Twist Bioscience

Introducing our new (free!) service that connects you with Twist experts for personalized project help. Submit a request, get matched, and connect at your convenience via chat, email, or virtual meeting—whatever works best for you.

Connect with an expert: www.twistbioscience.com/meet-the-exp...

Twist is redefining High-Throughput Screening…
With access to pooled gene-length sequences, you can finally build unique, precisely defined screens that would otherwise be impossible.

🥳 No more compromises between speed and sequence complexity. Get started: www.twistbioscience.com/products/gen...

We are happy to announce the appointment of Trynka Shineman Blake to our board of directors!

Ms. Shineman Blake most recently served as CEO of Vistaprint, and brings nearly three decades of experience across multiple strategic areas.

➡️ investors.twistbioscience.com/news-release...

Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology - Translational Psychiatry Translational Psychiatry - Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology

Read the paper here: www.nature.com/articles/s41...

Hepatitis C Found in Brain Lining Linked to Schizophrenia, Bipolar Disorder - Neuroscience News Researchers have discovered hepatitis C virus (HCV) in the brain lining of individuals with schizophrenia and bipolar disorder, suggesting a possible link between infection and psychiatric symptoms.

Leveraging our Twist Comprehensive Viral Research Panel, a new study discovered hepatitis C virus present in individuals with schizophrenia & bipolar disorder, suggesting a possible link between infection & psychiatric symptoms:

🍦With summer in full swing and blue skies overhead, our Wilsonville Twisters enjoyed a refreshing break with fresh-scooped ice cream!

Sponsored by the Twist sales team as a thank-you to manufacturing for another busy & successful quarter, the event was a sweet way to celebrate

Custom enrichment for RNA sequencing of liquid biopsies | Twist Bioscience Believe in Better: Leading the Way in Target Enrichment

Custom enrichment for RNA sequencing of liquid biopsies: www.twistbioscience.com/resources/we...

Precise RNA targeting with CRISPR–Cas13d - Nature Biotechnology Careful selection of Cas13 variants and delivery methods minimizes collateral RNA degradation.

From Neville Sanjana and team: “Precise RNA targeting with CRISPR–Cas13d.” www.nature.com/articles/s41...

Twist RNA Library Preparation with the Universal Adapter System: www.twistbioscience.com/resources/pr...

Starting with RNA to Find Fusions: www.the-scientist.com/starting-wit...

Trending Applications in RNA Sequencing | Twist Bioscience In this blog, we explore the current state of RNA-seq, giving a brief overview of the technology and the ways in which it is being applied, as well as tools that enable researchers to reap the benefit...

Trending Applications in RNA Sequencing: www.twistbioscience.com/blog/science...

Efficient, exon-aware RNA capture for gene expression and novel fusions: www.twistbioscience.com/resources/te...

Shhhh, don’t tell DNA, but we’re huge fans of RNA too. Happy #RNADay from all of us at Twist! 🥳

We’ve rounded up some of our favorite RNA resources, check them out ⤵️

Unleashing the Power of RNA-seq— Optimizing with Twist Solutions: www.twistbioscience.com/blog/science...

🥳 Happy #NationalInternDay! 🧬
Shoutout to our incredible interns, Skyler Asher, Abinaya Ravi, Adhvaith Ravi, Clayton Lau, Veda Kalwala, and Yash Tomar, for bringing curiosity, energy & bold ideas. We love that you’re part of the team and the next generation shaping the future of biotech!

🎉 We are excited to announce the launch of a humanized transgenic (HuTg) mouse model to expand and complement our offering of antibody discovery services + further streamline monoclonal antibody discovery!

➡️ investors.twistbioscience.com/news-release...

What causes Parkinson's disease? Scientists uncover an unexpected new clue. — National Geographic A recent study linking human pegivirus to Parkinson’s is leading scientists to examine the connection between other viral infections and neurodegenerative diseases.

