Mustafa Khasraw

A HER3-targeting antibody–drug conjugate for leptomeningeal metastasis Nature Medicine - The phase 2 TUXEDO-3 trial identifies the HER3-targeting antibody–drug conjugate patritumab deruxtecan as a promising new therapeutic option for patients with leptomeningeal...

We need to do more to find effective treatments for leptomeningeal metastasis from solid tumors but this commentary from our team shows we are making some progress as a field!
@dukemets.bsky.social
@dukecancer.bsky.social
rdcu.be/eySK8

Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional.
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...

Rescuing dendritic cell interstitial motility sustains antitumour immunity - Nature Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration'
#TumorImmunology

This image of a paediatric brain shows collagen (in green), which is a key part of the ECM, with healthy brain (in pink and purple). Researchers hope that targeting components like this that surround a tumour could open new pathways for immunotherapies to better reach and attack cancers.

A study has found a promising new way to attack high-grade gliomas (HGG), by targeting the cells surrounding a tumour.

The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day
and Dr Ryan Cross are now published in Nature’s npj Precision Oncology.

www.nature.com/articles/s41...

Will the Senate Save NIH? Rescuing biomedical research is every bit as important as saving Medicaid.

It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.

prospect.org/politics/202...

This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...

Delighted to be back in Melbourne to speak at the BCC symposium, listen to exciting scientific presentations and to be with friends @wehi-research.bsky.social @saskiafreytag.bsky.social

🧪

05.02.2025 MEDIA ADVISORY: Senate HELP Committee to Hold Hearing with Secretary Kennedy on HHS Budget WASHINGTON – On Wednesday, May 14, the Senate Health, Education, Labor, and Pensions (HELP) Committee will hold a hearing with U.S. Department of Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. to discuss President Trump's proposed HHS budget for fiscal year 2026. This is the first time in at least two decades that the HHS Secretary is testifying on a presidential budget before the HELP Committee. Agenda: Hearing on Fiscal Year 2026 Department of Health and Human Services Budget; Date: Wednesday, May 14, 2025 Time: 1:00 PM ET/ 12:00 PM CT Location: 430 Dirksen Senate Office Building Witnesses: Robert F. Kennedy Jr., Secretary, Department of Health and Human Services

1/3
PLEASE READ, LIKE, REPOST this "1/3" post

There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)

Can an LLM system become conscious? This question has generated significant debate and too much hype. Here's a paper from @cp-trendsneuro.bsky.social on what neuroscience has to say about that shine-lab.org/wp-content/u...

JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models www.jci.org/articles/vie...

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion

www.biorxiv.org/content/10.1...

Integrated Proteogenomic Characterization of Glioblastoma Evolution: Overcoming Barriers to Develop Personalized Treatment Strategies dailynews.ascopubs.org/do/integrate...

Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma - Nature Medicine A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction...

This #science exciting! Collaborate, #clincaltrials, nurses, scientists - my co-lead H Rizos🤩. #immunotherapy 4 #GBM #glioblastoma Handed draft trial design+drugs to @jimwhittle.bsky.social @braincancercentre.bsky.social

@sydneyuni.bsky.social @melanomaau.bsky.social
www.nature.com/articles/s41...

Add me please

Add me please

Add me please

Outstanding lecture by Martin van den Bent, receiving the Victor Levin award! #SNO2024
@martinvandenbent.bsky.social
@neuroonc.bsky.social
@eanoassociation.bsky.social

Congratulations to Mitchel Berger for receiving the Lifetime Achievement Award. #SNO2024 #ScientificMeeting

Immune checkpoint inhibitors for glioblastoma: emerging science, clinical advances, and future directions - Journal of Neuro-Oncology Glioblastoma (GBM), the most common and aggressive primary central nervous system (CNS) tumor in adults, continues to have a dismal prognosis. Across hundreds of clinical trials, few novel approaches ...

link.springer.com/article/10.1...

Great presentations and discussions on serial biopsies and biologically driven designs at the #SNO2024 Biospecimen Workshop @roelverhaak.bsky.social

Love to be adddd

Small group scholar mentorship #SNO2024

Editorial Scholars Training Session at SNO

Neurooncology Starter Pack Join the conversation

go.bsky.app/7f4adow

Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:

My first post on Bluesky to celebrate 2 full days of science on #glioblastoma (No stone left unturned) with great discussions with outstanding friends and scientists and many new ideas. Many thanks to the Mark and Sontag Foundations.

Automated real-world data integration improves cancer outcome prediction - Nature A study generates a clinicogenomics dataset resource, MSK-CHORD, that combines natural language processing-derived clinical annotations with patient medical data from various sources to improve m...

Huge resource of MSK-IMPACT "genomes", what a treasure trove! Automated real-world data integration improves cancer outcome prediction www.nature.com/articles/s41...