Have you ever seen the black box that is the inside of a microscope objective? Today Dr. Stephen Ross of Nikon gave a fascinating lecture on what goes into the design and manufacturing of an objective.
               
            
            
                01.05.2025 18:16 β π 51    π 12    π¬ 1    π 3                      
            
         
            
        
            
            
            
            
                                                
                                                
    
    
    
    
            Happy #microscopymonday from this scan of some primary #astrocytes in culture captured in both brightfield and fluorescence imaging modalities π¬π§ͺπ§ 
               
            
            
                28.04.2025 19:54 β π 16    π 1    π¬ 1    π 0                      
            
         
            
        
            
            
            
            
                                                
                                            Red - NeuN
Cyan - Tyrosine Hydroxylase
Yellow - Hoechst  
                                                
    
    
    
    
            Happy #fluorescencefriday ! 
Decided to switch it up this week with an image of some nigral neurons from some of our labs #parkinsons disease work π¬π§ͺπ§ 
               
            
            
                25.04.2025 05:47 β π 30    π 3    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
                                                
                                                
    
    
    
    
            Itβs that time of week for another #fluorescencefriday ! 
Hopefully you wonβt get tired of looking at #astrocytes because we donβt get tired of imaging them π
π§ͺπ¬π§ 
               
            
            
                18.04.2025 16:04 β π 43    π 4    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
                                                
                                                        
                                                
    
    
    
    
            Big congrats to @megan-hager.bsky.social on her award for innovation in human & animal health presenting the business model of our #microscopy and #imageanalysis core! π¬π§ͺπ§ 
               
            
            
                15.04.2025 21:58 β π 6    π 1    π¬ 1    π 0                      
            
         
            
        
            
            
            
            
                                                
                                            Cyan - GFAP
Red - Hoechst 
                                                
    
    
    
    
            2-for-1 post coming at you for both #worldparkinsonsday and #fluorescencefriday 
Another #astrocyte grown on coverglass reminding everyone of the important role of #glia in #parkinsons 
π§ͺπ¬
               
            
            
                11.04.2025 17:04 β π 39    π 6    π¬ 1    π 0                      
            
         
            
        
            
            
            
            
                                                
                                            Green - GFAP
Magenta - Nuclear counterstain
                                                
    
    
    
    
            Happy #WidefieldWednesday Bluesky!! 
A new hashtag to appreciate all of the wonderful widefield #microscopy work shared here π§ͺπ§ π¬
Today we are sharing this photo of a primary #astrocyte grown on cover glass used in the study of #Parkinsons disease, imaged with a VS200 slide scanning microscope.
               
            
            
                09.04.2025 16:20 β π 25    π 5    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
    
    
            We have considered it! The literature is a bit mixed about the effects of tissue clearing protocols on glial morphology but some of the newer hydrogel-based methods seem promising!
               
            
            
                01.03.2025 16:59 β π 1    π 0    π¬ 1    π 0                      
            
         
            
        
            
            
            
            
            
    
    
    
    
            Nice work π§ͺ
               
            
            
                01.03.2025 02:07 β π 5    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
                            
            
            
            
    
    
    
    
            Happy #fluorescencefriday Bluesky! 
This week, we are sharing a quick video of a 3D render of #alzheimers disease microglia from a Z-stack captured on our VS200 π§ͺπ§ 
We are excited to be connecting with so many research groups world-wide! We continue to be inspired by everyoneβs posts each week!
               
            
            
                28.02.2025 16:18 β π 18    π 3    π¬ 2    π 0                      
            
         
            
        
            
            
            
            
            
    
    
    
    
            βThis week inβ¦β series are really good. There are several with different focuses (e.g., virology, neuroscience, etc.) but are hosted by knowledgeable experts and offer journal-club-esque discussion of novel papers
               
            
            
                28.02.2025 00:53 β π 1    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
                                                
                                            Green - GFAP
Red - ALDH1L1
Blue - DAPI
                                                
    
    
    
    
            Happy #microscopymonday Bluesky ππΌ
Today, we are sharing a high mag image of a primary murine astrocyte captured using an Olympus VS200 slide scanner π§ͺπ§ 
               
            
            
                24.02.2025 18:15 β π 30    π 5    π¬ 2    π 0                      
            
         
            
