Felix Mikus's Avatar

Felix Mikus

@fmikus.bsky.social

Postdoc @Dudin lab, UNIGE Previously EMBL HD Lots of microscopy of all different things. If it’s not big enough, make it bigger #UExM Views my own

617 Followers  |  562 Following  |  31 Posts  |  Joined: 11.09.2023  |  2.0572

Latest posts by fmikus.bsky.social on Bluesky

Researcher Florian Wollweber standing next to a cryo-focused ion beam microscope in a laboratory, with technical infrastructure visible in the background.

Researcher Florian Wollweber standing next to a cryo-focused ion beam microscope in a laboratory, with technical infrastructure visible in the background.

The origin of eukaryotic cells continues to be one of the greatest mysteries in biology.

EMBL Grenoble is excited to welcome Florian Wollweber, who will use cutting-edge imaging techniques to study Asgard archaea — microbes closely related to our earliest ancestors. 🦠🔬

www.embl.org/news/people-...

28.01.2026 10:56 — 👍 86    🔁 20    💬 4    📌 0

And @veslemoykaen.bsky.social joining from far away Lausanne

22.01.2026 20:47 — 👍 0    🔁 0    💬 0    📌 0

It was a really fun couple of weeks in the lab !
I also very much enjoyed being in full handle of the #Zeiss 3Dsim scope provided generously for us to explore the various samples.

22.01.2026 18:17 — 👍 19    🔁 3    💬 0    📌 0

This is part of our ExÂME project between @dudinlab.bsky.social @gautamdey.bsky.social Tom Richards and @moorefound.bsky.social

22.01.2026 17:18 — 👍 3    🔁 0    💬 0    📌 0

The selection of samples was incredibly diverse, both across size but also across the tree. Thanks for being a fantastic bunch! Hope it will advance your research questions!
@alfredolpsousa.bsky.social @alinaks.bsky.social @godi.bsky.social @tvasilj.bsky.social
Give them a follow if you haven’t!

22.01.2026 17:18 — 👍 4    🔁 1    💬 2    📌 0
The Dudin lab and their expansion visitors having some well deserved friday drinks and games

The Dudin lab and their expansion visitors having some well deserved friday drinks and games

A group of visitors in their lab coats busily working to get their cells and tissues expanded, stained and ready for microscopy

A group of visitors in their lab coats busily working to get their cells and tissues expanded, stained and ready for microscopy

Over the last two weeks the Dudin Lab expanded two-fold and it’s been a blast!
We are hosting a group of amazing visitors that stopped by with their own species and samples to get started with expansion microscopy.
It was a ton of fun, very much looking forward to pictures to come ❤️
#ExpandThemAll

22.01.2026 17:18 — 👍 30    🔁 5    💬 1    📌 3
Preview
Imaging spotlight: U-ExM atlas of microbial eukaryotes - FocalPlane Imaging spotlight: U-ExM atlas of microbial eukaryotes - News

🔬🔦Our Imaging spotlight from @hiralshah.bsky.social & team highlights their U-ExM atlas of planktonic eukaryotes, including details on how you can explore this wonderful resource. Plus, check out Hiral’s top tips on getting started with expansion microscopy.
focalplane.biologists.com/2026/01/20/i...

20.01.2026 13:26 — 👍 22    🔁 11    💬 0    📌 2
Post image

On this day in 2021, I landed in a snowy, lockdown-silenced Heidelberg to start my lab. 5 years later we are a force to reckon with in our field, and the first generation are striking out on their own. I couldn’t be more proud, & grateful to them and our wonderful collaborators around the world 🌍 🧪

07.01.2026 10:08 — 👍 142    🔁 9    💬 6    📌 0
Post image

Another #notTHECover unfortunately.

But this gorgeous, Tron-like vibe, drawn by the amazing @munafomarzia.bsky.social for our recent #ExM work with @gautamdey.bsky.social & @centriolelab.bsky.social will still be printed out in the lab.

Read here: www.cell.com/cell/fulltex...

26.12.2025 11:53 — 👍 100    🔁 19    💬 4    📌 2

We hope that integrating models with data will unlock new predictive capacity for mixotrophs--and beyond. Huge thanks to Ginger for scouting us, and to collaborators @suleles.bsky.social, @gautamdey.bsky.social, @fmikus.bsky.social, Julian Jacobs, and Kevin Archibald for building skills & ideas!

11.12.2025 21:05 — 👍 19    🔁 3    💬 1    📌 0
Post image

We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!

GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.

Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.

👉 www.unige.ch/genexm/

10.12.2025 20:43 — 👍 141    🔁 34    💬 2    📌 0

Preprint alert 🔔 Organosulfur compounds support carbon and energy metabolism in chemosynthetic symbiosis. Happy to see this cool collaboration with @organosulfur.bsky.social and others out 🥳

07.12.2025 10:14 — 👍 13    🔁 3    💬 1    📌 0

So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍

The mighty yeast reveals what we believe are general principles of centromere evolution!

Behind the curtain: communities.springernature.com/posts/counti...

#MEvoSky 🧪🌎

27.11.2025 09:21 — 👍 61    🔁 17    💬 0    📌 2
Post image Post image

Our attempt to give multinucleate cells the spotlight they deserve (seriously, they’re everywhere), led by the fearless @mrosjac.bsky.social and with @Markus Ganter

doi.org/10.32942/X2M...

