Max Schmid

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

And it's out!

I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).

This paper describes a new mechanism for the initiation of autophagosome biogenesis.

We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

A graphic with black text reading "New Preprint from Team Harper" centered on a white background, surrounded by a multi-colored border.

A new preprint from CRN Team Harper found that the depletion of ESCRT-III weakens membranes, allowing alpha-synuclein aggregates to spread and cause damage.

Authors: @harperlabhms.bsky.social
@harvardcellbio.bsky.social @pelletfraction.bsky.social

🔗 Check out the full #preprint: shorturl.at/69Ha6

❕Master's thesis opportunity! The Martens lab is offering a Master's project to investigate how Parkinson's disease aggregates impact the human brain 🧠 Don't miss this chance to dive into cutting-edge research ➡️ tinyurl.com/22epxz4r

A new preprint from our lab is out—a fantastic work by Milica Mihailovic and Aleksandra Anisimova in great collaboration with the @plantophagy.bsky.social Lab.

🆕 #preprint by @gekaragoz.bsky.social lab & us on the crosstalk between #UFMylation & #RQC (ribosome-associated quality control) www.biorxiv.org/content/10.1... As always let us know what you think!

🔊Registration OPEN NOW: Ubiquitin & Friends Symposium, 8-9 May 2025, in Vienna, Austria.
Fantastic guest speakers👇PLUS open slots for talks from abstracts. Great opportunity for #ECRs!
🗓️Deadline for abstracts & registrations: 7 April 2025
➡️ www.protein-degradation.org/symposium/
#ubfriends2025

We updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders!
www.biorxiv.org/content/10.1...

PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy Cellular dormancy represents a state of regulated growth arrest essential for diverse biological processes, from reproduction to cancer progression. While mechanisms controlling protein synthesis in d...

The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/... (1/6)🧵

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna!
Registration will open🔜 Keep an eye out for the announcement 👀
✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting!
🔗 www.protein-degradation.org/symposium/

Would love to join as well!

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

Exciting news! ✨ Sascha Martens and his lab are proud to continue the journey with the Aligning Science Across Parkinson’s Initiative (ASAP), as their funding has been extended! Since 2020, this global collaboration has been exploring the crucial link between mitophagy and PD ➡️ tinyurl.com/fzbht8jd

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

Bio Art

NIAID releases alternative to BioRender, all illustrations freely available in public domain
bioart.niaid.nih.gov

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

🚨 Out now! Bernd Bauer and the Martens lab reveal in EMBO Journal how the cargo receptor TAX1BP1 faciliates the switch from cargo collection to autophagosome formation, a process crucial for successful aggrephagy - the cell's way of recycling aggregated proteins ♻️ More ➡️ tinyurl.com/35ev5pvv

Welcome all (new) followers! Besides our work on probes & biosensors I'd like to share what I know about #Rstats and #DataViz. So I composed a book on data visualization with R & ggplot2 (it's work in progress).
Target audience = wet lab scientists.
Link: joachimgoedhart.github.io/DataViz-prot...