Mihovil Joja

⏰ Timing is everything 🦠 as you will appreciate listening in!

🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧

Our August issue is online now www.mucosalimmunology.org/current, featuring microbes that are “living on the edge” from Mahesh Desai www.mucosalimmunology.org/article/S193...

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model Clostridioides difficile infections often occur after antibiotic use, but they have also been linked to proton-pump inhibitor (PPI) therapy. The underlying mechanism – whether infection risk is due...

Ever wondered why proton pump inhibitors raise the risk of C. diff infections? Is it due to pH shifts or direct antibacterial effects on the gut microbiome? We think it’s the pH. 🧪💡 Dive into Julia & Patrick’s new paper for the full story! 📖👇 #Microbiome #PPI
doi.org/10.1080/1949...

Bacteria poison and eat their neighbors Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors

It’s a bacterium-eats-bacterium world…

www.science.org/doi/10.1126/...

To celebrate this (urp 🤢) exciting new journal series, we made a mini game!

Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."

Share your high score with the hashtag #ResearchIntegrity

pagoba.shinyapps.io/publi_guess/

FUN!! 🤮 6/n

Wooow, is this your first attempt at using expired flowcell?

Have you discovered the Night Science Podcast yet?
@nightsciencepod.bsky.social

HiBC: a publicly available collection of bacterial strains isolated from the human gut Nature Communications - Here, the authors present and characterise a collection of human gut bacteria including novel taxa associated with health conditions and a large diversity of plasmids. All...

Very happy that HiBC is out: rdcu.be/ekSCO 🔥 @natcomms.nature.com Excellent team spirit, and, as always, great driving factor by @tcahitch.bsky.social ⭐⭐⭐⭐ We hope that these bacterial isolates from the human gut will facilitate many studies by others... 😀

Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...

Our "Guide to communicating microbiomes in the media", created in collaboration @lindsaybroadbent.bsky.social aims to help navigate the complexities of communicating microbiome research. Click the link in our bio to read and download the guide.

Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.

Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!

#MicroSky #MicrobiomeSky 🦠

www.nature.com/articles/s41...

Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence fact...

My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...

An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

A very helpful read on tackling procrastination @naturebiotech.bsky.social

www.nature.com/articles/s41...

Planning and describing a microbiome data analysis - Nature Microbiology We provide guidance on the planning, execution and description of statistical analyses in microbiome studies.

A must-read for any microbiome researcher 🦠📐and a new addition to our #bestpractices series

Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social

www.nature.com/articles/s41...

IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences

SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.

OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome

@harriswang.bsky.social & co

www.nature.com/articles/s41...

Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...

OUT NOW: Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion

@lucyicm.bsky.social @cassiebakshani.bsky.social

#microsky 🧪

www.nature.com/articles/s41...

Dear mucosal immunologists!

Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.

Register and see you this July in Aachen! 👇🏼

emig2025.de

@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social

Ten species comprise half of the bacteriology literature, leaving most species unstudied https://www.biorxiv.org/content/10.1101/2025.01.04.631297v1

Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut - Nature Microbiology Metagenomic immunoglobulin sequencing (MIg-seq) uncovered patterns of IgA antibody binding of bacterial strains in the healthy human gut microbiome.

OUT NOW: Metagenomic immunoglobulin sequencing (MIg-seq) reveals IgA coating of microbial strains in the healthy human gut

by Justin Sonnenburg, Matt Olm, Sean Spencer & co

#microsky

www.nature.com/articles/s41...

Surgeons showed significantly greater manual dexterity compared with physicians, nurses, and non-clinical staff when assessed using a buzz wire game.

But had the highest rates of swearing
www.bmj.com/content/387/...

MaAsLin 3: Refining and extending generalized multivariable linear models for meta-omic association discovery A key question in microbial community analysis is determining which microbial features are associated with community properties such as environmental or health phenotypes. This statistical task is imp...

We are happy to announce that the MaAslin3 manuscript is now available on @biorxivpreprint! Check it out and feel free to post feedback on our forums!

www.biorxiv.org/content/10.1...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Diversity within species: interpreting strains in microbiomes Nature Reviews Microbiology - Large-scale metagenomic analyses are vastly increasing the rate of discovery of variation within species but they are also leading to scientific and semantic...

Everyone talks about "strains", but what are they? Within the lab, we often come back to the review "Diversity within species: interpreting strains in microbiomes" by Thea Van Rossum (2020) when discussing at which phylogenetic resolution we do see different signals

www.nature.com/artic...