Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...

Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.

Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...

If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow

"We thank the reviewers for their helpful suggestions"

IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...

Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...

📢 Speaker showcase for our 2nd Meeting #Embryo2026 🧬Vincent Pasque @pasquelab.bsky.social from @kuleuvenuniversity.bsky.social will speak about his work on modelling early human embryogenesis with naïve pluripotent stem cells.
More information👇
www.molgen.mpg.de/embryo2026

We were very happy to welcome this amazing group of early-career researchers as part of the @Falling Walls Science Summit in Berlin! Special thanks to @annaamonaco.bsky.social (Mundlos Lab) and @matthewkraushar.bsky.social for hosting the group and providing an in-depth tour of their labs!

Thrilled to start my Group Leader adventure with these and other great scientists!

Three new research groups joining the MPIMG

We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...

🧬📢 We look forward to welcoming Jacob Hanna from the Weizmann Institute of Science as part of our speaker lineup for the #Embryo2026 meeting!

More information 👇
www.molgen.mpg.de/embryo2026

Redefining cellular reprogramming with advanced genomic technologies Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.

New online! Redefining cellular reprogramming with advanced genomic technologies

🗓️Abstract Deadline Extended
to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org

The IMPRS-BAC call is open until January! Interested in applying to the graduate school? Here are ten tips for a successfull application! ⬇

Check out our projects and apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...

#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de

Redefining cellular reprogramming with advanced genomic technologies Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.

ICYMI: New online! Redefining cellular reprogramming with advanced genomic technologies

SharePic for the contribution of Eileen Furlong from EMBL for the 2nd Meeting on Early embryogenesis & epigenetics organized by the Max Planck Institute for Molecular Genetics in Berlin with support by the Weizmann Institute for Science. The SharePic features the portrait of Eileen and the title of her contritbution "Genome regulation during embryogenesis: Going loopy about enhancer regulation".

📢🧬 Next in the speaker line-up for #Embryo2026 is @eileen-furlong.bsky.social from @embl.org who will present her research on

"Genome regulation during embryogenesis: Going loopy about enhancer regulation"

Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute

Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...

Delighted to share our new study in @natcellbio.nature.com showing that the unique epigenetic landscape of ecDNA can enable the oncogenic enhancer activation of transposable elements! This was a great collaboration with @katerinakraft.bsky.social and @sedonamurphy.bsky.social. tinyurl.com/mwfbu4w4

📢Speaker showcase for our 2nd Meeting #Embryo2026 🧬

@jamesbriscoe.bsky.social from @crick.ac.uk will speak on

The Dynamics of Neural Tube Formation

More information on www.molgen.mpg.de/embryo2026

Structural variants in the 3D genome as drivers of disease Nature Reviews Genetics - Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical...

Our featured article: Structural variants in the 3D genome as drivers of disease - Review by Varun K. A. Sreenivasan, Verónica Yumiceba & Malte Spielmann go.nature.com/4oiPdPQ
Free to read here: rdcu.be/eu0KR

Our November 2025 issue is now live: go.nature.com/4hlXnVx
Topics include: the impact of structural variation on the 3D genome in disease; single-cell DNA sequencing of somatic mutations; the role of transcription compartments in gene regulation; synonymous mutations and their consequences

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...

Hello Boston! The lab is delighted to be at #ASHG25🧬
Check out our talks over the next few days - all unpublished stories.

Kicking things off is @michaelherger.bsky.social presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc

Also 👇

Interested in handling big data and developing efficient algorithms for omics data?
Apply by 07.01.2026 for a PhD position in the lab of Knut Reinert

#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social #gradschool

👉 www.molgen.mpg.de/4775929/Rein...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab

A human-specific regulatory mechanism revealed in a pre-implantation model Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026.
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

awesome new work by my @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues incl @vram142.bsky.social on how chromatin remodelers affect mesoscale chromatin organization www.science.org/doi/10.1126/...

Infotafel mit Schriftzug "Walter Benjamin Programme" und Datumsangaben: 14 October Tuesday 1:30 - 15p.m. CET in English

#ResearchCareers: Just finishing your #PhD and wondering if the DFG’s Walter Benjamin Programme is a #funding option for your next step in academia? Come and find out in our digital info talk on 14 October. No registration, the meeting link will be published here:
➡️ www.dfg.de/en/research-...