        
            
            
            
            
                                                
                                            Cyan - TH
Red - Iba1
Green - GFAP
Blue - DAPI
                                                
    
    
    
    
            Happy #fluorescencefriday to the microscopy folks of Bluesky! π§ͺ 
Please enjoy this image hot off the slide scanner piloting our new decon module in a murine #Parkinsons model
               
            
            
                21.02.2025 19:22 β π 29    π 3    π¬ 0    π 0                      
            
         
            
        
    
         
        
            
        
                            
                    
                    
                                    
                            
                    
                    
                                            A support service for Early Career Dementia Researchers Worldwide. Delivered by UCL funded by Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia & the NIHR - https://www.dementiaresearcher.nihr.ac.uk
                                     
                            
                    
                    
                                            Toxicology PhD Student | Graduate Research Assistant | D1 Student-Athlete Alumni
https://www.linkedin.com/in/megan-hager/
                                     
                            
                    
                    
                                            I'm a PhD student in Dr. Ron Tjalkens neurotoxicology and neuroimmune lab!
                                     
                            
                    
                    
                                            @sfn.org journals JNeurosci and eNeuro serve the field by publishing conceptual advances in neuroscience.
https://www.sfn.org/
                                     
                            
                    
                    
                                            We are ONI, home of Aplo Scope, the the revolutionary benchtop super-resolution microscope.
                                     
                            
                    
                    
                                            Neurobiologist @UofSC π¬ Super-resolution #microscopy, synaptic plasticity, cytoskeleton, #neurodegeneration π¦ 
                                     
                            
                    
                    
                                            Science integrity consultant and crowdfunded volunteer, PhD.
Ex-Stanford University. Maddox Prize/Einstein F Award winner
NL/USA/SFO.
#ImageForensics
@MicrobiomDigest on X.
Blog: ScienceIntegrityDigest.com
Support me: https://www.patreon.com/elisabethbik
                                     
                            
                    
                    
                                            feeds: biorxiv, medrxiv, arxiv.q-bio, arxiv.cs, arxiv.math, Research Square
regex: "(neurodegeneration|Alzheimer|Parkinson's|Huntington|amyloid lateral sclerosis|multiple sclerosis|Apoe4)"
All contacts to @willmacnair :)
                                     
                            
                    
                    
                                            The world's largest congress of scientists and researchers working on glial cells. 
Network Glia e. V. | www.networkglia.eu | GLIA 2027 | www.glia-meeting.eu
                                     
                            
                    
                    
                                            The largest nonprofit of scientists & physicians devoted to understanding the brain & nervous system. SfN.org
                                     
                            
                    
                    
                                            The Parkinson's Foundation knows that a research breakthrough can happen at any time & believes in educating our PD community with the latest research updates.
https://www.parkinson.org/advancing-research
                                     
                            
                    
                    
                                            The Parkinsonβs Foundation makes life better for people with Parkinsonβs disease by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinsonβs community.
Parkinson.org
                                     
                            
                    
                    
                                            NYU PostDoc (Liddelow/Chao) and Leon Levy Fellow in Neuroscience studying βastrocyteβ networks! Formerly @ Vanderbilt. Neurodegeneration, visual system, gap junctions, glia, and all things microscopy. MelCooperPhD.com
                                     
                            
                    
                    
                                    
                            
                    
                    
                                            The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and neurodevelopmental disorders. Account run by lab members.
Find us at: youngpearselab.bwh.harvard.edu
                                     
                            
                    
                    
                                            Neuroscientist studying Parkinsonβs disease, viruses in neurodegenerative brain disorders and role of isolation on the brain. Director of a Parkinsonβs Foundation Center of Excellence. Caretaker to one Newfoundland and one Labradoodle. Opinions my own.
                                     
                            
                    
                    
                                            Stanford, UTSW, WashU, Emory, UF & now Indiana Uni SOM Stark Neuroscience. Latina, mother, daughter. Immunity inflammation lysosomes neuroimmuno neurodegen, EIC NPJPARKD. Posts my own.
                                     
                            
                    
                    
                                            Our Mission:
To uncover the mechanisms of glial development and dysfunction and develop breakthrough therapeutic interventions for neurological disease.
                                     
                            
                    
                    
                                            Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer.
www.lukenslab.com