Natàlia de Martín Garrido

Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...

Congratulations!!! Great effort everyone!!

Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

New paper out now in Science! Check it out!
www.science.org/doi/10.1126/...

Great effort from everyone!

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants - Nature Communications Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recog...

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone!
www.nature.com/articles/s41...

Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out:
www.sciencedirect.com/science/arti...

🎉👏 ICR's Dr. Natàlia de Martín Garrido @natalia-mg.bsky.social, a postdoc fellow in Dr. Basil Greber's lab @bjgreber.bsky.social was awarded the 'Short Talk Award' for her research on DNA repair at the “Machines acting on DNA and RNA, a molecular mechanistic perspective” conference held in Madrid.

Thanks for your kind words!

Very grateful for receiving a Short Talk Award at #CFM_MolMech

Thanks to the organisers for putting together such an amazing conference! @oscarllorca.bsky.social @rfleiro.bsky.social @nogaleslab.bsky.social @cniostopcancer.bsky.social

The presenter standing at a podium, holding a laser pointer towards the screen.

Delighted to hear that post-doc @natalia-mg.bsky.social has received the Short Talk Award for her #cryoEM studies of DNA repair at the conference on "Machines Acting on DNA and RNA, a molecular mechanistic perspective" at CNIO Madrid. Congratulations, Natàlia!
Photo courtesy of @amunts.bsky.social.

TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network CDK7 kinase activity is found to control RNAPII transcription through a cohort of TFs that drive cell cycle and proliferation.

For our latest paper, we worked with SYROS Pharmaceuticals, the groups of Dylan Taatjes and Robin Dowell at CU Boulder, and @abhaykot.bsky.social. Junjie Feng in my lab determined the #cryoEM structure of the CDK7 inhibitor SY5609 bound to its target...
www.science.org/doi/10.1126/...

Illa demana «ambició i lideratge de la recerca catalana» en la inauguració del nou microscopi de la UB

#InnovacióUB | 🔬 El president @salvadorilla.bsky.social i la consellera de Recerca i Universitats, Núria Montserrat, inauguren el nou microscopi electrònic d’última generació ubicat als espais que els @ccit.ub.edu tenen al @www.pcb.ub.edu. L’aparell obre la porta a estudis innovadors.

High-throughput discovery and deep characterization of cyclin-CDK docking motifs Cyclin-CDKs are master regulators of cell division. In addition to directly activating the CDK, the cyclin subunit regulates CDK specificity by binding short peptide “docking” motifs in CDK substrates...

New pre-print! To support a CDK-cyclin docking motif discovery and characterisation project led by Norman Davey and colleagues, @natalia-mg.bsky.social in my lab determined the #cryoEM structures of three peptide-bound CDK2-cyclin A complexes. Check it out!
www.biorxiv.org/content/10.1...

Twenty-seven scientists become EMBO Young Investigators – Press releases – EMBO The group leaders join an international network of nearly 800 life scientists and receive financial support

Thrilled to share that I have been selected as one of this year's new EMBO Young Investigators. I look forward to meeting many of the other Young Investigators in the coming years, and I am most grateful to the members of my laboratory at the ICR who made this possible.
www.embo.org/press-releas...