Miami Cubans get it.
05.04.2025 17:49 β π 2 π 0 π¬ 1 π 0
Thousands in Downtown Miami at the Hands-Off protest
05.04.2025 17:39 β π 2 π 0 π¬ 0 π 0
After receiving this score yesterday on our R01 at the National Cancer Institute, I can only express my deepest gratitude to the dedicated, hard-working employees at NIH for all they do!
05.04.2025 12:15 β π 3 π 0 π¬ 0 π 0
Letter found among my late father's papers from his former post-doc mentor
04.04.2025 18:40 β π 2 π 0 π¬ 0 π 0
This Seth approves.
23.03.2025 23:02 β π 907 π 97 π¬ 29 π 10
Amazing job by @paolamanara.bsky.social in her PhD defense this morning. Congratulations Dr. Manara, PhD.
24.03.2025 17:04 β π 2 π 0 π¬ 0 π 0
Major Congratulations to Schatz lab graduate Caroline Coughlin matching Friday at her No. 1 choice for residency!! @bostonchildrens.bsky.social
24.03.2025 17:01 β π 2 π 0 π¬ 0 π 0
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
This will have tragic consequences on medical research. #NIH ban on renewing senior scientists adds to assaults on its in-house research | Science | AAAS www.science.org/content/arti...
27.02.2025 18:41 β π 6 π 2 π¬ 0 π 0
Our grad student Olivia Lightfuss' confocal microscopy images displayed in our Office of Graduate Studies. Nice work Liv! @austinnewsam.bsky.social @paolamanara.bsky.social
27.02.2025 15:06 β π 2 π 0 π¬ 0 π 0
Study section I was scheduled to serve on Thursday and Friday this week, countless hours spent in preparation by me and the rest of the members, canceled today with no explanation given. Why would Putin have ordered this?
26.02.2025 01:00 β π 2 π 0 π¬ 0 π 0
With Sylvester Director Stephen Nimer at the 15 Dolphins Cancer Challegne today. 99 miles!
A great way to support Cancer Research in Desperate Times!
dolphinscancerchallenge.com/index.cfm?fu...
22.02.2025 21:31 β π 1 π 0 π¬ 0 π 0
We need a new option. Facing a president systematically destroying their country and whose popularity is low and sinking, they have NOTHING to offer. Democratic cowardice got us into this mess, beginning with Obama (the cowardly lion) and moving forward. They know no other way...
21.02.2025 20:38 β π 0 π 0 π¬ 1 π 0
Flat Earthers? Don't tempt them
21.02.2025 20:32 β π 0 π 0 π¬ 0 π 0
FOIA incoming
21.02.2025 20:29 β π 2 π 0 π¬ 0 π 0
DOGE By The Numbers
theonion.com/doge-by...
21.02.2025 02:00 β π 14325 π 2871 π¬ 184 π 83
He's a parody of himself
03.02.2025 16:37 β π 0 π 0 π¬ 0 π 0
Sylvester Comprehensive Cancer Center
Thanks to the Cutaneous Lymphoma Foundation for listing our multidisciplinary skin lymphoma clinic. This clinic staffed by me and Georgios Pongas from hematology and Scott Elman from dermatology is an incredible resource for patients affected by these diseases!
www.clfoundation.org/sylvester-co...
03.02.2025 15:14 β π 1 π 0 π¬ 0 π 0
BLUETORIAL 6) Read our paper for the fascinating mechanisms of how this all works. Incredible work by our first and many contributing authors over the past several years!
03.02.2025 14:10 β π 0 π 0 π¬ 0 π 0
BLUETORIAL 5) We find, however, that a combination of BTK inhibitor, in particular the potent non-covalent compound pirtobrutinib, and venetoclax overcomes resistance. BTK therefore maintains a role in driving resistance even when CBM is activated downstream by BCL10 mutations.
03.02.2025 14:09 β π 0 π 0 π¬ 0 π 0
BLUETORIAL 4) BCL10 mutations cluster in BN2/C1 DLBCL cases, which are known to be resistant to BTK inhibitors. We find that BCL10 mutations, in addition to driving BTK inhibitor resistance, drive resistance to multiple other classes of drug, including the BCL2 inhibitor venetoclax
03.02.2025 14:07 β π 0 π 0 π¬ 0 π 0
BLUETORIAL 3) Our work now elaborates on the signaling and therapeutic consequences of these activating mechanisms. Detailed gene-expression and mechanistic work shows how mutant-BCL10 mediated CBM activation establishes a cytokine-reinforced positive-feedback loop of lymphomagenesis
03.02.2025 14:04 β π 0 π 0 π¬ 0 π 0
BLUETORIAL 2) Amazing work by the Ari Melnick lab demonstrated both these classes of mutation activate the protein's role in signaling by way of the BCL10-CARD11-MALT1 (CBM) complex. R58Q stablizes signaling, the truncations remove an inhibitory domain allowing spontaneous complex activation.
03.02.2025 14:01 β π 0 π 0 π¬ 0 π 0
Bluetorial 1) BCL10 is recurrently mutated in DLBCL cases with a fascinating pattern: The N-terminal CARD domain has a hotspot missense mutation (R58Q) consistent with gain of function, while the C-terminal is recurrently truncated consistent with loss of function.
03.02.2025 13:59 β π 0 π 0 π¬ 0 π 0
Writer/reader/speaker/music lover/book reviewer (NPR, Locus, etc)/freelancer/photographer/PhD/New York Times horror columnist. Words in many places. I want to do all the things, so invite me!
https://linktr.ee/gabinoiglesias
Dad, husband, President, citizen. barackobama.com
ASH Hematology's newest launch delivering innovative, bite-sized learning experiences for hematologists.
https://linktr.ee/ash_hematology_edu
Executive Editor/Team Leader Open Access Science Journals Sage Publishing
Opinions = mine
http://linkedin.com/in/jlovick-editor
#oncology #cancerresearch #medicine #biology #cardiology #neurology #microbiology #publichealth #healthcare #technology
U.S. Senator from Connecticut.
Husband, dad, veteran, writer, and proud Midwesterner. 19th US Secretary of Transportation and former Mayor of South Bend.
Husband and father. Proudly serving as Illinoisβ 43rd governor.
Policy wonk, public servant, liberal, Indian American, mom, wife. Not in that order.
Feel lucky to serve Pres Biden and VP Harris.
The leukemia and lymphoma society is a scam and are stealing real event companies website through fraud & illegal activities with the help of the ny wipo and icann
Chair of the Department of Hematology UMC Utrecht, NL, and Principle investigator interested in biology of gdT cells and allogeneic stem cell transplantation.
We educate the next generation of engineering leaders.
We study infant social behavior
Directed by @simpson.bsky.social, Psychology Department @UMiamiPsych.bsky.social, University of Miami @UnivMiami.bsky.social
https://linktr.ee/socialcoglab
The Climate Resilience Institute supports interdisciplinary, problem-driven research and education to train the next generation and deliver solutions to climate change impacts and other environmental stressors. Founded in 2022.
The Rosenstiel School of Marine, Atmospheric, and Earth Science is one of the worldβs premier education and research institutions.
Translational Cancer Biologist - Passionate about signaling mechanisms, resistance pathways, and novel therapies π§¬π¬ - Yale Postdoc π©πΌβπ¬
Steampunk novelist, channeling Kurt Vonnegut. World weary science editor.
βAll moments, past, present and future, always have existed, always will exist.β
So it goes.
Oxford University Department of Physiology, Anatomy and Genetics
