Dan Liebler

“Tell your children who the cowards were.”

The antibodies don’t work! The race to rid labs of molecules that ruin experiments Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.

The antibodies don’t work! The race to rid labs of molecules that ruin experiments

Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.

www.nature.com/articles/d41...

Let's see how that government ban on White House demolition photos is going.

www.pbs.org/newshour/pol...

Vanderbilt response to the Trump ‘compact’ is too clever by half. Dodging the immoral dominance play and pretending it’s a reasoned conversation. Vandy wishes to play ball as an elite institution on a level with MIT, Penn and UVA. Struck out looking.

I repeat myself: this is a town of 6000 people in Waldo County, Maine

1700 people out for No Kings in rural Rockland, Maine today… more than 4% of the population of Knox County.

#NoKings #Maine #MEPolitics

#NoKings rally Rockland Maine

Speculation: There has been a recency bias in citations for a long time, because the newer work should contain more up-to-date knowledge.

This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.

These shape-shifting rings create customizable cores 1,2-oxaborines can shift into 11 different ring shapes to make modifying molecular cores easy

Turns out, boron-based heterocycles are anything but boring! In fact, some of them are pretty magical...1,2-oxaborines, for example, can be used as precursors to 11(!) other ring systems!

Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...

People need to start highlighting that Miller is actually the shadow President and the one calling the shots. When it was Musk who was doing it, it caused a rift between them so big that after he was out, Musk was bashing Trump claiming he is in the Epstein files.

True—BUT—setting aside the shameless jerks in the stands, the American players staged a thrilling comeback on Sunday to almost win it. In other words, there was an inspiring comeback that arose from the debacle. That is inspiration for America beyond golf.

Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed.
www.nejm.org/doi/full/10....

Since I’m retired, I’ll take the bait. All measures are by definition quantitative. They differ in performance characteristics (linearity, measurement variation, repeatability, interference, specificity, etc). “Qualitative” is a useless adjective, mainly used as a highbrow insult.

Charger data transparency: Curing range anxiety, powering EV adoption | Brookings Proposal for states to require fast chargers to report real-time status accessible by any EV mapping app, so drivers can reliably navigate to chargers.

Elaine Buckberg: To address "range anxiety," states should enact laws that require fast chargers to report real-time status that any EV mapping app can access via @brookings.edu Hutchins Center. www.brookings.edu/articles/cha...

Well done.

That would require good questions and hypotheses instead of just the same ol’ proteomics numbers race.

70 years ago, on this date, Emmett Till was kidnapped and brutally murdered by white men.

His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary

I just retired, but I think if I were a younger investigator, I’d jump on this area. Mother Nature does not do random PTMs. Great analysis challenge that requires better technology. Great data analysis challenge. Needs better questions and hypotheses. Plenty of room for fresh thinking. Go!!

Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:

Roto

The Bayh-Dole Act has governed government funded university research and commercialization for decades. It provides the framework to enable these advances to be commercialized. Huge success, which drives most of biotech and pharma. Lifesaving.

Quality reps

If you measure and interpret RNA levels in single cells, read this:

"𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙."

1/2

Protein degradation is often considered as a final step in regulating gene expression.

It also regulates the first step: Transcription

Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.

👇

The homeless are painful to look at because they remind us of how unfair our world is, of how much suffering it contains, of how arbitrary and undeserved and precarious our own comforts and health are, of how we have failed to be sufficiently generous and merciful to others.

talkingpointsmemo.com

Widespread Post-transcriptional Attenuation of
Genomic Copy-Number Variation in Cancer

I guess he never heard of pharmacology.

The original sin of plasma proteomics. You get a handful of answers before you even pose a real question. Friends don’t let friends do plasma proteomics.

Those dead eyes