Alessandro Costa

Postdoctoral Fellow - Costa Lab Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Unidirectional MCM translocation away from ORC drives origin licensing Nature Communications - When the MCM motor of the replicative helicase becomes loaded onto chromatin, origin DNA is licensed for replication. Here, the authors show why the ATPase function of MCM...

How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA?

Find the answer in our latest article

rdcu.be/d6D8D

Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬

definitely, let's meet up. I will be doing my first cryoFIB experiment but will make time for a chat! It must be 7 years since I last saw you!

Thank you, Dan!

Amazing work, Jon.

Great to see this, Lucas. Congratulations!

Thank you, Alexey!

Could I afford you? is the appropriate question! ;-) BTW, it is only thanks to the work that you and your lab mates did over the years that I could receive this grant!

Thank you, Rob!

www.crick.ac.uk/news-and-rep...

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.

Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!

3 postdoc positions advertised soon.

Well done, Gideon! Very well deserved.

Great work, Alex and colleagues!

Drew, breathtaking!

Thank you, Andrew!

Happy to be of help, Anna! 😀

Thanks Tim! Lucky to work with a great group of people!

Thank you, Francesca!

many thanks DNA Topology lab 😀!

Congratulations Alessandro and team!

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

Thank you, Luke!

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳

Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors!

rdcu.be/d1F7m