John Parkhill

As illustrated every damn day in this wannabe administration.

This is my new email signature.

Prism | A free, LaTeX-native workspace for scientists Write, edit, and collaborate on scientific documents in LaTeX with Prism—a free workspace integrating GPT-5.2 into research and writing.

Getting a 6mo lead in reading papers pre arxiv : priceless. Hilarious ppl are just taking the motivations for this naively.
openai.com/prism/

These are the chipotle slop bowl of science. -- Me at lunchtime.

De novo design of protein binders targeting the human sweet taste receptor as potential sweet proteins Excessive consumption of dietary sugars is a major contributor to metabolic disorders, driving global interest in finding alternative sweeteners with reduced caloric impact. Natural sweet proteins, su...

Carb free sweetened beef is the telelogical endpoint of American civilization, and that goal is in sight.
arxiv.org/abs/2601.145...

It's 16 years after citizens united. If you want to resist the government what you do is sell US stock, treasuries and buy gold, and foreign stock. (really)

Yeah... and if you open source the firmware, everyone wins :P

That's an M5stack, You can use claude to re-create and flash this firmware if you like it. It's a fun weekend project.

If you've actually managed to avoid holiday sickness by shifting hemispheres with your family this winter or sequestering. I wanna hear from you. HOW DID YOU DO IT.

It's basically impossible that Chat bot Ads will remain passive, because any competitor can do the agentic ads, and they will have a margin that is hundreds of times larger.

It's sade's birthday -- The real valentine's day for those who celebrate.

My dread of holiday flights...

Multiscale guidance of AlphaFold3 with heterogeneous cryo-EM data Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational diversity of dynamic...

This is the way arxiv.org/abs/2506.044...

Mean Flows for One-step Generative Modeling We propose a principled and effective framework for one-step generative modeling. We introduce the notion of average velocity to characterize flow fields, in contrast to instantaneous velocity modeled...

Beautiful. arxiv.org/abs/2505.13447

The problem with healthcare in the US is the lack of a market. Consumers are captive, and there is no price discovery process. Despite this, improved technology continues to arrive because the humans pursuing treatments genuinely care.

... And yet we live in a time where fairly complex quantitative reasoning is free. Some would say a reckoning is due. Anyone reading resumes and using AI these days is probably genuinely worried... I am.

I can't decide how I feel about someone vibecoding what is asked for in the job description. It shows initiative? But probably should have added "oh, don't put vibecode emoji's everywhere" to the system prompt.

When your whole exec team is dumping the stock for the last year, this is implied.

Using an algorithmic approach to shape human decision-making through attraction to patterns - Nature Communications Here, using data from a competition between academic teams to influence decision-making, the authors show that people, intending to maximize their profit, prefer options delivering rewards in a discov...

The persistence of docking in drug design has been explained. :P www.nature.com/articles/s41...

RFK Jr. reports up to $1.2M in credit card debt, $30M net worth From law firm payouts to endorsements and book deals, nominee for HHS secretary Robert F. Kennedy Jr. raked in at least $12 million in the past two years.

abcnews.go.com/Politics/rfk...

I will fund a study examining either: author preference for outcomes of an LLM based review process over human cartel, or publication impact in an LLM review process vs. human cartel.

gemini is pretty good at making manim animations with a little help, but boy without UV, manim would be impossible to install.

Yes. this type of thing happens constantly in drug discovery, the cereblon binding etc. but that's precisely why models cannot _replace_ experiments. They are based on observations which are themselves often contradictory, or impossible to explain without entire new domains of knowledge.

If you think we can avoid Thalidomide like outcomes without animal models today, you're an idiot. If you think you're merely marketing, you should appreciate that idiots will listen to you, and the consequences will be real. I will bet anyone 1000$ if this happens it ends poorly.

The transition between "wins nobel prize" and "says vitamin C cures mortality" or "HIV doesn't cause AIDS" or "lobotomies for everyone" or "eugenics is cool" - or "disease is over because I interpolated crystal structures" is crazy short. (all utterances of nobel prize winners)

A virtual cell is like trying to emulate a computer with only the rom, no instruction set, and 20 types of registers you don't even know exist and have no hope to simulate because their physics is chaotic and nonlinear.

Only someone who can't think at 2nd order would ever take virtual cell models seriously without many unrelated breakthroughs. There are obvious, indisputable reasons they are stupid, and no one needs them more than me.

If your field is getting more "perspectives" papers or "position" papers, you're going to get feudalism and dreck. I'd hop :)

"give it to god"-- god of course being the transformer.