Ye Lab

I’m sorry to say sd is not very sunny this week haha

RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy.

Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)

Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)

Did aha approve the chips?

Deeply honored to receive this year's Tianqiao and Chrissy Chen Young Investigator Award from @sfn.org Grateful to all lab members and my mentors.

Come be my newest colleague! Scripps neuro is an energetic and supportive department, and uniquely benefits from proximity to our intimidatingly awesome chem and drug discovery programs. Happy to chat about my experiences here so far!

Scripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense”

The NIH has awarded a $14.2M Director’s Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.

A parabrachial hub for need-state control of enduring pain - Nature Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain.

A brief rundown...

www.nature.com/articles/s41...

Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond.

Free registration link: www.eventbrite.com/e/dorris-neu...

What a small world!!! We left the island the next morning.

We were likely both at this place last night!

Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others!

Welcome back!

The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.

“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”

Read the article here. No subscription required:

www.nytimes.com/2025/06/03/u...

Congrats to Assist. Prof. Chen Ran (@chenran.bsky.social), one of just 15 selected as a 2025 Searle Scholar! 🌟

His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN

SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025 Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or …

Congratulations to @chenran.bsky.social on being named a Searle Scholar!

searlescholars.org/2025/04/14/s...

Interoceptive processing in the nucleus of the solitary tract The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...

Great collaboration with @liye-tsri.bsky.social @dlipomi.bsky.social, and Jonathan Long labs and led by Yu Wang and Yunxiao Zhang 2/2