Susanna Ng

NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment Cytotoxicity-associated genes exhibit heterogeneity at the cellular and tissue levels (left). NKG7 gene expression is strongly associated with a cytotoxic gene signature (middle). NKG7 expression is ...

🚨 New Paper in European Journal of Immunology!
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...

Our 3D study of the tumor microenvironment is finally out!

Play around with the data yourself at lung-3d-browser.mdc-berlin.de (Kudos to @danilexn.bsky.social👏 )

Many thanks to Nikolaus Rajewsky lab at @mdc-bimsb.bsky.social and everyone involved, it takes a village to raise a multimodal paper!

Gigantic birth study paints most detailed picture of pregnancy’s toll on body Nature - Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

Gigantic birth study paints most detailed picture of pregnancy’s toll on body

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

www.nature.com/artic...
1/3

“Lab Girl” being censored is baffling. I’ve read this wonderful work; nothing offensive in it whatsoever — unless showing that women can be scientists is no longer “appropriate content” for children?? Everyone go buy a copy in protest. My 2016 review in Nature👇 www.nature.com/articles/532...

Congratulations AG Leppek!!! Awesome news!

NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social

🚨 Job alert 🚨
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇

Happy birthday AG Leppek and congratulations!!!

Natural killer loops: pyruvate in, lactate out - Nature Metabolism Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which regenerates cytosolic NAD+ via ...

Interesting new research from Antoine Marçais’ lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells.

#immunology #NKcells #Immunometabolism

doi.org/10.1038/s422...

See our commentary article here:

www.nature.com/articles/s42...

What a great year for our group! Thanks guys for your constant support, the passion and the hard work you put to bring forward our ideas and projects, and also …. for being amazing Artists&chef pâtissier!

With a photo of the latest ArtAttack, we wish everybody merry Christmas and happy new year!

Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @natureportfolio.bsky.social Huge effort by whole team and collaborators to work this out. www.nature.com/articles/s41...

New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job.

www.nature.com/articles/s41...

#SingleCell #Immunometabolism
#ImmunoSky

Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

‘That’s funny’: creative solutions for time-starved researchers An immunologist and his illustrator friend reveal tips and tricks to help scientists to reach peak performance and creativity.

I love this article about scientific creativity! The cartoons are brilliant
www.nature.com/articles/d41...

Which one are you?
Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics.
–Peter Medawar

🙌

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

First post on Bluesky, let’s share some websites offering many free illustrations for scientific figures 🖼️ 🧪 🌍 :

scidraw.io

bioart.niaid.nih.gov

www.phylopic.org

More well known but very nice though: www.freepik.com

I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.

Made a starter pack for those interested in Innate Lymphoid Cells (#ILC). Please drop me a line when you like to be added! go.bsky.app/BNuUVCx

The 1st rule of day science is to ask for each result, what is the negative control and what is the positive control, because we forget how easy it is to fool ourselves.

Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer Multimodal single-cell RNA sequencing identified a population of CD8+ T cells elevated in tumor tissue enriched for interferon-stimulated genes (ISG). These ISG cells are clonally related to a popula...

I am excited to share our latest paper. We profiled CD8+ TILs from HPV- HNSCC patients using scRNA/TCRseq. In addition, we performed an ex vivo stimulation of cells to capture their transcriptional response. 1/n

onlinelibrary.wiley.com/doi/10.1002/...