Marcel Diallo

the proteasome still holds secrets – amazing new study shows how midnolin drives ubiquitin-independent degradation, repurposing proteasomal Rpn11 to act as a receptor not a deubiquitinase, while PSMD2 anchors midnolin via its NLS motif. wow. congrats to all authors.
www.biorxiv.org/content/10.1...

Keiji Tanaka (1949–2024) Keiji Tanaka, a beloved scientist and a pioneering leader in the field of intracellular protein degradation, passed away unexpectedly from ischemic heart disease on July 23, 2024 at the age of 75. His unparalleled dedication to proteasome research has left an indelible legacy; without his contributions, the field would scarcely be where it is today. His untimely departure marks a profound loss to life sciences and will be deeply mourned by colleagues and researchers worldwide.

ご冥福をお祈りします。

CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.

The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle!
www.cell.com/molecular-ce...

🔊Registration OPEN NOW: Ubiquitin & Friends Symposium, 8-9 May 2025, in Vienna, Austria.
Fantastic guest speakers👇PLUS open slots for talks from abstracts. Great opportunity for #ECRs!
🗓️Deadline for abstracts & registrations: 7 April 2025
➡️ www.protein-degradation.org/symposium/
#ubfriends2025

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin chain assembly complex (LUBAC). While most E3 ubiquitin ligases conjugate ubiquitin to protein lysi...

Excited to share our latest preprint on @biorxivpreprint.bsky.social: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".

www.biorxiv.org/content/10.1...

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna!
Registration will open🔜 Keep an eye out for the announcement 👀
✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting!
🔗 www.protein-degradation.org/symposium/

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks https://www.biorxiv.org/content/10.1101/2024.11.26.625361v1 DNA-protein crosslinks (DPCs) are endogenous and chemotherapy-induced genotoxic DNA lesions and, if

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks https://www.biorxiv.org/content/10.1101/2024.11.26.625361v1

Could't think of a better inaugural post here. Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology. Congratulations Kim, Kai, and all authors! www.nature.com/articles/s41...

M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic Stress Methionine-1 (M1)-linked ubiquitin chains, assembled by the ubiquitin ligase LUBAC and cleaved by the deubiquitinase OTULIN, are critical regulators of inflammation and immune homeostasis. Genetic los...

Excited to share this work led by @CamillaElb from my lab where we identified an entirely new role of LUBAC as a critical regulator of AMPK, the energetic stress response, and the regulation of cellular metabolism. If you are interested in #ubiquitin and #metabolism, have a read:

Ubiquitin started pack 💪🏾
go.bsky.app/3VPQofn

Would like to be added please

Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute Do you want to be part of a state-of-the-art core facilit

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community:
candidate.hr-manager.net/ApplicationI...