Raluca Groza

Cells drastically downregulate mRNA translation to save energy during stress. A study by the Weis lab (IBC) shows that mRNAs transcribed after stress escape repression while pre-existing mRNA don’t, in a timing mechanism that is independent of mRNA sequence. More: biol.ethz.ch/en/news-and-...

Biomedical and life science articles by female researchers spend longer under review Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...

Interesting study about the gender gap in publishing. Not sure if 7% longer review time for female scientists is really something, but I do know that indeed we must prove competence more than our male counterparts journals.plos.org/plosbiology/...

"AI swarms are … equipped to exploit this by engineering a synthetic consensus …" Schroeder et al.

In a new #SciencePolicyForum, researchers discuss the risks of malicious “#AI swarms,” which enable a new class of large-scale, coordinated disinformation campaigns that pose significant risks to democracy. https://scim.ag/49FIhrM

how expensive is a Gemüse Kebab nowadays?

Whole-genome spatial transcriptomic imaging with RAEFISH Nature Reviews Genetics, Published online: 09 January 2026; doi:10.1038/s41576-025-00926-yIn this Tools of the Trade article, Yubao Cheng discusses the development of RAEFISH (reverse-padlock amplicon-encoding fluorescence in situ hybridization), a method that enables spatial transcriptomics with both single-molecule spatial resolution and genome-wide coverage.

FYI: New online! Whole-genome spatial transcriptomic imaging with RAEFISH

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex...

TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments.

More below 👇

Left panel: Immunofluorescent microscopy showing that Mtch mutant intestine cells (blue nuclei that lack red dye) fail to clear mitochondria marker protein ATP5A (green). Right panel: Transmission electron microscopy image of a mitochondrion engulfed by an autophagosome of a Drosophila intestine enterocyte.

Mitophagy is critical for cellular health & associated with multiple diseases. @baehreckelab.bsky.social &co show that the OMM protein Mtch regulates #mitophagy during #Drosophila intestinal development, by modulating the insertion of mitophagy receptor BNIP3 @plosbiology.org 🧪 plos.io/45uyBhg

Associations between preservative food additives and type 2 diabetes incidence in the NutriNet-Santé prospective cohort - Nature Communications Exposure to twelve widely used preservative food additives are associated with a higher incidence of type 2 diabetes in the French NutriNet-Santé cohort of 108,723 adults, supporting recommendations to favour fresh and minimally processed foods

A study published in Nature Communications reveals that exposure to certain food preservatives, including potassium sorbate and sodium nitrite, correlates with a higher risk of developing type 2 diabetes. 🧪

The Microscopists | Uri Manor (UC San Diego School of Biological Sciences) In this episode of The Microscopists, Uri Manor, Assistant Professor of UCSD, opens up about growing up with profound hearing loss and how, despite wanting nothing to do with becoming a scientist, ...

Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...

Self-renewal of neuronal mitochondria through asymmetric division Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

#spatialgeneexpression
#RNAlocalizatiom
#RNAsky
www.nature.com/articles/s41...

Parkinson’s breakthrough could unlock treatments for devastating disease Scientists have developed a groundbreaking new technique to visualise the brain clusters that may trigger Parkinson’s

A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression Nature Methods - Spotiflow uses deep learning for subpixel-accurate spot detection in diverse 2D and 3D images. The improved accuracy offered by Spotiflow enables improved biological insights in...

Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)

YouTube video by Prof. Jean Fan RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data

What is RNA velocity in situ? ChatGPT kept getting it wrong...

So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0

#AcademicSky

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!

#Mito #Mitochondriac

go.bsky.app/J6Bu5fL

Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...

Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

check out Nadja’s beautiful work on cytokinesis, many congratulations 👏👏

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/...

#Cytoskeleton #Biochemistry #Mitochondria #septins

Join us at the LS2 Annual Meeting 2026 in Zürich!

😂😂

that looks great, too bad I missed it this time

many congratulations for such beautiful work André and co👏👏

Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...

www.biorxiv.org/content/10.1...
Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social
bit.ly/4l93AUW

Switchable RNA motifs for dynamic transcriptional control of RNA condensates Abstract. RNA-driven phase separation is emerging as a promising approach for engineering biomolecular condensates with diverse functionalities. Condensate

We demonstrated how to make and dissolve #RNA #condensates through strand displacement using synthetic genes - excited to see this new paper out in @narjournal.bsky.social Collab w/ the Andersen group @esandersen.bsky.social academic.oup.com/nar/article/...

Die Kürzungen sind ein absoluter Skandal, die Wissenschaft ist eine der grossen Stärken Berlins. Wir sidn eine der Besten Unis Deutschlands mit vergleichsweise wenig Mitteln, diese noch zu kürzen ist Wahnsinn. Wie sollen wir kompetitiv bleiben? Eine Abwärtsspirale droht.

Come all next week to the online seminar on "Imaging for Cell Biology" of the @dgz.bsky.social
Tuesday June 24th at 12:00 on zoom, info see below.