to bolster locomotion

www.nature.com/articles/s41...

04.12.2024 17:08 — 👍 25    🔁 3    💬 0    📌 1

24.11.2024 02:35 — 👍 66988    🔁 15043    💬 606    📌 565

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature Neuroscience Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l...

www.nature.com/articles/s41...

21.11.2024 20:04 — 👍 83    🔁 17    💬 0    📌 2