Thinking about EZM2026 in Vienna? 🐟
Travel grants are now open for students & ECRs.
7–11 July 2026 | Deadline: March 15
Hope to see many of you there! @ezsociety.bsky.social #zebrafish
06.02.2026 10:19 — 👍 11 🔁 10 💬 0 📌 0
Mark your calendars for 2027! The best GRC is coming to Europe 🇳🇱
💥 Fertilization and Activation of Development
📍 Noordwijk, Netherlands
🗓️ July 31 - August 6, 2027
www.grc.org/fertilizatio...
Can’t wait!
25.01.2026 19:56 — 👍 12 🔁 3 💬 0 📌 1
In vivo kinetics of protein degradation by individual proteasomes
Protein degradation by the proteasome is central to cellular homeostasis and has been studied extensively using biochemical and structural studies. Despite an in-depth understanding of core proteolytic activity, it has remained largely unresolved how individual proteasomes process substrates inside living cells where many substrate types and co-factors exist. Here, we establish a live-cell single-molecule imaging approach that enables direct visualization and quantification of protein degradation by individual proteasomes. Using this approach, we find that substrate identity, folding and protein-protein interaction have a surprisingly modest impact on processing efficiency, whereas the mode of substrate engagement greatly impacts substrate processing; degradation initiated from protein termini typically proceeds rapidly and with high processivity, whereas internal engagement constitutes a distinct processing mode that exhibits poor processivity and a specific requirement for the AAA+ family ATPase p97/VCP. Furthermore, degradation initiated from opposite termini proceeds with asymmetric rates in a sequence-dependent manner, demonstrating that directionality is an important feature of proteasomal processing in vivo. Notably, poly-glutamine substrates associated with neurodegenerative disease are efficiently degraded from one terminus but resist degradation when engaged from the opposite terminus, highlighting the importance of substrate engagement mode. Together, our results show that different modes of substrate engagement lead to different proteasomal processing outcomes in vivo and revise the prevailing view of the proteasome as a uniform degradation machine. ### Competing Interest Statement The authors have declared no competing interest.
New lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement.
www.biorxiv.org/content/10.6...
20.01.2026 08:32 — 👍 46 🔁 15 💬 1 📌 2
🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made.
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
19.01.2026 09:40 — 👍 50 🔁 16 💬 1 📌 1
If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!
10.01.2026 11:54 — 👍 19 🔁 4 💬 0 📌 0
If you want to become an expert in #zebrafish research, apply for the 2026 Zebrafish Development & Genetics course! You will be working in small groups taught by leaders in the field, which can be a transformative experience!
Application deadline: March 2
www.mbl.edu/education/ad...
03.01.2026 09:01 — 👍 8 🔁 7 💬 0 📌 1
Course Offerings | Marine Biological Laboratory
Are you planning your summer ahead and are interested in immersing yourself in some intense weeks of research, science and fun?
Then this might be for you: Check out the amazing summer course offerings @mblscience.bsky.social, including the #Zebrafish course!
www.mbl.edu/education/ad...
03.01.2026 09:01 — 👍 9 🔁 3 💬 1 📌 0
Applications for the 2026 Vienna BioCenter Summer School Program are now open!
Please share this opportunity with talented undergrads or Masters students interested in broadening their research experience in molecular biology in the heart of Europe 🧬
17.11.2025 16:48 — 👍 10 🔁 8 💬 0 📌 0
Very happy to share my postdoc work (on preprint), where we try to understand a long-standing transcription-silencing paradox, and uncovered a hidden RNA decay arm of nuclear piRNA pathway, see detailed threads quoted from @juliusbrennecke.bsky.social
22.12.2025 19:38 — 👍 33 🔁 12 💬 1 📌 0
We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it:
Our work is now out in Nature Communications:
🔗 nature.com/articles/s41467-025-67692-7
22.12.2025 14:38 — 👍 25 🔁 10 💬 2 📌 1
I feel like a parent seeing your first kid leave home ;-).
While the entire Pauli lab family will greatly miss @lorenzoorts.bsky.social as Laura has become a real role model, it makes me incredibly happy & proud to have her establish the Lorenzo-Orts lab at the @imbmainz.bsky.social! All the best!
