Payal chaubey

Phagocytic clearance of targeted cells with a synthetic ligand - Nature Biomedical Engineering A synthetic protein ligand enables the recognition of surface proteins on unwanted cells, targeting them for engulfment and elimination in vivo.

Crunch, a synthetic ProS ligand for MerTK pathway, can be coupled with antibodies (anti-CD20) to facilitate phagocytic clearance of targeted cells in therapy of lupus @natbiomedeng.nature.com
www.nature.com/articles/s41...

Sorry but personally if a miniature horse woke me up from anesthesia by banging out nonsense on a miniature keyboard it would send me into a liminal space between life and death from which I would never return

Exciting news! Our lab's first-ever paper is now live on bioRxiv! Check it out..

#microglia #astrocytes #neuroscience #neuroimmunology

Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!

As per tradition here is a graphical summary of our paper in comic form.

www.science.org/doi/10.1126/...

The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions - Nature Communications The Human Microglia Atlas includes 91,716 brain immune cells covering six neurologic pathologies. It characterizes the signatures of nine populations and describes the expansion of GPNMB-high microgli...

www.nature.com/articles/s41...

Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy Xenon inhalation modulates microglial responses in mice and is a potential therapeutic agent for treating Alzheimer’s disease.

Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation
www.science.org/doi/10.1126/...

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease

This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩

Welcome to the European Microglia Webinar Series! Here you will find the information and link to every webinar, so dont forget to follow us

😍

Microglia glass painting..

Hatching blastocyst!
When you fix the embryos wayyyy later than you wanted to, because you got caught up;) still a beautiful one though 😉☺️

Super excited for this!!!

Call for abstracts and registration for the #gliameeting in #Marseille starts on 10 December! Learn more about the topics, submission process and the available stipends on the #glia2025 website: loom.ly/AJI_q_Y
Submit your abstract by midnight CET on 5 February 2025!

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems Lloyd et al. generated a comprehensive microglia proteome database, identifying over 11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated with protein synthesis, ...

My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...