A preprint is online where we studied multiple bacterial Arr enzymes that ADP-ribosylate and inactivate rifamycins. Several #PARP inhibitor scaffolds inhibit these enzymes. We also found one that is selective to Arrs.
www.biorxiv.org/content/10.1...
25.02.2025 14:59 — 👍 0 🔁 0 💬 0 📌 0
Chemical biologist passionate about post-translational modifications (PTMs) and a keen interest in drug development. Professor at OHSU leading a team dedicated to unraveling the mysteries of PARPs and ADP-ribosylation.
First gen scientist studying protein & RNA ADP-ribosylation as part of a husband-and-wife team!
Current location: Aachen
Past: Zagreb, Oxford, Amsterdam, Maastricht
Mum of 🧒👧
Our research group at the University of Ottawa specializes in computational enzyme design.
mysite.science.uottawa.ca/rchica/
Professor. Science and social about my lab at Johns Hopkins University working on PARP and RNA biology. Views are my own.
Proud Ballymena Professor. Senior Strategic Advisor at RoRI; Emeritus Prof at Imperial. Former DORA Chair. Husband, father, carer. Also cares about science & equity. Personal a/c. Writes occasionally at http://occamstypewriter.org/scurry/.
Structural biologist and biochemist. CNRS researcher at CBM Orléans @cbm-upr4301.bsky.social. Interested in protein modifications & interactions. Also husband, dad of 2, friend, ☧. Personal website: msuskiewicz.github.io
Structural and molecular immunology and protein biophysics at the University of Notre Dame. T cell receptors, MHC proteins, specificity, and cross-reactivity. Plus drums, odd time signatures, Iron Maiden, and much Rush. Opinions mine alone.
bmblab.nd.edu
Professor and Chair @UCSF/@UCSF_BTS - dynamic structural biology and open science - (he/him) - fraserlab.com
YSBL, Department of Chemistry, University of York, UK. I make, modify and fix stuff. Acta Cryst F main editor with Mark and Cristy. CCP4wg2 chair with Arnaud. Analyse glycan structures with Privateer: https://privateer.york.ac.uk #RealTimeChem [He/Him]
Acta Crystallographica Section D: Structural Biology is a leading structural biology journal published by the IUCr. journals.iucr.org/d
Acta Crystallographica Section F: Structural Biology Communications is a structural biology communications journal published by the IUCr. http://journals.iucr.org/f
Chromatin and cryoEM afficionada. Still a fan of crystallography. Avid Colorado hiker. Will call out ugly nucleosome cartoons. Come for the science, stay for the mountain pictures and snark. Opinions and snark are my own.
RCSB PDB (RCSB.org) promotes a structural view of biology. Funded by NSF, NCI, NIAID, NIGMS, NIH, and DOE
Developing macromolecular structure resources and tools for life science.
- Founding partner of the wwPDB.
- Manage the community-led PDBe-KB resource and the AlphaFold Protein Structure Database, a collaboration with Google DeepMind.
- Part of EMBL-EBI
Instruct offers funded access to structural biology technology and services for researchers in member countries and organisations - utilise high-end machinery, get training, internships, and collaborations!
official Bluesky account (check username👆)
Bugs, feature requests, feedback: support@bsky.app
