Robert Screaton

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔

In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...

front 3 rows half empty for an elimination game, guess they know who's going to win 📝

A genetic map of human metabolism across the allele frequency spectrum - Nature Genetics Genome-wide association analyses of 249 circulating small molecules and lipoprotein characteristics across the allele frequency spectrum in UK Biobank advance understanding of genes and pathways regulating human metabolism.

A genetic map of human metabolism across the allele frequency spectrum

www.nature.com/articles/s41...

PP2A-B55α activates TFEB upon mitochondrial damage to support Parkin-dependent mitophagy.

In this week's mitophagy news 🪫🗑️

biomed.news/bims-tofagi/...

⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

Thanks to @biomednews.bsky.social

#typeresilient | Diabetes Canada Living with diabetes means no breaks and still conquering those late-night lows. No matter what time of day, we're here with support you can trust along the way. Together, we are #TypeResilient. Lear...

www.linkedin.com/posts/diabet...

🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!

On Truth and Reconciliation Day, we wear orange to honour survivors of residential schools and remember those who we lost. Reconciliation is ongoing work, and we remain committed to listening, learning, and walking together with respect.
#EveryChildMatters #OrangeShirtDay #TruthAndReconciliation

Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...

Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta Mitochondria adapt their structure through fusion and fission, yet how their morphology and cristae architecture alter as cells differentiate remains unclear. The human placenta is an ideal model for ...

www.biorxiv.org/content/10.1...

HHMI adopts Plan U journals.plos.org/plosbiology/...

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

Three word wine review: a bit soapy

Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes.
Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity The brain is a metabolically demanding organ as it orchestrates and stabilizes neuronal network activity through plasticity. This mechanism imposes enormous and prolonged energetic demands at synapses...

Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
www.biorxiv.org/content/10.1...

Check on your Yankee fan friends

Friendly reminder that no one likes the Yankees.

goodnight, tommy pham #bluejays

It was great fun to write this review with friends and colleagues Melkam Kebede, Belinda Yau, @jinghughes.bsky.social and Julien Ghislain

Future Directions and Clinical Trial Considerations for Novel Islet β-Cell Replacement Therapies for Type 1 Diabetes Type 1 diabetes results from the immune-mediated loss of insulin-producing pancreatic islet β-cells, rendering those affected dependent on exogenous insuli

A road map for using stem cell-derived islet cells to treat (cure?) T1D diabetesjournals.org/diabetes/art...

How thoughtful experimental design can empower biologists in the omics era - Nature Communications Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...

"Why biological replication is more important than sequencing depth" www.nature.com/articles/s41...

Are you living with T1D*? Are you parenting a child with T1D? Do you have a family member, partner, or friend with T1D? *or LADA/MODY/type 3c diabetes You are not alone … find your type 1 diabetes community! Join CommuniT1D.ca, a free Canadian program of monthly online meetings. talk to others with shared experience share your story share what you know get & give support learn improve your wellbeing make new friends find diabuddies (buddies with diabetes) get connected build community The program will match you with a small group of others (about 4-6 people total) according to your interests and what matters to you. JOIN US at communit1d.ca A drawing of six people with arms around each other, several sensors visible on their arms CommuniT1D.ca is funded by Breakthrough T1D Canada (formerly known as JDRF Canada) and the Canadian Institutes of Health Research. The program was designed and is run by people living with T1D or LADA, parents of children with T1D, scientists, doctors, and other experts. Research ethics approval: CIUSSS-CER-S 2024-2887

If you are an adult with #t1d in Canada please check out CommuniT1D.ca
It is an online peer support program for people with T1D and I'm also really excited as a health researcher who lives with type 1 diabetes to be involved in its creation and evaluation.
Also please share with all your DiaBuddies!

It's been a while - what's new with Coldplay?

www.instagram.com/reel/DL8VGB_...

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...

The role of GLP1 receptor agonists in adult-onset type 1 diabetes mellitus Nature Reviews Endocrinology, Published online: 16 July 2025; doi:10.1038/s41574-025-01154-4Adult-onset type 1 diabetes mellitus differs from the early onset form in terms of residual endogenous insulin secretion, comorbidities and baseline cardiorenal risk. Adjunct therapy with glucagon-like peptide 1 receptor agonists could offer benefits in this population of patients by preserving β-cell mass and function while also contributing to cardiorenal risk mitigation.

New content online: The role of GLP1 receptor agonists in adult-onset type 1 diabetes mellitus

‘Landmark’ study: three-person IVF leads to eight healthy children Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria.

Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria

go.nature.com/4nUQHAq