CSConn

Happy to have another Summer complete for SUPERS'25! They are a phenomenal group that I'm fortunate to interact with for our 10wk program. Special Congratulations to the Winners of the Stephen W. Tuttle Research Award Orly Perez Frid & Kaitlin Chung & hope to have this program another 5+yrs!

Congratulations! I know many who will be thrilled to see you in the Philly area and the Cancer Metabolism groups here :)

More of this please:
“As biologists, we know that rigid binary definitions of sex and gender are not supported by scientific observations,” the authors wrote. “As people, we know that insistence on these rigid definitions harms and marginalizes many who do not easily fit within them.”

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

www.cell.com/cell/fulltex...

📌 Pin to your calendars!

🧪 Protein synthesis and translational control🧪

⏳Don't miss these deadlines
Abstracts Jun 1

✏️ Register
On-site Jul 23
Virtual Aug 27

🖱️https://buff.ly/hs1wWTS

#ProteinSynthesis ##TranslationalControl #mRNAtranslation

Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...

Pease add me to ISR :)

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Translation dysregulation in cancer as a source for targetable antigens www.sciencedirect.com/science/arti...

🚨New paper!🚨

A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬

Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏

Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

Was so happy how they grouped (also to dapple in a lil tech work to support three projects in the lab) 🧫 🧪 🧤

Oooo pretty new MassSpec data coming in (only slightly hung-up on the 1/78 samples that wasn't perfect lol)

Looking forward to sharing our research @rutgersupress.bsky.social tomorrow @12 Nelson D406

Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...

Ribosome profiling reveals hidden world of small proteins The development of ribosome profiling (Ribo-seq) by Ingolia et al. introduced a powerful new method for monitoring translation genome-wide. Applicatio…

Excited to share our @cp-trendsgenetics.bsky.social Spotlight Article highlighting the development of #ribo-seq by @nickingolia.bsky.social and how it has revolutionized the study of #microproteins!

www.sciencedirect.com/science/arti...

Graphical abstract of the Organelle Profiling paper, showing the workflow: Endogenously tagged organelle library; Native IP proteomics; Data-driven graph clustering; resulting in a subcellular proteome map with more than 7,600 proteins localized across 19 subcellular compartments.

Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

1/3 🧪

Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells Mitosis is a critical phase of the cell cycle and a vulnerable point where cancer cells can be effectively disrupted, leading to cell death and inhibition of tumor growth. However, challenges such as ...

If you had any question that microproteins / micropeptides are the next wave in #cancer 🌊

Well this is the paper that you need to read.

🔎 microproteins
🧬 💻
#RNAsky
#genomics
#bioinformatics

www.biorxiv.org/content/10.1...

Mechanisms of RNA regulation in cancer progression; lots of selective mRNA translation work

A generative framework for enhanced cell-type specificity in rationally designed mRNAs mRNA delivery offers new opportunities for disease treatment by directing cells to produce therapeutic proteins. However, designing highly stable mRNAs with programmable cell type-specificity remains ...

The first preprint of 2025! Together with Matvei, @halfacrocodile.bsky.social, & our amazing team, we are excited to share PARADE: an AI framework for designing mRNA UTRs with enhanced cell-type specificity & stability. www.biorxiv.org/content/10.1...

Aspartate signalling drives lung metastasis via alternative translation - Nature Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

Congratulations to @fendtlab.bsky.social amd @ginevradoglioni.bsky.social
for this massive work

"Aspartate signalling drives lung metastasis via alternative translation"
www.nature.com/articles/s41...

P.S. 'don't look a gift horse in the mouth' or something to that effect 🥂

Praying I have this luck in New Year!!!

Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation Kuwayama and Powers et al. reveal differences in function for two related RNA remodelers. Dbp1 is poor at stimulating translation, but, when expressed instead of Ded1, it prevents cells from halting growth upon heat stress. This depends on a short disordered Ded1 region but not stress granule formation or reduced translation.

Great work from Gloria Brar’s group on the role of paralogous RNA helicases in the heat shock response. Surprising increase in growth at high temperature and impact of a short motif! Also important implications of the role of biomolecular condensation. Awesome www.cell.com/cell-reports...

nice! we have one of these.. but apparently not the adjustable tip spacing one needed (error made 2yrs ago when it was ordered by prev specialist). Happy to hear your group likes it. I'm leaning towards this b/c we already have the tips too ;)

Direct RNA sequencing is featured as one of The Scientist 2024 Top 10 Innovations. Read to find out how the latest direct RNA #nanopore sequencing kit and flow cell has improved accuracy and output, enabling a more complete picture of the landscape of RNA

Read: www.the-scientist.com/2024-top-10-...

LOL do they have a fav adjustable width one? Idk I never liked/wanted the eppendorf ones, but hard without physically using them to know what works best

What is the best distance-adjusting, multi-channel to go from Eppendorf 1.5/2mL tubes to 96-well plate format?

Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...

Applications for our SUPERS 2025 Summer Internship open today! Share with undergraduates you know interested in learning/studying translational medicine from Cancer Bio, Radiobiology & Imaging, to Medical Physics med.upenn.edu/supers/

@themodzlab.bsky.social worlds colliding ;)