Bhawik Jain's Avatar

Bhawik Jain

@jainbhawik.bsky.social

Cell and Molecular Biologist, Cricket enthusiast

10 Followers  |  21 Following  |  3 Posts  |  Joined: 07.03.2025  |  1.4953

Latest posts by jainbhawik.bsky.social on Bluesky

@vai.org @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social
#flippase #membrane-transport #neomycin #lipid transport

14.07.2025 19:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Our study explains why yeast cells lacking Neo1 are neomycin sensitive, which targets PI4P when it is exposed on the outer leaflet of the plasma membrane. We show that Neo1 flips PI4P, offering key mechanistic insight into how phosphoinositide membrane asymmetry is maintained. @vuartsci.bsky.social

14.07.2025 19:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
P4-ATPases control phosphoinositide membrane asymmetry and neomycin resistance Nature Cell Biology - Jain et al. report that the Neo1 P4-ATPase flips the lipid PI4P across the Golgi membrane to the cytosolic leaflet, preventing PI4P exposure and thereby conferring neomycin...

Excited to share our latest work published in @natcellbio.nature.com! We identify Neo1 as a novel phosphoinositide flippase that maintains membrane asymmetry and provides resistance to neomycin.@grahamlab-vandy.bsky.social. Check out the article and News & Views here
rdcu.be/eweby
rdcu.be/eweh9

14.07.2025 19:28 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

As April comes to a close, we wanted to share updates for the first quarter of 2025!!

30.04.2025 01:43 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

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