Ae Mäkinen

Thank you soooo much for this. Kudos to the whole team behind this project. 👏👏

23.10.2025 20:09 — 👍 0    🔁 0    💬 0    📌 0

Few days late,but huge thanks to my home institute, TuDMM-UTU, for the finishing grant 😇✨

20.10.2025 19:44 — 👍 0    🔁 0    💬 0    📌 0

Figure 4 - CSF1 and IL34 protein increase throughout development and display distinct spatiotemporal transcriptional expression patterns; panel L. Density maps depicting the spatiotemporal expression patterns of Il34 (top) and Csf1 (bottom) transcripts in RNAscope™ across development. Left to right: P3, P10, P30. Warmer colours indicate greater while cooler colours indicate lower transcript density.

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:

journals.biologists.com/dev/article/...

17.10.2025 12:18 — 👍 9    🔁 4    💬 0    📌 0

Just presented my work. Now I’m off to my cave to finish writing. Yup, PhD is just a few BIG steps closer. Until then, I’ll keep chugging my matcha to keep me awake, and buying plants to distract me from failed experiments. 😆

21.09.2025 13:02 — 👍 0    🔁 0    💬 0    📌 0

Huge thanks to people who support me everyday: to my real friends in this field who always move with pure intentions, to my friends outside the lab, to my second mother, and most especially, to my loving husband and his family who always believe in me. (3/n)

21.09.2025 13:02 — 👍 0    🔁 0    💬 1    📌 0

It’s always my pleasure to share the science I do, and I am beyond grateful for these opportunities. It’s very humbling. The world is full of envy and people who are unhappy to see our successes, but we strive to move forward and to redirect ourselves to better places. (2/n)

21.09.2025 13:02 — 👍 0    🔁 0    💬 1    📌 0

In 2018, I presented my Bachelors thesis at the biggest Microbiology conference in the Philippines and won the best presentation award. In 2021, I also got a presentation award for my Masters thesis in Taiwan. Last week, I presented my PhD work to the European Macrophage and DC Society in UK. (1/n)

21.09.2025 13:02 — 👍 3    🔁 0    💬 2    📌 0

NIH announces end to funding for animal-only studies - Drug Discovery and Development Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.

If NIH shuts down funding of animal-only grants, get ready for a whole lot of grants to include some pointless organoid experiments just to qualify. What a terrible rule!

www.drugdiscoverytrends.com/nih-announce...

10.07.2025 07:43 — 👍 22    🔁 7    💬 5    📌 1

Honeymoon series

📍Italia

06.07.2025 16:46 — 👍 1    🔁 0    💬 0    📌 0

Our first month of marriage and first midsommar as husband and wife in Åland Islands ♥️☀️

23.06.2025 11:06 — 👍 1    🔁 0    💬 0    📌 0

📘 Our #Neuroimmunology & #Neurodegeneration collection covers a broad range of topics including macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...

@keystonesymposia.bsky.social‬

05.06.2025 14:32 — 👍 8    🔁 5    💬 1    📌 0

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloi...

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

05.06.2025 14:45 — 👍 20    🔁 10    💬 0    📌 0

I got married!

Crazy microglia!

Me outside the summer cottage, the day after the wedding

Spine or kidney? Haha

My month so far. In science, or in life… I love everything that’s been happening! ♥️🥰

27.05.2025 04:46 — 👍 1    🔁 0    💬 0    📌 0

Final push in the lab before I prepare for my wedding 🫣🥰🥹👰‍♀️

21.05.2025 13:11 — 👍 1    🔁 0    💬 0    📌 0

Join us for the Spatial Biology Seminar by Lunaphore Technologies and Bio-Techne!
📅 Date: May 28
🕝 Time: 14:30-16
📍 Location: Seminar room BEAR, Biocity B, 5th floor
We’ll kick things off with coffee&pulla, followed by presentations on spatial biology solutions from Ronald Pouyo and colleagues.

20.05.2025 07:33 — 👍 1    🔁 1    💬 0    📌 0

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

19.05.2025 15:14 — 👍 33    🔁 10    💬 0    📌 1

Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.

A study in Science immunology shows the type of dead cell ingested by macrophages governs their functional plasticity. YOU ARE WHAT YOU EAT
www.science.org/doi/10.1126/...

05.05.2025 19:58 — 👍 8    🔁 3    💬 0    📌 0

I’m getting married 🥹

It just feels surreal that after crossing the horizons to search for greener pastures, I ended up in the happiest place on Earth and found the love of my life: my strength in times of darkness, my biggest supporter when I felt like losing some grip. I’m lucky.

23.03.2025 19:17 — 👍 3    🔁 0    💬 0    📌 0

MSc Karolina Losenkova Mingeaud's dissertation examines the broad network of enzymes involved in ATP and adenosine metabolism, improving the understanding of adenosine metabolism within the tumor microenvironment.

🎩 Losenkova Mingeaud defends the dissertation on 7 March.

www.utu.fi/en/news/even...

04.03.2025 13:30 — 👍 10    🔁 3    💬 0    📌 0

Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk
www.nature.com/articles/s41...

27.02.2025 14:56 — 👍 10    🔁 1    💬 0    📌 0

Hi! I’m Ae. I like studying macrophages & microglia. I like being alone in the dark microscope room, playing with flow cytometers, & challenging myself with bioinformatics. I also have many passion outside the lab: I love to cook, take care of plants, sing, & see new places! Nice to meet you here! 🥰

10.02.2025 20:59 — 👍 3    🔁 0    💬 0    📌 0

Microglial plasticity governed by state-specific enhancer landscapes Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging and disease. Whether these microglial subsets ...

PAMs, DAMs, and WAMs: tracking microglia across the development and disease landscape

www.biorxiv.org/content/10.1...

04.02.2025 02:38 — 👍 13    🔁 5    💬 0    📌 0

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...

03.02.2025 16:36 — 👍 6    🔁 3    💬 0    📌 0

Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model Targeting lipid droplet formation within microglia reduces Aβ accumulation in Alzheimer’s disease mouse brains.

Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model | Science Advances www.science.org/doi/10.1126/...

05.02.2025 20:00 — 👍 16    🔁 5    💬 0    📌 0