We’d love your feedback while this goes through the peer review process!

#MicroEvoSky
#ProtistsonSky 🧪🌏

26.11.2025 14:05 — 👍 63    🔁 23    💬 4    📌 2
Post image

How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1

26.11.2025 16:21 — 👍 184    🔁 84    💬 8    📌 8

So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵

25.11.2025 20:41 — 👍 492    🔁 163    💬 16    📌 31

I’m very happy that our paper is now published in Angewandte Chemie! 👏 A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells.
↪️ onlinelibrary.wiley.com/doi/full/10....
Big thanks again to all co-authors (especially Bego) and collaborators for their contributions! 👏

13.11.2025 17:57 — 👍 12    🔁 2    💬 0    📌 0
Post image

New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇

www.biorxiv.org/content/10.1...

13.11.2025 16:20 — 👍 157    🔁 40    💬 0    📌 4
Preview
PhD student in systematic biology The Department of Organismal Biology teaches and explores the evolution, development and function on the organismal level. For more information see Department of Organismal Biology - Uppsala Universit

It is a collaboration between my lab (Uppsala U) and the labs of @dudinlab.bsky.social (Geneva U) and @filiphusnik.bsky.social (OIST). More info and how to apply here:
uu.varbi.com/en/what:job/.... (The use of AI for writing the motivation letter is discouraged and will be regarded unfavourably) 2/2

12.11.2025 09:50 — 👍 20    🔁 9    💬 0    📌 1
Post image Post image Post image

This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy

07.11.2025 13:35 — 👍 77    🔁 21    💬 1    📌 1
Post image

(1/2) A new study from EMBL researchers and their collaborators provides unprecedented insights into the cellular architecture of over 200 species of plankton – tiny but ecologically critical marine organisms – using ultrastructure expansion microscopy.

Learn more: www.cell.com/cell/fulltex...

04.11.2025 08:30 — 👍 39    🔁 14    💬 1    📌 0
Post image Post image

🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!

With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇

01.11.2025 12:41 — 👍 80    🔁 16    💬 1    📌 2
Post image

Excited to share my first PhD student’s @biorxivpreprint.bsky.social!

Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!

Check it out!

www.biorxiv.org/content/10.1...

01.11.2025 05:56 — 👍 85    🔁 25    💬 1    📌 3
Video thumbnail

Exciting day for the lab: our 1rst paper is officially out in @currentbiology.bsky.social 🥳 Wonderful collaboration wt @gautamdey.bsky.social showing how Cryo-ExM achieves consistent immunostaining in diverse diatoms, from the lab and the natural environment 1/n
#ProtistsOnSky
tinyurl.com/2zxaund7

31.10.2025 15:27 — 👍 166    🔁 55    💬 1    📌 2

Our new #ExÂME effort with the @moorefound.bsky.social, is scaling up with T. Richards & @gautamdey.bsky.social : antibody screens, optimized protocols, open-access imaging, and community training--> all toward a shared atlas.

👉 Join us: www.dudinlab.com
#ProtistsOnSky #CellBiology #Evolution

31.10.2025 14:41 — 👍 7    🔁 2    💬 0    📌 0
Preview
Diatom ultrastructural diversity across controlled and natural environments Flori et al. establish high-resolution and generalizable immunofluorescence in cultured and environmental diatoms, thanks to 4-fold cryo-expansion microscopy. This represents a step-change for compara...

And it’s a double feature, as shown by @gautamdey.bsky.social ial & @floravincent.bsky.social for the sturdy #Diatoms! Also out today in @currentbiology.bsky.social 🌊

www.cell.com/current-biol...

31.10.2025 14:41 — 👍 20    🔁 5    💬 1    📌 1
Video thumbnail

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...

31.10.2025 14:41 — 👍 215    🔁 98    💬 15    📌 11
Preview
Metalog: curated and harmonised contextual data for global metagenomics samples Abstract. Metagenomic sequencing enables the in-depth study of microbes and their functions in humans, animals, and the environment. While sequencing data

Great to see this finally published!

Metalog: curated and harmonised contextual data for global metagenomics samples

now out in @narjournal.bsky.social

academic.oup.com/nar/advance-...

31.10.2025 15:16 — 👍 57    🔁 38    💬 1    📌 2
Practicing some key steps of the expansion microscopy protocol w

Practicing some key steps of the expansion microscopy protocol w

It was a pleasure having so many people interested in learning expansion - even if the images did not look amazing

09.10.2025 11:29 — 👍 3    🔁 0    💬 0    📌 0
Marine doing the heavy lifting and transporting a dry shipper with many plunge frozen samples

Marine doing the heavy lifting and transporting a dry shipper with many plunge frozen samples

Trip 3 and past the 100 species count! Thank you for hosting us in České Budějovice Julius and Galina (and everyone providing samples!), for the prime support, and a fantastic selection of cultures!
#expandthemall @moorefound.bsky.social @dudinlab.bsky.social @gautamdey.bsky.social & T. Richards

09.10.2025 11:29 — 👍 10    🔁 1    💬 1    📌 1

@fmikus is following 20 prominent accounts