Brandon Logeman

how did I only just become aware of Spicy Pepper Pokémon Scovillain, which evolves from Capsakid and has a “spicy rage attack”.

A hypoxia-sensitive medullary nucleus modulates cerebral blood flow via a disynaptic pathway to cortex https://www.biorxiv.org/content/10.64898/2026.02.20.707130v1

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Acute threats modulate hunger circuit dynamics to instruct avoidance behaviour https://www.biorxiv.org/content/10.64898/2026.02.17.706314v1

Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition https://www.biorxiv.org/content/10.64898/2026.02.11.705362v1

A scalable approach to resolving variants of uncertain significance https://www.biorxiv.org/content/10.64898/2026.02.14.705848v1

Genome-wide single-cell perturbation screens with VIPerturb-seq https://www.biorxiv.org/content/10.64898/2026.02.12.705613v1

Genomic insights into substance use and disinhibitory disorders Externalizing spectrum disorders- spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition - frequently co-occur...

Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...

Identification of a neural basis for anorexia nervosa https://www.biorxiv.org/content/10.64898/2026.02.07.704578v1

Sex-specific control of feeding and defensive behaviors by MC3R neurons in the bed nuclei of the stria terminalis https://www.biorxiv.org/content/10.64898/2026.02.08.702109v1

A multi-omics atlas of human hindbrain development https://www.biorxiv.org/content/10.64898/2026.02.08.704646v1

🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)

A modular transcript enrichment strategy for scalable, atlas-aligned, and clonotype-resolved single-cell transcriptomics https://www.biorxiv.org/content/10.64898/2026.02.06.703342v1

dplyr 1.2.0 dplyr 1.2.0 fills in some important gaps in dplyr's API: we've added a new complement to `filter()` focused on dropping rows, and we've expanded the `case_when()` family with three new recoding and re...

dplyr 1.2.0 is out now and we are SO excited!

- `filter_out()` for dropping rows

- `recode_values()`, `replace_values()`, and `replace_when()` that join `case_when()` as a complete family of recoding/replacing tools

These are huge quality of life wins for #rstats!

tidyverse.org/blog/2026/02...

You can easily switch between magrittr pipe `%>%` and base pipe `|>` in the RStudio settings 🧰

#rstats #dataviz #phd

Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain https://www.biorxiv.org/content/10.64898/2026.02.02.703166v1

A projection atlas of excitatory and inhibitory inputs to the preBötzinger Complex: substrates for multimodal breathing control https://www.biorxiv.org/content/10.64898/2026.02.02.703188v1

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...

A Single-Cell and Spatial 3D Multi-omic Atlas of Developing Human Basal Ganglia and Inhibitory Neurons https://www.biorxiv.org/content/10.64898/2026.01.28.702385v1

Scientific Paper Planner - AI-Powered Research Planning Structure your scientific research with AI-powered guidance. From hypothesis to methodology, plan your research paper with intelligent mentoring.

First week where planyourscience.com had more than 1000 organic users. I know this is nothing by software standards but it is quite something by academic standards. And to everyone using it - tell me what could/should be better. And use it to export a first draft ;)

SqueakPose Studio: An end-to-end platform for pose estimation and real-time edge-AI deployment https://www.biorxiv.org/content/10.64898/2026.01.24.700912v1

Bright calcium-modulated bioluminescent indicators for activity imaging and red photon-assisted synaptic transmission https://www.biorxiv.org/content/10.64898/2026.01.20.700092v1

New preprint on technologies to scale up CRISPR screens.

We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.

We also introduce an approach for cloning lentiviral libraries with billions of elements.

TL;DR: Indirect costs as a percentage of total costs - like the private sector tends to calculate it - for NIH grants is typically around 30-35%.

I'd be interested!

New revolutionary hack about to change our molecular tool-box!

Thanks @ioavlachos.bsky.social for sharing this!

Rapid evolution of a highly efficient RNA polymerase by homologous recombination

www.nature.com/articles/s41...

a man wearing a plaid shirt and a purple hat is saying here we go . ALT: a man wearing a plaid shirt and a purple hat is saying here we go .

Our paper on the Expanded Registry of candidate cis-Regulatory Elements (cCREs) is out 🎉
www.nature.com/articles/s41...

To celebrate, here’s a "meme-torial" walkthrough of the science.

Let’s get started 🧵 1/11

Multiplexed measurements of protein-protein interactions and protein abundance across cellular conditions using Prod&PQ-seq https://www.biorxiv.org/content/10.64898/2026.01.01.697286v1

A free, open-access library of high-quality organism illustrations for science communication We create vector graphics of model organisms and emerging biological research organisms to enhance our publications. We’re sharing these editable graphics under a CC0 license for other scientists to...

A free, open-access library of high-quality organism illustrations for science communication

Just quit Quitting projects in science is hard, but we should be doing a lot more of it.

Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.

open.substack.com/pub/arjunraj...