George Lountos

Covalent chemical probes Communications Chemistry, Published online: 29 August 2025; doi:10.1038/s42004-025-01652-6Communications Chemistry is pleased to introduce a Collection of research works focused on recent developments within the interdisciplinary field of Covalent chemical probes. Here, the Guest Editors highlight key themes and look towards the future of this research field.

Just out: Covalent chemical probes

29.08.2025 17:04 — 👍 0    🔁 1    💬 0    📌 0

How can you find consistent biological 3D structures in heavily contaminated electron microscopy data sets without using any prior knowledge? #CryoEM #SingleParticle #Reconstruction doi.org/10.1107/S205...

18.08.2025 13:10 — 👍 4    🔁 5    💬 0    📌 0

Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen - Scientific Reports Scientific Reports - Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen

Our latest work on the discovery of new inhibitors of tyrosyl-DNA phosphodiesteras 1 (TDP1) is now published in Scientific Reports.

www.nature.com/articles/s41...

22.07.2025 14:42 — 👍 1    🔁 0    💬 0    📌 0

Scientist presenting talk

Scientist presenting talk

Scientist presenting talk

Scientist presenting talk

Great Hot Structures session at #ACA2025!
ACA Etter Student Award winner Sarah Narehood, @biophyskrys.bsky.social, Nikolas Capra, Rachel Kretsch, Debanu Das, Daniel Richman
@acastructuralsci.bsky.social

20.07.2025 16:17 — 👍 10    🔁 4    💬 0    📌 0

Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE We introduce a new approach to probabilistic multi-volume single-particle cryo-EM ab initio 3D reconstruction for simultaneous estimation of the relative particle 3D orientations and partitioning of the particles into groups with distinct structural states.

Cong T. S. Van et al.: Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE #CryoEM #SingleParticle #Reconstruction ... #IUCr https://journals.iucr.org/paper?S2059798325005686

09.07.2025 00:00 — 👍 6    🔁 5    💬 0    📌 2

Activity and structure of human (d)CTP deaminase CDADC1 | PNAS Vertebrates have evolved an understudied protein termed CDADC1 (NYD-SP15) that contains an inactive N-terminal and active C-terminal DCTD-like doma...

Activity and structure of human (d)CTP deaminase CDADC1 | PNAS www.pnas.org/doi/10.1073/...

05.05.2025 19:16 — 👍 0    🔁 0    💬 0    📌 0

Are you new to #CryoEM, or looking for a review of the basics?

You might enjoy our TRPV1 case study! It covers preprocessing, particle curation, refinement, and more! You can also test your skills with the advanced exercises at the end of the study.
guide.cryosparc.com/processing-d...

#CryoSPARC

16.04.2025 10:55 — 👍 16    🔁 9    💬 0    📌 0

Welcome to the participants of the 2025 #CryoEM course at Cold Spring Harbor Lab @cshlaboratory.bsky.social ! It's going to be a great 2 weeks immersed in all aspects of single particle cryoEM methods.

06.03.2025 16:47 — 👍 20    🔁 4    💬 1    📌 0

Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023 Oncogene - Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023

Impact of the PDB on drug approvals
Open access to the PDB facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023.
Read more in Oncogene
www.nature.com/artic...

26.02.2025 17:12 — 👍 5    🔁 2    💬 0    📌 0