14.12.2025 20:26 — 👍 41 🔁 3 💬 1 📌 0
Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila
So excited to finally be able to share my first paper and the culmination of my PhD work with @felipekteixeira.bsky.social 🪰🔬
www.pnas.org/doi/10.1073/...
04.12.2025 21:41 — 👍 15 🔁 12 💬 3 📌 2
All the best for becoming the 'Schierleader' yourself for your team! Rooting for you, and am looking forward to seeing what the Reimao Pinto-lab will be up to in the future!
03.12.2025 07:03 — 👍 2 🔁 0 💬 1 📌 0
Big congrats to the entire team from the @beckmannlab.bsky.social and @greenlab.bsky.social, in particular first author Vienna!
23.11.2025 20:52 — 👍 2 🔁 1 💬 0 📌 0
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
23.11.2025 15:46 — 👍 48 🔁 20 💬 2 📌 2
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
19.11.2025 20:23 — 👍 120 🔁 75 💬 1 📌 3
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
21.11.2025 17:36 — 👍 122 🔁 52 💬 1 📌 3
... and we would love to see you ALL - working with ANY fish model - join us in Vienna for www.ezm2026.org, the biggest fish meeting in 2026! We plan to have a special session 'beyond zebrafish' and would love to include talks representing other fish systems across all sessions. Pls spread the word!
21.11.2025 19:23 — 👍 12 🔁 7 💬 2 📌 0
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
14.11.2025 18:38 — 👍 94 🔁 44 💬 3 📌 5
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
10.11.2025 21:30 — 👍 20 🔁 6 💬 0 📌 0
HT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊
🔗 www.embl.org/news/science...
05.11.2025 10:09 — 👍 28 🔁 10 💬 2 📌 0
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
06.11.2025 16:04 — 👍 67 🔁 29 💬 0 📌 1
This Halloween, we have a spooky evolutionary story for you.
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
31.10.2025 10:19 — 👍 88 🔁 43 💬 6 📌 1
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
29.10.2025 14:20 — 👍 37 🔁 13 💬 4 📌 0
Group leader @Institute of Allergy Research @HelmholtzMunich
|| Interested in lymphocyte development, B-cell-mediated responses, molecular immunology || #LatinasinSTEM🇨🇺
PhD student in the Tanenbaum group @hubrechtinstitute.bsky.social
PhD Student in the Phadnis Lab at the University of Utah
PhD student at EMBL Heidelberg
Fascinated about the molecular mechanisms of evolutionary arms races and fast evolving sequences.
Hobby enthusiasts of non-model organisms.
of the arts and sciences
jeremyhollisdesigns.com
campbelllab.org
Understanding development to understand pathologies
Principal Investigator at CeMM and LBI-NetMed: https://rendeiro.group
Computational Biology of Aging and Pathology
Cell metabolism & mitochondria | HFSP-alumni & Postdoc at MSKCC
Postdoc with @HelenWeavers @BristolBiochem 🔬 PhD with @FelipeKTeixeira @GeneticsCam
Interested in stress responses, translational regulation, development 🪰
Scientist who is interested in ubiquitin biology. PI at FBS Osaka University. https://fumiyoikeda-lab.com/
The official Bluesky account of the European Zebrafish Society - supporting and connecting the zebrafish research community across Europe. Updates on events, training, resources, and community initiatives.
PhD student studying DNA replication🧬 in Yeeles group at MRC-LMB
Developmental neurobiologist studying the adult brain. Group leader @IMBA, Vienna. Quiescence, adult neurogenesis, fate transitions.
The Institute of Science and Technology Austria (ISTA) is dedicated to cutting-edge basic research and graduate education.
www.ista.ac.at
Research group leader @mpi-mp-potsdam.bsky.social
Interested in virus-plant interactions, especially those involving vertical virus transmission from parent to progeny and stem cell antiviral immunity. All posts are my own.
We study how organisms grow, age & develop disease through basic research in epigenetics, genome stability & related fields 🧬
www.imb.de / Imprint: https://www.imb.de/impressum-imprint
📍 #Mainz, Germany
SNSF Ambizione junior group leader @UZH - fascinated by how embryos get their shapes and patterns 🐠
Postdoc @ Pelkmans lab | PhD @ Heisenberg lab
Developmental biologist | Postdoc @Biozentrum Basel (Schier lab)
