Nadejda Bozadjieva Kramer

Great session examining the role of glucagon and glucagon signaling in metabolic disease! #ENDO2025

14.07.2025 00:19 — 👍 3    🔁 1    💬 0    📌 0

Bypass and Beyond: Redefining Roles and Mechanisms of Obesity Treatment at ENDO 2025 - Endocrine News Endocrine News talks with the chair and presenters of “Bariatric Surgery and Emerging Medications: Redefining Roles and Mechanisms,”an ENDO 2025 session that analyzes a variety of factors that are imp...

Excited to be part of ENDO 2025 endocrinenews.endocrine.org/bypass-and-b...

18.06.2025 22:56 — 👍 1    🔁 0    💬 0    📌 0

Bariatric Surgery is beneficial for treatment of patients with obesity over a lifetime #obesity #bariatricsurgery #medsky #surgsky #Skymed #skysurg GLP-1 #wls metabolic bariatric surgery

05.01.2025 20:02 — 👍 16    🔁 3    💬 1    📌 0

UofMichigan at @keystonesymposia.bsky.social #MASH and #obesity

27.02.2025 04:43 — 👍 4    🔁 1    💬 0    📌 0

The evolution of steatosis and fibrosis in mice on a MASH-inducing diet and the effects of housing temperature | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society Background & Aims: Obesity induction in mice requires high-fat diet exposure. While hepatic steatosis develops, progression to inflammation and fibrosis, as in humans, requires prolonged exposure and additional dietary factors. Immunosuppression at room temperature may slow this progression. We evaluated thermoneutrality's effect on MASH development using a fibrosis-inducing MASH (GAN) diet. Methods: Mice were fed either MASH or chow diet and housed at room temperature or thermoneutrality. MASH diet groups were sacrificed monthly from 4 to 7 months. Serum markers of hepatic function were analyzed, and liver histology assessed steatosis, inflammation, ballooning (NAS score), and fibrosis via Picrosirius Red staining. Results: MASH diet increased body weight, liver-to-body mass ratio, and hepatic fat, with no difference between housing conditions. Housing temperature had minimal effects on MASH. Serum markers and hepatic fibrosis were similar across groups. NAS score was lower at 4 months in thermoneutral MASH mice but not by 7 months. Conclusion: Thermoneutrality did not significantly impact MASH development. These findings, alongside existing literature, suggest thermoneutral housing does not consistently enhance MASH progression in GAN MASH-fed mice.

And one more paper! Dr. Neil Blok shows the evolution of steatosis and fibrosis in mice on a MASH-inducing diet and the effects (or lack of) of housing temperature @seeleyrj.bsky.social journals.physiology.org/doi/abs/10.1...

26.02.2025 20:18 — 👍 2    🔁 1    💬 0    📌 0

Intraduodenal Administration of Reg3g Improves Gut Barrier Function and Mitigates Hepatic Steatosis in Mice | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Socie... Regenerating islet-derived protein 3g (Reg3g), a gut peptide has been implicated in host defense and various physiological functions including metabolic regulation. Emerging evidence has demonstrated ...

Our new paper shows that intraduodenal administration of Reg3g improves gut barrier function and mitigates hepatic steatosis in mice @seeleyrj.bsky.social journals.physiology.org/doi/abs/10.1...

26.02.2025 20:17 — 👍 3    🔁 1    💬 0    📌 0