Corey Griffith

Check out our article in this issue on the metabolite repair role of CLYBL!

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

Some really nice points outlining the misuse of metabolomics in pathway analysis.

To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite levels increase or decrease. This is not the same as up/down regulation.

doi.org/10.1038/s422...

Thanks for sharing!

Thank you!!

Give it a read! Free access: rdcu.be/eebr8

CLYBL averts vitamin B12 depletion by repairing malyl-CoA - Nature Chemical Biology CLYBL has a role beyond itaconate catabolism to degrade malyl-CoA, a noncanonical metabolite and methylmalonyl-CoA mutase inhibitor that depletes coenzyme B12, implying that malyl-CoA contributes to t...

Non-canonical metabolites are continuously formed in primary metabolism & #MetaboliteRepair enzymes have evolved to eliminate these often toxic byproducts. Out today in @nchembio.bsky.social, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion 🧪

A Bleak Future? Recent layoffs and funding cuts have not only crippled morale among scientists, they’ve also set an alarming precedent for the future of science

I had the opportunity to give my perspective to The Analytical Scientist about recent events. With this article, I hope to give a voice to others who may not have the ability to speak out. #StandUpForScience

theanalyticalscientist.com/business-edu...

Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers:

The HuMet Repository - Watching human metabolism at work

www.sciencedirect.com/science/arti...

All data provided in an interactive repository:

humet.org

The T32 training grant supported the interdisciplinary and multi-department design of the UC Riverside Environmental Toxicology Graduate Program. Funding from it gave me valuable time to focus on research and I am eternally grateful for the impact it has had on my career.

Thank you @jeremymberg.bsky.social for highlighting the special importance of T32s. This allowed me to launch an interdisciplinary chemistry/biology interface (CBI) graduate program at UCB in early 2000s. For the first time, due to this funding, chem PhD students were able to do rotations. 1/n

the rich and powerful want to destroy biomedical science, like they wanted to destroy climate science, and before that tobacco science and before that asbestos science -- because science and universities are an independent source of truth that can reduce the power and money of oligarchs.

Mechanisms of metabolism-coupled protein modifications - Nature Chemical Biology This Perspective highlights how metabolic states regulate diverse protein modifications that affect physiology. In addition, the roles of subcellular localization of metabolic enzymes and the importan...

Neat perspective on the connection between metabolism & PTMs.

Cells spend a lot of effort combating reactive chemistry, but they also take advantage of it. The line between utility and toxicity must depend, at least partially, on metabolite/protein repair enzymes.

www.nature.com/articles/s41...

Why aren’t they taking the fired federal workers who are sharing their heartbreaking stories—the ones that Musk says were being paid to do nothing—and making them famous? The cancer researcher on the verge of a breakthrough? The park ranger in Yosemite who won’t be there to conduct rescues and save lives? The air traffic controller who can speak to the connection between understaffing and recent plane crashes? Is it even safe to fly in Trump’s America? The Democrats should be amplifying these folks—writing op-eds about them, refusing to go on camera without sharing their spotlight, pressuring their IG influencers to raise them up—but instead, we learn their stories from Reddit. As Moira Donegan wrote in The Guardian, “Why are the Democrats so spineless?”

I've noted some of the procedural things Democrats could be doing in Congress, but this point from @edgeofsports.bsky.social's great piece in the Nation deserves emphasis.

This is basic politics, and it's baffling that every Democrat isn't doing it every day.

www.thenation.com/article/poli...

Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠

sciencehomecoming.com

Yes, and this is super-important.

People don’t know what’s happening. Most of the country has no idea that American science — cancer cures — are being shredded. They really don’t know!

The job of all scientists 🧪 in this moment should be to get the word out.

Rhodoquinone carries electrons in the mammalian electron transport chain Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:

www.cell.com/cell/fulltex...

Darby makes this point but I just want to reinforce it: These words are entirely legitimate to discuss science, accurately and correctly. This attack on "DEI" (🙄) is not only an attempt to resegregate science but also an attack on expertise, itself.

Resisting it is a defense of science

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg

Hey Erik! Could you please add me to the Science feed? Thanks for the help! Proof: scholar.google.com/citations?us...

CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by eliminating malyl-CoA https://www.biorxiv.org/content/10.1101/2024.09.25.614871v1 Citrate lyase beta-like protein (CLYBL) is a ubiquitously expressed mammalian enzyme known for its r

CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by eliminating malyl-CoA https://www.biorxiv.org/content/10.1101/2024.09.25.614871v1