Tuan Bui

Pubmed is down and i pray it is a technical rather than political issue. This could be a serious setback for basic and applied research

If you're interested in spasticity, we've just published a reliable way to optogenetically induce hindlimb spasticity after spinal cord injury. All the credit goes to PhD graduate Sara Goltash and postdoc @alaliberte.bsky.social

www.sciencedirect.com/science/arti...

Forgot to say that it's excellent work, as usual, from @mcapogrosso.bsky.social CJ, David, and Amr and the rest of the team.

Pharmacological blocking of spinal GABAA receptors in monkeys reduces sensory transmission to the spinal cord, thalamus, and cortex Mahrous et al. examine the controversial role of GABAARs in sensory transmission in the monkey cervical spinal cord. They find that blocking spinal GABAARs reduces sensory input to both motoneurons an...

More compelling evidence that axoaxonal GABA release in the spinal cord can increase sensory transmission. Cell Reports www.cell.com/cell-reports...

Wishing everyone a Happy Tet! Lots of good health and prosperity for the new year

Mapping of dI3 neuron sensorimotor circuits across the cervical and lumbar spinal cord From the fine control of hand movements to the dynamic corrective adjustments during locomotion, spinal circuits integrate descending supraspinal and sensory inputs to modulate diverse motor functions...

Preprint from the lab (a bit late in announcing). First-year graduate student, Shahriar Nasiri, with a detailed optogenetic mapping of dI3 neuron circuitry within and between cervical and lumbar spinal cord

www.biorxiv.org/content/10.1...

Chuffed to bits about my visit to the Manitoba Neuroscience Network today. Can't wait to see old friends and make new ones, and to catch up on all the excellent neuroscience happening at the University of Manitoba. Will also have a word about them joining Blue Sky!

Developmental changes in the control of primary motoneuron excitability by the M-current in larval zebrafish Spinal circuits for locomotion undergo maturation during early development. How intrinsic properties of individual spinal neuron populations change throughout motor maturation is not fully understood....

Preprint about the development of the M-current in primary motoneurons in zebrafish. Great work by PhD student, Stéphanie Gaudreau, and she's already gotten some more data to go along with this story but an updated version to come sometime in Winter 2025

www.biorxiv.org/content/10.1...

Our department (BIO, University of Ottawa) is hiring for a Canadian Research Chair Tier 2 position in Multicellular Systems and Modelling with a focus on mechanisms of brain and cardiovascular systems
Please send me a DM for more info!

www.nature.com/naturecareer...

I did not realize how liberating it would feel to move to Blue Sky