Alessandro 🌈

Thanks for sharing @piatkevich.bsky.social! 💡 These red calcium indicators and more are featured in our Fluorescent Protein Biosensors Collection: www.addgene.org/fluorescent-...

No clear evidence to support any link between maternal acetaminophen (Tylenol) intake and autism or ADHD in offspring, a new umbrella, systematic review
@bmj.com

Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated ...

The new Ground Truths today is based on an important paper just published @nataging.nature.com

www.nature.com/articles/s43...

not using ian's secure shoelace knot is a sign of a weak moral character, poor constitution, and an unserious attitude towards quality workmanship

sorry but it's really funny that the same type of centrist pundit freaks who are like "mamdani won't make good on his campaign promises so DON'T vote for him!" were the same ones who said "trump won't make good on his campaign promises so it's fine if he wins"

Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...

We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

The importance of basic research
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm

www.nature.com/articles/d41...

🧠✨ Genetic Tools Atlas 3.0 is here!

The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.

🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas

#neuroskyence

Live cell ACTIN imaging has never been easier with SPY650-FastAct_X!

1. Add the probe to the cells
2. Image 1h later

SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.

image credits: @stephanlab.bsky.social

Spectacular time-lapse image of Comet Lemmon (C/2025 A6), taken by astrophotographer Michael Jäger.

There might have been, um, a few satellites passing by during the long exposure. 🧪🔭

forum.vdsastro.de/viewtopic.ph...

Nanosensors for real-time intracellular analytics - Nature Nanotechnology This Review provides insights into nanosensor technologies for monitoring cellular biomarkers, proposing a spatial framework to clarify their distinct advantages, challenges and performance for high-r...

www.nature.com/articles/s41...

Physics teachers! This E and B field game is fantastic. By Mr Gravell:
#iTeachPhysics
#Science 🧪

scratch.mit.edu/projects/183...

So the US military is privately funded now? Trump’s friend is gonna pay the military. Who do you think the military will be loyal to then? This is insane.

blog.addgene.org Click Biology: How to Click and Play to Explore Biology

Not clickbait 🖱️ build and explore proteins and other biological components faster than ever! Professor Mark Howarth defines Click Biology — standards for building biological tools that’s analogous to Click Chemistry — in our latest blog post! @HowarthSci

First proof of synthetic DNA-encoded antibodies vs SARS-CoV-2 with expression lasting at least 72 weeks from 1-dose, scalable vs other pathogens www.nature.com/articles/s41...

NOW WOULD BE A GOOD TIME TO TAKE DOWN FAT SATAN AND HIS MINIONS‼️

NOBODY IS GOING TO COME AND SAVE US, WE HAVE TO SAVE OURSELVES‼️‼️‼️

THE ONLY WAY TO STOP THEM IS TO SHUTDOWN COMPLETELY‼️

BY SIGNING UP HERE👇🏻👇🏻👇🏻

generalstrikeus.com

States have to step up because the rethuglicans won’t help.

SynapseNet is a deep learning based software tool that automates the segmentation of vesicles, mitochondria, synaptic compartments, and the active zone. This is visualized in three panels. On the left, a section of an electron tomogram with a synaptic compartment densely filled with vesicles, which appear as round structures with dark boundary and light body in the image, is shwon. The top right panel shows the segmentation result of vesicles, visualized by masks with an individual color per vesicle and outlines for the segmented compartment (red) and active zone (blue). The bottom right panels shows a 3D rendering of the segmentation with vesicles shown as yellow spheres.

Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

Structure of riboflavine

Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)

This is fantastic!

Volumetric imaging of 384 wells in a contact free format using an air lens.

Importantly, the 3D imaging remains diffraction limited and distortion-free, despite the large refractive index mismatch from air to water.

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

Introducing CellTransformer, a new AI tool developed with UCSF that makes it easier to explore massive neuroscience datasets and identify important subregions of the brain. 🧵

Figure 1: Fluorophore intensity in the Drosophila blastoderm (n.c. 14). Comparison of (A) green and (B) red fluorescence intensity using the same intensity scaling in n.c. 14. The fluorescence signal did not saturate. Shown are single imaging planes. Normalised histograms of fluorescence intensity for green (C) and red (D) fluorophores averaged across at least n=3 embryos per line. Scale bars = 20 μm

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

blog.addgene.org Exploring Applications of the Bioluminescent HiBiT Tag

HiBiT takes split-luciferase assays to a whole new, highly-sensitive level! 💡 Read about the many applications enabled by HiBiT in this guest blog from our friends at @promegacorporation.bsky.social

ODX: A Fitness Tracker-Based Device for Continuous Bacterial Growth Monitoring Continuous monitoring of bacterial growth in aqueous media is a crucial process in academic research as well as in the biotechnology industry. Bacterial growth is usually monitored by measuring the op...

3/3 The complete design files, firmware, and mobile application are available as open source under GPL 3.0 license at lnkd.in/eSq-asPH
Here is the ink to the ODX paper: doi.org/10.1021/acs....
The corresponding tweet that went viral is here:
x.com/VarunKothama...

Statistics for Biologists: link back to a still highly relevant/useful collection of Nature Methods articles - a one-stop shop for stats tutorials:
www.nature.com/collections/...

1/6 🧵 I'm building what might be the smallest #opensource #spectrometer with an easy to use UI! I call it a pocket spectrometer. Combining #M5StickC (~$20) with AS7341 sensor (~$16). My goal? A complete spectrometer that is barely larger than a sample cuvette itself.

Cell Line Catalog The cell line catalog provides a listing of our completed cell lines, as well as those in progress.

Browse our entire catalog of cell lines and plasmids!

🧫🔬 Stem Cells: www.allencell.org/cell-catalog...
🧠📈 Brain Science: www.addgene.org/The_Allen_In...