Prashant Rawat

Brunello, Xirodimas et al. define key elements of a protein quality control system that operates within the nucleus to eliminate stress-induced nucleolus-related inclusions
www.embopress.org/doi/full/10....

Single-cell dynamics of genome-nucleolus interactions captured by nucleolar laser microdissection (NoLMseq) https://www.biorxiv.org/content/10.1101/2024.06.18.599512v1 Gene position in the nuclear space plays an important role in gene regulation. This is exemplified b

Single-cell dynamics of genome-nucleolus interactions captured by nucleolar laser microdissection (NoLMseq) https://www.biorxiv.org/content/10.1101/2024.06.18.599512v1

PXD057813 🚨

DDX18 coordinates nucleolus phase separation and chromatin organization by interacting with NPM1 in the granular component.

🚨 New dataset alert! 🚨

Pre-rRNA spatial distribution and functional organization of the nucleolus https://www.biorxiv.org/content/10.1101/2024.11.02.621631v1 The self-organized nucleolus is where the pre-ribosomal RNA (pre-rRNA) processing and pre-ribosomal

Pre-rRNA spatial distribution and functional organization of the nucleolus https://www.biorxiv.org/content/10.1101/2024.11.02.621631v1

Mapping and engineering RNA-driven architecture of the multiphase nucleolus - Nature Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.

Nature research paper: Mapping and engineering RNA-driven architecture of the multiphase nucleolus

https://go.nature.com/44Tib11

On the day we were awarded an #ERCAdG from the @erc.europa.eu, I want to highlight this non-science paper I wrote with ‪@deefitzgerald.bsky.social‬ on research culture:

wellcomeopenresearch.org/articles/9-341

Why? Because I'm often told we need to chose between excellence and kindness

nucleoli are dynamically reprogrammed in early mammalian development

The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more.

journals.biologists.com/dev/article/...

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...

Very nice work Shivani, Raffaella and team. Congratulations 🎊 to all

Heyyy. Congratulations Alex, Garrett and team @gginell.bsky.social

Super cool work and looking forward to test all my fav IDRs...

Postdocs in Artificial Intelligence Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health

😱📣 BlueSky-ers: WE NEED YOUR HELP!!! 🙏
All of you who ever liked a lecture of mine...
All of you who liked one of the courses I teach in...
All of you I work(ed) with in one way or another...
All of you who see my desperation! 😜
PLEASE re-post! 🙏 careers.humantechnopole.it/o/postdoc-in...

Microscopy Training Grants Supporting microscopy training for early-career researchers in cell biology Apply for a grant of up to £1000 Journal of Cell Science FocalPlane

Are you an #ECR who would like to attend a #microscopy or #bioimageanalysis training course in the next ~6 months but don't have sufficient funding, check to see if you are eligible for our JCS-FocalPlane Training Grant.

Next deadline: 22 November 2024

www.biologists.com/grants/jcs-f...

The peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉
And don’t miss the chromatin haiku!

www.cell.com/molecular-ce...