Bruno Rodrigues

I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...

It's #MicroscopyMonday, so let's take a peek into the 🔬
This movie was taken by Shinya Inuoe, who built the polarizing microscope that allowed scientists to see mitotic spindle fibers live for the first time.

Dr. Inuoe premiered his research at MBL.

If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social

Postdoctoral research position in Institut Pasteur

🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏

A new benchmarking study assesses methods for comparing chromatin contact maps in 3D genome research.

www.nature.com/articles/s41...

YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB) In conversation with... Tom Kiselak

🎙️ASBMB's new series features interviews with biological and life sciences professionals about their careers!
ow.ly/268250UYcmx
🎧Check out episode 1: A conversation w/Tom Kiselak (Thermo Fisher Scientific), who holds a #PhD in analytical chemistry & works as a patent attorney: youtu.be/enBtSSTQT9A.

Government isn't a business. The goal isn't to save money. Success isn't measured by budget surplus.

The goal is to spend money, investing in society. Every dollar spent on education, healthcare, and science is an investment in our collective wellbeing.

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇

In summary, we found a dynamical interplay between O-GlcNAcylation and serine 40 phosphorylation of tyrosine hydroxylase (pSer40), where decreasing O-GlcNAcylation leads to an increase in TH pSer40 and L-DOPA levels. Our findings highlight a potential link between diet and neurological functions.

O-GlcNAcylation regulates tyrosine hydroxylase serine 40 phosphorylation and L-DOPA levels | American Journal of Physiology-Cell Physiology O-GlcNAcylation is a post-translational modification characterized by the covalent attachment of a single moiety of GlcNAc on serine/threonine residues in proteins. Tyrosine hydroxylase (TH), the rate...

🚨New paper alert!🚨I'm excited to share the key findings of our latest research. It focuses on a fascinating molecular connection between sugar metabolism and neurotransmitter synthesis, by revealing how O-GlcNAcylation regulates tyrosine hydroxylase. journals.physiology.org/doi/abs/10.1...

One More Time: Why Diversity Leads To Better Team Performance Discussions on diversity in the workplace can be heated and contentious. But the data still shows more diverse teams outperform their less diverse peers. Here's how.

www.forbes.com/sites/roncar...

O-GlcNAcylation in health and disease July 10–13, 2025 | Durham, N.C.

The ASBMB "O-GlcNAc 🟦 in Health and Disease" conference is coming to Duke University, July 11-13, 2025! Thrilled to co-chair with Mike Boyce 🙌

Confirmed speakers in comments👇

Can’t wait to see you there! 🙌

asbmb.org/meetings-eve...

#glycotime #ASBMB

The geometric basis of epithelial convergent extension.
https://elifesciences.org/articles/95521?utm_source=bluesky&utm_medium=social&utm_campaign=organic

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!

@ijmonod.bsky.social @cnrs.bsky.social

The Institut Pasteur is recruiting group leaders!
Pasteur is an absolute incredible environment to start your lab. Surrounded by so many great scientists, in the beautiful city of Paris.
Come eat 🥐 and conduct awesome science.
Contact me if you want info !

research.pasteur.fr/en/call/call...

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social!
tinyurl.com/setd2

The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging.

www.nature.com/articles/nbt...

The curious case of the comb jelly Joan Soto-Angel and Pawel Burkhardt describe a comb jelly with the ability to reverse its development to an earlier stage of life.

The curious case of the comb jelly | Science Sessions | PNAS www.pnas.org/post/podcast...

Listen to our podcast where we describe a #ctenophore with the ability to reverse its development to an earlier stage of life.

@joanjsoto.bsky.social @msarscentre.bsky.social @pnas.org #rejuvenation

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

Liver metabolizes high fructose corn syrup to fructose, which leads to increase production of LPC lipids that promote tumor growth.

#Glycotime

www.nature.com/articles/s41...

Fruit fly female’s seminal receptacle with GFP tagged sperm swimming

A vampire squid, a small deep-sea cephalopod, floats gracefully in dark ocean waters. Its reddish-brown body is illuminated, showcasing its webbed arms connected by a thin membrane resembling a cape. The creature's glowing blue eyes and soft, gelatinous texture are visible, emphasizing its otherworldly appearance.

🦑 The vampire squid (Vampyroteuthis infernalis) isn’t a true squid—it’s a living fossil combining squid and octopus traits! It thrives in the oxygen-depleted "midnight zone." #MolluscMonday

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...

Continuing to go through my trove of cool videos... here is a classic from my work with Philipp Keller's team at @hhmijanelia.bsky.social
A developing fly embryo imaged with a SiMView #lightsheet microscope augmented with our Autopilot self-alignment system.

www.nature.com/articles/nbt...
🧪🔬🪰💻

Check out this new work from Rhiju Das and coworkers @stanfordmedicine.bsky.social, large ornate RNAs form homooligomeric stable complexes, not so different from proteins after all

How cool is that! Thank you to @demishassabis.bsky.social and John Jumper for highlighting our #AlphaFold use to gain molecular insights into the mechanism of fertilization in interviews and even your #NobelLecture! Interested in reading more? Check out our paper! www.cell.com/cell/fulltex...

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

www.nature.com/articles/s41...

Time lapse movie of regenerating crustacean leg Video made by Cagri Cevrim. (hpa = hours post amputation)

Can we observe how the injured leg of an animal is regenerated? We have figured out how to do this in the crustacean Parhyale. Over the course of a week, we can record the entire process of regeneration at cell-by-cell resolution. 1/3
vimeo.com/802413847

The good idea comes when one person feels comfortable enough to say something that might make them look stupid and their friend is open enough to recognize its potential.

Highlighting our recent paper on how we think doublecortin (green) contributes to growth cone biomechanics in developing neurons for #FluorescenceFriday

www.cell.com/current-biol...