Assoc. Professor Tim J Sargeant

Gabriela Geraldo Benzoni offers this #JournalClub article discussing time-restricted feeding and autophagic flux based on the recent work of Bensalem et al. (2025) ✍️

🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

ICYMI: Autophagy is linked to health span and modified by nutrition.

@timsargeant.bsky.social show a high-protein meal does not alter autophagic flux in human peripheral blood mononuclear cells within 1 hour—challenging the notion that fasting activates autophagy.

buff.ly/aPrgr5F

Check out our new paper! We tested whether a high protein milkshake would suppress #autophagy measured in human blood after 1 hour. Surprisingly we got a negative result, despite clear metabolic responses. @sahmri.bsky.social @jci-insight.bsky.social

insight.jci.org/articles/vie...

I am so bad at this!

Cell type-specific autophagy in human leukocytes: signatures of aging, sex, and nutrient restriction Macroautophagy (referred to here as autophagy) is thought to play a critical role in aging and age-related disease, making it a priority for development of targeted human therapies. We developed a ...

Dr Linh Dang and I penned this commentary on our own article that explores cell-type specific #autophagy in humans. We discuss #aging, sex, nutrient restriction, and the technology we need to better understand this process in people:

www.tandfonline.com/doi/full/10.... @sahmri.bsky.social

Well worth a five minute read - Interventional study showing lifestyle interventions boost #cognition during #aging - the structured intervention group focused on #exercise, #diet advice, and cognitive exercises. Lifestyle is important for #brain aging! www.alzforum.org/news/confere...

New research paper on human #autophagy from our group at @sahmri.bsky.social. Dr Linh Dang analysed autophagic flux with cell type specificity. We show data important for designing clinical trials for human autophagy - cell type matters: faseb.onlinelibrary.wiley.com/doi/10.1096/... #aging

Autophagy across tissues of aging mice Autophagy is a ‘waste-disposal’ pathway that protects against age-related pathology. It is widely accepted that autophagy declines with age, yet the role that sex and diet-related obesity play during ...

Check out our new paper from @sahmri.bsky.social in @plosone.org - measurement of #autophagy using the tf-LC3 system in ageing mice with high fat diet-induced obesity. Tissue-specific responses show us the relationship between autophagy and #ageing is complicated. dx.plos.org/10.1371/jour...

Sunrise from @sahmri.bsky.social with the Adelaide Oval and St Peter's Cathedral

A/Prof @timsargeant.bsky.social is the latest guest to feature on the Community Conversations podcast. 🎙️

A/Prof Sargeant discusses all things autophagy - the latest research, lifestyle interventions, tips for optimising cellular health and more!

Listen 🎧 sahmri.au/CC-Tim-Sarge...

🍽️ Can autophagy increase with age rather than decline?
🤔 What if the story we’ve been told about its decline is missing key details? ⤵️ #aging

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

11th International Symposium on Autophagy

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: www.isa11.org #isa11

Over his career, Emeritus Professor John Hopwood AM set the bar for innovative research.

Now, he and his wife Barbara provide philanthropic support, insisting their donations not be restricted to specific projects to create scientific freedom.

Read 📖 sahmri.au/Cost-of-Rese...

Julien Bensalem et al. observed that intermittent time-restricted eating may increase #autophagic flux in humans 🍽️ 🔬

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial - Communications Medicine Gonzales et al. conducted an open-label phase 1 clinical trial of rapamycin for mild cognitive impairment and dementia due to Alzheimer’s disease. Rapamycin is not detected in cerebrospinal fluid befo...

Crucial new pilot study to investigate whether #rapamycin can be used against dementia causing diseases published yesterday.

www.nature.com/articles/s43...

Intermittent time‐restricted eating may increase autophagic flux in humans: an exploratory analysis Abstract figure legend In this study we used a physiologically relevant measure of autophagic flux in human peripheral blood mononuclear cells (PBMCs) to determine the effect of calorie restriction a....

New study: we measured autophagic flux in human blood and compared intermittent fasting with calorie restriction = the largest human autophagy study to date. Although significant, changes in autophagy were modest. #autophagy #fasting #aging
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Biggest commitment to a 3 second joke I've ever seen

Check out our latest Comment in Nature Cell Biology on #autophagy (the mechanism that cells of your body use to recycle damaged material and slow ageing). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea.

www.nature.com/articles/s41...

New research shows giving antibiotics to newborns can reduce their immune response to vaccines, likely due to changes in gut bacteria. 🦠

This research, led by Prof @davidjlynn.bsky.social, was featured in @nature.com, one of the world's most prestigious journals.

📰 sahmri.au/Newborn-Anti...

Harnessing lysohormesis for healthy ageing - Nature Cell Biology Lysosomal dysfunction is emerging as a common pathogenic mechanism underlying normal ageing and many age-related diseases. Lysohormesis, the triggering of beneficial adaptations by mild lysosomal stre...

Great commentary on 'lysohormesis', for all you longevity fans out there:

"Just as physical exercise stresses the body to build stronger
muscles, a controlled mild stress to lysosomes could boost resilience and improve health outcomes across the lifespan."

www.nature.com/articles/s41...

YouTube video by Dr Matt Kaeberlein The Truth About Biological Age Tests

Matt Kaeberlein giving his opinion on direct to consumer biological ageing tests and the ageing field in general. Definitely worth a watch.

youtu.be/8mlRkXZFvi8?...

Good news on the dementia front - incidence is dropping - "Scientists don’t know what may have had the biggest impact, but recent studies have emphasized the effects of modifiable factors such as exercise, smoking, hearing loss, and hypertension on dementia risk"

www.alzforum.org/news/researc...

a man with a skeleton in the background is wearing a science shirt ALT: a man with a skeleton in the background is wearing a science shirt

#Autophagy and #mTOR papers from past two weeks, enjoy thanks to @biomednews.bsky.social search engine!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

Today, A/Prof @timsargeant.bsky.social accepted an incredibly generous donation following his gripping talk at the Sohn Hearts and Minds Conference last November. 👏

SAHMRI sends our most sincere thanks both to Sohn and the state government for the invaluable opportunity and support.

The specialist team of radiochemists at SAHMRI, known as MITRU, have been featured by 7 NEWS Adelaide. 🎥

Each and every morning, they fire up SA's only cyclotron, producing radiopharmaceuticals that are essential to the state.

More ➡️ sahmri.au/MITRU-Feature

Cheers! I think the 16-24 h number came from mouse work. I, like you, suspect that this won't cut it in humans. We're trying to resolve the caveats at the moment, but we're also working on a protein that is behaving like an autophagy biomarker. That's where I see the future - autophagy biomarkers.

Investigating the Impact of Glycogen-Depleting Exercise Combined with Prolonged Fasting on Autophagy and Cellular Health in Humans: A Randomised Controlled Crossover Trial Importance: Although prolonged fasting has become increasingly popular, the favourable biological adaptations and possible adverse effects in humans have yet to be fully elucidated. Objective: To inve...

There's a huge amount of misinformation about #autophagy out there - " #fast this long for #autophagy!" To understand how to induce autophagy in people, we're working with @LuigiFontanaMD's team to determine if 3 day fasting does increase it in humans: www.mdpi.com/2072-6643/16...

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.

I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Sorry about that