Mike Cohen

Looking forward to the biannual #CBP2025 conference @ohsunews.bsky.social starting this week! incredible line up of speakers, including keynotes @mbogyo.bsky.social, @christhechang.bsky.social, and Nancy Carrasco.

www.ohsu.edu/school-of-me...

Congrats!

Excellent study by first author @andriigorelik.bsky.social in @ahellab.bsky.social showing how DTX2 tunes AHR transcription and stability, offering deeper insight into ADP-ribosylation–ubiquitylation crosstalk.

Happy to have made a small contribution during my mini-sabbatical in @ladurner.bsky.social lab!

They demonstrate that a common PARP1 variant (V762) shifts talazoparib from a non-retentive (Type II) to an allosteric, pro-retention (Type I) mode, thereby boosting chromatin trapping and cancer cell killing. The finding makes a strong case for genotype-guided dosing in HRD cancer therapy.

Talazoparib stands out for its strong potency and DNA "trapping" in certain cancers, but why this happens wasn’t clear. A new preprint from first author Jin Cai in the @ladurner.bsky.social lab, together with Ben Black’s team, address this in a new preprint: www.biorxiv.org/content/10.1...

Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!

Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....

My quote of the day

A Video Quote

Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.

(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)

Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows

'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.'
www.nytimes.com/2025/07/10/s...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story

Congrats Jeremy! Well-deserved!

Exciting times in the fields of ADP-ribosylation and ubiquitylation!

This paper, coupled with an exciting new paper from @ahellab.bsky.social and the Van Der Heiden Van Noort groups: www.nature.com/articles/s41...

And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1...

reveal RNF114 as a reader and writer of MARUbylation.

Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.

Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.

Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!

Very cool finding, Matt. Congrats!

💯 👇!

Great seeing both of you!

Today they have crossed a deep red line.

We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.

Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.

Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸

😂. Hopefully Proctor’s gym has been upgraded to include a post-game recovery room, with cold baths and compression gear-haha. Every time I go out and play my body’s reminding me I’m not 25 anymore!

@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!

Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!

Yeah, this was definitely a major milestone for her. Amazing come from behind victory!

Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...