A recent study linking human pegivirus to Parkinson’s is leading scientists to examine the connection between other viral infections and neurodegenerative diseases.

🧬 Genes, genes, & more genes.
🎙️ Did you know we have 30+ webinars all about genes?

From AI-driven gene design & plant synbio 🌿 to ♻️ & upcycling plastics — discover how scientists are pushing boundaries with Twist Genes: www.twistbioscience.com/resources/we...

🚨 Upcoming Webinar Alert!

Join @twistbioscience.com as Dr. Fong Tian Wong (A*STAR, Singapore) dives into the fascinating world of synthetic biology — where dormant gene clusters in Actinobacteria are activated to unlock novel metabolite production.

#SyntheticBiology #Webinar #EnablingDiscovery

Base Pair Bulletin July news about Twist Bioscience featuring new NGS workflows, exome, DNA, customer papers, gene fragments faster and at 7 cents a base, webinar and more

July highlights are here! This short and sweet summary includes cutting edge customer papers, our latest NGS efforts, tomatoes 🍅 with built in sunscreen, and where in the world you can find us in August..

🎉 We are thrilled to share that our own Patrick Finn has been honored as Executive of the Year by Portland Business Journal.
He is recognized for outstanding leadership & impact in Oregon’s manufacturing community.
Congrats Paddy on this well-deserved honor: www.bizjournals.com/portland/new...

DeepMind’s AlphaGenome Aims to Decode DNA’s ‘Dark Matter’ — Scientific American This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger everything from cancer to rare genetic disorders—and potentially revolutioniz...

This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger everything from cancer to rare genetic disorders—and potentially revolutionizing personalized medicine.

Genetically engineered chestnut tree, grown in Syracuse, moves one step closer to release SUNY ESF's transgenic American chestnut tree could help save the tree from the brink of extinction.

Genetically engineered chestnut tree, grown in Syracuse, moves one step closer to release

Optimized in-solution enrichment of over a million ancient human SNPs - Genome Biology Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with enviro...

🧬 A must read for those working with ancient DNA! From Bastien Llamas and team: “Optimized in-solution enrichment of over a million ancient human SNPs.”

First detection of Sindbis virus in wild birds in Nigeria - Scientific Reports Scientific Reports - First detection of Sindbis virus in wild birds in Nigeria

🦠 The Twist Comprehensive Viral Research Panel was selected to support this important work by Jonas Waldenström and team: “First detection of Sindbis virus in wild birds in Nigeria.”

Simple high-throughput encoding of deep mutational scanning libraries by oligo-based Golden Gate assembly Control over mutational library diversity is an essential consideration when engineering proteins, but is often fraught with trade-offs between diversity, specificity, and affordability. Contemporary ...

📐📏 Simplifying mutagenesis with direct hybridization of oligo pools from William Kelton and team. “Simple high-throughput encoding of deep mutational scanning libraries by oligo-based Golden Gate assembly.” www.biorxiv.org/content/10.1...

Systematic molecular glue drug discovery with a high-throughput effector protein remodeling platform Realising the promise of new medicines that operate through a targeted molecular glue-induced degradation mechanism requires systematic tools that can uncover the relevant principles of neomorphic pro...

🪢 Benedict CS Cross and team have a new preprint: “Systematic molecular glue drug discovery with a high- throughput effector protein remodeling platform.”
www.biorxiv.org/content/10.1...

Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology - Translational Psychiatry Translational Psychiatry - Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology

“Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology”

🧠 New research from Maree J. Webster and team utilizing the Twist Comprehensive Viral Research Panel found Hepatitis C virus in the brain lining of people with schizophrenia and bipolar disorder, suggesting infection may play a role in these psychiatric conditions…

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...

“De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells.”

Happy Friday! We have your weekend reading covered with this curated selection of up to the minute papers featuring work from Twist customers.

1st up: 🤖 Hot off the press from Timothy Jenkins and team advancing immunotherapies with AI…