Paula Haynes

Metformin targets mitochondrial complex I to lower blood glucose levels Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.

This is interesting, but likely only the tip of the iceberg because normally inhibiting complex1 is NOT a good thing: it causes electron leak and massive oxidative damage. And it also does not normally feedback on glucose levels. www.science.org/doi/10.1126/...

Aged neurons don’t register energy need Neuronal activity and mitochondrial gene expression become decoupled in aged mice

The link between mitochondrial bioenergetics and brain aging reported in Science. A beautiful study by our neighbours, Huan Ma lab demonstrates that restoring excitation-transcription coupling in mitochondria can improve memory function. This has a potential to reverse age-related cognitive decline.

Chronic social stress induces p16-mediated senescent cell accumulation in mice - Nature Aging Exploring the molecular consequences of exposing mice to social stress, Lyons et al. identify that hippocampal and cortical neurons acquire features of senescence, identifying a mechanism through whic...

Out today @NatureAging!

Life stress can accelerate aging and shorten lifespan, but how remains unclear.

We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress.

Lyons et al. doi.org/10.1038/s435...

As you may know, I have a compulsion-every time I see a cooler or bucket of dry ice- I have to blow on it to see the fog, it makes me feel like I am a dragon breathing fire 😁😁 And I also agree parafilm = magic

Thanks for creating, would love e to be addd!

Cartoon of biosensors for Glucose

Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors
doi.org/10.1016/j.cr...

🙋‍♀️🙋‍♀️

Cool! Would love to be added 😃

Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate

go.bsky.app/KJXNgfZ

Also, any idea how to get access to new PI slack?

Interesting…So why do you think Pffs inhibit Aqp4 complex activity in striatum, but promote it in midbrain? Is there a different in Aqp4 regulation/ capacity in these areas or does it have to do with the Pff load and degree of aggregation? What happens with Pff injection into midbrain directly?

Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specifi...

Science

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
www.science.org/doi/10.1126/...

Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model Cankar et al. report that sleep loss suppresses NREM norepinephrine oscillations in a murine model of Alzheimer’s disease along with a parallel buildup of amyloid-β. Thus, overexpression of amyloid-β ...

Nedergaard lab- impaired increase of infra-slow (30s) norepinepherine-oscillations in APP/PS1 mice after sleep deprivation. Suggests Amyloid-β (or γ-secretase) may impair it's own glymphatic clearance...
www.cell.com/cell-reports...

Super useful tool to import list of people you were following on Twitter to 🦋

Woo hoo! 1K new followers, welcome to 💙🦋!

For science-minded folks, there are some very cool tricks 🚀…

If you use any of these emojis: 👩‍🔬|👩🏻‍🔬|👩🏼‍🔬|👩🏽‍🔬|👩🏾‍🔬|👩🏿‍🔬 your post will index on a Women in STEM feed

If you use 🧪 a Science feed

If you use 🧠 a Neuroscience feed

Go get it 🚀🧪🧠👩‍🔬💙🎊

Donors Rule Everything Around Me When money talks, professors are silenced.

This is a fantastic analysis from student journalists at Penn who have done a better job covering various interests, and the stakes, on our campus than many major media outlets have done all year…

There used to be so many good papers there, but now… so …. Much …. Trash.., and what’s the point if the trash entirely obscures being able to see the last good parts? I feel like the trash stalks me too. Every time I find a way to sort past it, a few days later there is nothing but trash 😞

Title and abstract from the link

We often assume textbook depictions can capture all of the diversity seen in living things--spoiler--they don't. Here's a remarkable example: Mitochondria in neuronal axons lack DNA and don't generate ATP!!! 🧪 1/2
www.biorxiv.org/content/10.1...