An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function Siglecs are immunomodulatory receptors that regulate immune cell function. A fundamental challenge in studying Siglec-ligand interactions is the low affinity of Siglecs for their ligands. Inspired by ...

Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...

The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions Siglec-10 is a sialic acid-binding immunoglobulin-like lectin implicated in immune regulation, yet its molecular basis for ligand recognition and functional role in immune modulation remain poorly def...

New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social.
www.biorxiv.org/content/10.1...

THE EDMONTON OILERS HAVE MADE IT BACK TO THE STANLEY CUP FINAL 🏆

Voting on ratification of the tentative agreement is open for all NASA members until Thursday, May 8 at noon. Members should check their email for voting information. If you have any questions or issues, please contact the NASA office.

So sorry for your loss!

Scientists should try to repeat more studies, but not those looking for a link between vaccines with autism Funding replicating research is important, but only when allocated well.

Scientists should try to repeat more studies, but not those looking for a link between vaccines with autism

- the replication studies were done and found that there is, in fact, no link between vaccines and autism.

theconversation.com/scientists-s...

Snap election called, as Carney hopes to leverage leadership momentum amid trade war with U.S. Prime Minister Mark Carney has called the 2025 federal election, sending the country into an early campaign, six months ahead of the fixed date.

Snap election called, as Carney hopes to leverage leadership momentum amid trade war with U.S.
www.ctvnews.ca/federal-elec...

#Octopus
They are masters of underwater escape and camouflage.

I had an excellent call with President von der Leyen about the road ahead for Canada-E.U. trade.

Canada and Europe are strong, reliable partners. In a shifting global economy, that matters more than ever. We’re ready to secure new transatlantic business opportunities together.

Mark Carney is elected as the next Liberal party leader and won over 85% of the party votes cast!

‘These tariffs are unjustified’: Smith stands with Trudeau amid U.S. trade war Premiers across the country, including Danielle Smith, are standing united against U.S. President Donald Trump as the country wakes up to a trade war.

‘These tariffs are unjustified’: Smith stands with Trudeau amid U.S. trade war
www.ctvnews.ca/edmonton/art...

Yep, measles is preventable

Connor McDavid scores in OT to give Canada 3-2 win over U.S. in 4 Nations Face-Off final Connor McDavid scored at 8:18 of overtime in the 4 Nations Face-Off championship game to give Canada a 3-2 victory over the United States on Thursday night as the North American rivals turned the last...

From our friends at The Associated Press...
Connor McDavid scores in OT to give Canada 3-2 win over U.S. in 4 Nations Face-Off final
www.ctvnews.ca/sports/artic...

Canada being the best at hockey and the best at everything and you can never defeat us and CANADA! CANADA! CANADA!

Report: CANADA! CANADA! CANADA! CANADA! CANADA! CANADA!

Government of Alberta, You Can't Keep Cutting Class - Graduate Student's Association | University of Alberta Today, we twenty-five students' associations of Alberta urge you to restore operating grant funding for the province's public and nonprofit post-secondary

25 students' associations have sent an open letter to the Alberta government urging it to "restore operating grant funding for the province's public and nonprofit post-secondary institutions (PSIs)."
You can read the full letter at
gsa-ualberta.ca/albertas-pos...
#ableg #abpoli #abpse

We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...

With tariffs signed, Trump warns of ‘pain’ to come for Americans | CNN Politics A day after levying steep new tariffs on Mexico, Canada and China, President Trump acknowledged what economists, members of Congress and even some of his own aides — in their previous lives — have bee...

A day after signing steep new tariffs on Mexico, Canada and China, President Trump acknowledged what economists, members of Congress and even some of his own aides – in their previous lives – have been saying: Americans may find themselves paying the costs.

Live updates: Trump tariffs, executive actions and immigration news | CNN Politics President Donald Trump has announced aggressive new tariffs on Canada, Mexico and China today. Follow for live updates.

Canada and Mexico have announced retaliatory tariffs on US goods following Trump's announcement of steep levies on the 2 countries earlier in the day.

Trump wants to pull U.S. from World Health Organization. Why the UN health body matters | CBC News Germany said Tuesday it will try to dissuade U.S. President Donald Trump from pulling out from the World Health Organization as many global health experts fear the move could substantially weaken glob...

I hope other G7 and G20 countries will step up and fill the massive funding and leadership gap that the U.S. will leave, if it withdraws from @who.int

www.cbc.ca/news/health/...

Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...

Merry Christmas!

Infamous paper that popularized unproven COVID-19 treatment finally retracted Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds

Infamous paper that popularized unproven COVID-19 treatment finally retracted

Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
@cathleenogrady.bsky.social reports.

www.science.org/content/arti...

How cool is this ..the Canadian Pacific holiday train lit up ✨🎄✨🎄✨🎄✨

The SARS-CoV-2 spike protein stays in the brain after a COVID-19 infection.

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