Pedro Latorre-Muro

Congrats!

Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social

Thanks to everyone involved!

www.cell.com/cell-metabol...

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity - Nature Cell Biology Latorre-Muro et al. show that the cytosolic chaperone PPID drives insertion of the mitochondrial import receptor TOM70 into the mitochondrial outer membrane, thereby regulating body temperature, gluco...

💫NEW by @ppuigserverb.bsky.social & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice.
👉https://rdcu.be/d8atv
www.nature.com/articles/s41...

Very exciting findings @ppuigserverb.bsky.social connect mitochondrial ETC deficiencies with cancer cell immunogenicity expanding the repertoire of strategies to target tumor vulnerabilities

New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ

Fine-tuning tumor immunogenicity with mitochondrial complex I - Nature Cancer Targeting mitochondrial metabolic activity is an active area of cancer research. A study now finds that a selective deficiency in mitochondrial complex I in melanoma cells increases mitochondrial acet...

Thanks to Désirée Schatton and Christian Frezza @frezzalab.bsky.social for the great News and Views @naturecancer.bsky.social
www.nature.com/articles/s43...

Thanks, Melanie!

Thanks, HaGe!

Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders

The human zinc-binding cysteine proteome A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.

Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...

Our recent work on mitochondrial respiratory complexes @platorremuro.bsky.social highlighted in the DFCI Inside blog- Thanks to the Dana-Farber Editorial team for written this blog @danafarber.bsky.social
blog.dana-farber.org/insight/2024...

Structural basis of respiratory complex adaptation to cold temperatures High-resolution structures of respiratory I:III2 complexes from brown fat adapted to cold temperatures reveal a distinct supercomplex assembly with rotated CIII2 that displays higher electron transfer...

In the latest issue of Cell- Structural basis of respiratory complex adaptation to cold temperatures