Gary Brennan

ICYMI: Temporal lobe epilepsy affects ~50 million people globally

@brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/odAaTRs

09.08.2025 15:13 — 👍 3    🔁 2    💬 0    📌 0

Delighted to see our recent study published @jci-insight.bsky.social . Here we demonstrate profound disruption of m6A in temporal lobe epilepsy and show that it may regulate seizure susceptibility. Huge thanks to all the authors involved.

@futureneuro.bsky.social
@ucd-sbbs.bsky.social

05.08.2025 06:56 — 👍 3    🔁 2    💬 0    📌 0

Attenuated single neuron and network hyperexcitability following microRNA-134 inhibition in mice with drug-resistant temporal lobe epilepsy The multi-factorial pathophysiology of acquired epilepsies lends itself to a multi-targeting therapeutic approach. MicroRNAs (miRNA) are short noncoding RNAs that individually can negatively regulate ...

🚨 New preprint out! Our latest study shows that blocking miR-134 reduces seizures in mice with established epilepsy. Single-cell and network recordings reveal how this microRNA-targeted therapy could reset brain excitability. Read it here: www.biorxiv.org/content/10.1...

02.07.2025 08:24 — 👍 2    🔁 1    💬 0    📌 0

Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...

29.05.2025 12:35 — 👍 45    🔁 20    💬 6    📌 3

Had a wonderful time at @britishneuro.bsky.social 2025 in Liverpool. Wonderful science, city, people & weather. Also well done @kaushiknarasimhan.bsky.social on giving your 1st poster presentation for the lab. @futureneuro.bsky.social @ucddublin.bsky.social

30.04.2025 15:31 — 👍 4    🔁 2    💬 0    📌 0

⏳ Only 1 week left to nominate a brilliant neuroscientist for the #NSI2025 Awards!

Let’s celebrate excellence in #Neuroscience 🧠✨
🗓 Deadline: April 24
Submit here 👉 neuroscienceireland.com/nsi-2025-awa...

#NSI #NSIAwards #ScienceIreland

17.04.2025 19:17 — 👍 2    🔁 2    💬 0    📌 0

Thanks to @brennan-lab-ucd.bsky.social for hosting me at UCD. It’s been a fabulous visit to Dublin to chat science and soak up the Irish sun.

02.04.2025 13:44 — 👍 2    🔁 1    💬 1    📌 0

Thanks for visiting and the excellent talk!!

03.04.2025 15:24 — 👍 0    🔁 0    💬 0    📌 0

Very proud of the lab who put together a bake sale for Epilepsy awareness Day yesterday. Together they raised over €1000 for @epilepsyireland.bsky.social

27.03.2025 10:54 — 👍 4    🔁 1    💬 1    📌 0

Thanks Cathy!

17.01.2025 13:07 — 👍 1    🔁 0    💬 0    📌 0

I had a wonderful day at the Centre for Discovery Brain Sciences in Edinburgh presenting some of our recent data and learning lots from the wonderful faculty and staff there. Thanks for having me @pdaphd.bsky.social and looking forward to your visit to Dublin soon!

16.01.2025 23:14 — 👍 4    🔁 0    💬 1    📌 0