Koichi Sasaki

IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy Cytokines optimize and fine-tune effector T cell responses. Here, Jiang et al. utilize IL-9, with scarce receptor expression in normal tissues, to boost IL-9R engineered T cells for cancer therapy. IL...

IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy: Immunity www.cell.com/immunity/ful...

Could CAR-T cells carrying collagen targeted IL-12 be a safe therapy for #ProstateCancer?

A team including Prostate Cancer UK fellow @Ko1ssk.bsky.social & Jun Ishihara @imperialcollegeldn.bsky.social share new results in @natbiomedeng.nature.com.

Grab a ☕ and read:
doi.org/10.1038/s415...

@natbiomedeng.nature.com had a 🔥🔥 week this week! Why don't we have any followers on this site 😆😭

'Weaponised' CAR T-cell therapy shows promise against solid tumours So far, immune cells that have been engineered to kill cancers, known as CAR T-cells, haven’t worked well against solid cancers - but a study in mice suggests that could soon change

So far, immune cells that have been engineered to kill cancers, known as CAR T-cells, haven’t worked well against solid cancers - but a study in mice suggests that could soon change

Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models - Nature Biomedical Engineering CAR-T cells are engineered to express CBD-IL-12 upon STEAP1 recognition to enhance tumour-specific immune responses in mice.

Glad to see our work on an advanced CAR-T cell therapy for prostate cancer out now @natbiomedeng.nature.com (www.nature.com/articles/s41...). We will continue to work on developing safer and more efficacious immunotherapies!

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s

Humoral determinants of checkpoint immunotherapy Nature - Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.

rdcu.be/exYGZ

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

Protein editing using a coordinated transposition reaction Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...

Protein editing using a coordinated transposition reaction | Science www.science.org/doi/10.1126/...

CAR trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...