Kateryna Shkarina

Recruitment for the EMBL International PhD Programme is officially open! 🔊

At EMBL, we train young scientists to become skilled and creative future leaders in academia, industry and other sectors. Start your career in the life sciences with us!

🔎 Read more here:
tinyurl.com/4jdt2ra5

Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...

Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to ‬dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...

If you are looking to build your lab, take a listen to these interviews on @lonelypipette.bsky.social!

www.buzzsprout.com/1356877/epis...

Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.

I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.

(whiteboard art from Zhuonan Li)

We know that diet and lifestyle are strong modulators of inflammatory response, but the exact mechanisms are still elusive. Now the study below adds a piece to this puzzle:

Thanks a lot, good to know about your experience with ABclonal!

10 days left to apply! 👇

Does anybody here have a hands-on experience with SinoBiological antibodies, particularly in immunofluorescence/immunohistochemistry and/or WES/JESS?

I looked at those but unfortunately they seem not to do this type of articles anymore

We have an interesting observation (one data figure with several experiments) regarding one of the commonly used tools, which we believe might be important for the #CellDeath community. Which of cell death/immunology journals still publish article types such as "Correspondence", "Brief reports" etc?

As 2025 is drawing to a close, @jem.org would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 tinyurl.com/2wrxk4mk

Resident phagocytes promote non–cell-autonomous fragmentation of apoptotic cells In vivo dynamics show that phagocytes can mechanically drive fragmentation of apoptotic cells, previously thought intrinsic.

Highlight: a super-cool study from Santavanond et al., showing the role of resident phagocytes in non–cell-autonomous fragmentation of apoptotic cells:
www.science.org/doi/10.1126/...

A weekly issue of Biomed news on everything related to #CellDeath, with some additional papers on other aspects of innate immunity and host-pathogen interactions:
biomed.news/bims-cediti/...

The one validated intervention to slow aging and extend healthspan is not for sale.
It's exercise.
sciencedirect.com/science/arti...

🤝 To promote representation and diversity, yEFIS is creating a 🌟 Rising Star 🌟 list of researchers to support speaker selection.

📝 Please nominate rising stars in your network via this form:

🔗https://docs.google.com/forms/d/e/1FAIpQLSe73pDfFGYBi_hKVqNjkFA65tcb5_KRx3LGpirBzmNMR6dyug/viewform

🚨 Join our lab - we are recruiting a PhD student!

Application deadline: 20.12.2025
Starting date: from 1.04.2026

More info and application👇

Please share

@dib-unil.bsky.social @fbm-unil.bsky.social

#immunosky

Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?

Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!

👉 www.molgen.mpg.de/5094682/Fuey...

We are hiring! 🎓🧫 🧬

Fully funded Postdoc position available in #Immunology at the University of Cambridge. Exceptional opportunity to study human tissue resident T cells across space and time in one of the world's top academic institutions. #postdoc #ERC
www.cam.ac.uk/jobs/researc...

Reminder to apply - talk applications accepted continuously, there is no deadline. We will be seeking speakers throughout all of next year, so if you have a story on metabolism in development you're excited to share, here's the perfect place:

The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and assoc...

Finally, a really interesting study describing a new bacterial mechanism to escape intarcellular innate immune defence:

The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation
elifesciences.org/articles/102...

Inhibition of oligomeric BAX by an anti-apoptotic dimer A full-length dimeric form of the anti-apoptotic protein BCL-w can block oligomeric BAX-driven mitochondrial permeabilization and apoptosis, revealing a new layer of cell-death control.

New structural insights into the anti-apoptotic mechanisms:

Inhibition of oligomeric BAX by an anti-apoptotic dimer
www.cell.com/cell/abstrac...

Two interesting new studies on the novel biophysical aspects of Ferroptosis:

Cell size modulates ferroptosis susceptibility
www.biorxiv.org/content/10.1...

Mechanical confinement induces ferroptosis through mitochondrial dysfunction
www.nature.com/articles/s41...

Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis - Nature Communications The cell death effector Gasdermin A is only known to be activated by Streptococcus pyogenes. This work discovers a mechanism for its activation by Staphylococcus aureus, and shows a conserved role in ...

Some highlights: two studies on GSDMA activation and pore formation:

Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis
www.nature.com/articles/s41...

Dynamic S-acylation of GSDMA regulates pyroptosis:
www.biorxiv.org/content/10.1...

A traditional weekly issue of BioMedNews on everything #CellDeath -related:
biomed.news/bims-cediti/...

Your periodic reminder that science is not done by a few selected "stars scientists". Science is done by hundred of thousands. Siloed money mean a few flashy discoveries and a lot of waste. Want to change things? Make funding accessible and stop funding calls with less than 2% success rate.

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

Ferroptosis induced by inhibition of GPX4 suppressed tumor growth in 2D, but not in 3D or in vivo. Lipids are different

"Lipid Composition Alters Ferroptosis Sensitivity" aacrjournals.org/cancerres/ar...

Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis
www.nature.com/articles/s41...
@natcomms.nature.com @emoryuniversity.bsky.social @larocklab.com