Aino-Maija Leppä

Beneficial genetic changes observed in regular blood donors Researchers at the Francis Crick Institute have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells.

Researchers from the Crick, @dkfz.bsky.social and the German Red Cross Blood Donation Centre have found beneficial genetic changes that arise in the blood stem cells of people who regularly donate blood cells.

www.crick.ac.uk/news-and-fea...

11.03.2025 15:37 — 👍 20    🔁 9    💬 2    📌 3

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...

18.02.2025 09:37 — 👍 50    🔁 20    💬 2    📌 3

Characterization of single neurons reprogrammed by pancreatic cancer - Nature Nature - Characterization of single neurons reprogrammed by pancreatic cancer

Today @nature.com on how pancreatic cancer can hijack our nervous system and how denervation may be therapeutic
www.nature.com/articles/s41...

18.02.2025 00:40 — 👍 221    🔁 52    💬 3    📌 2

Overview of the LEMUR steps: (1) subspace alignment, (2) differential expression, (3) DE neighborhoods, (4) pseudobulking.

After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳

www.nature.com/articles/s41...

LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.

Some highlights⬇️

03.01.2025 19:25 — 👍 155    🔁 35    💬 8    📌 3

I'm very thankful to everyone involved in the study! The project would not have been possible without my co-firsts Karen Grimes and Hyobin Jeong and co-lasts Andreas Trumpp, Jan Korbel and Ashley Sanders 🎉 🎊 5/5

25.11.2024 16:31 — 👍 1    🔁 0    💬 0    📌 0

In another patient with paired pre- and post-treatment samples, two distinct subclones persisted post venetoclax-based treatment. Both had subclone-specific mechanisms to further resistance: a shift toward MEP-like cells and NF1 loss. Go and read more about the other cases! 📜 4/5

25.11.2024 16:31 — 👍 2    🔁 1    💬 1    📌 0

For example, in one patient the sublclone driving relapse had a seismic amplification, upregulated DNA damage response and it also engrafted in mice. We could even see cell-to-cell differences in the copy-number states of the seismic amplification! 🌋 3/5

25.11.2024 16:31 — 👍 1    🔁 0    💬 1    📌 0

We integrated single-cell resolution structural variants, nucleosome occupancy, gene expression and surface proteins to study subclonal growth patterns in complex karyotype AML patient samples 🧬 2/5

25.11.2024 16:31 — 👍 1    🔁 0    💬 1    📌 0

Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype - Nature Genetics An integrated single-cell multiomic analysis of complex karyotype acute myeloid leukemia characterizes intratumoral heterogeneity and highlights links to therapeutic sensitivities.

Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet! 🎉 👩🏻‍🔬

They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5

www.nature.com/articles/s41...

25.11.2024 16:31 — 👍 27    🔁 10    💬 3    📌 0