Raluca Groza

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression Nature Methods - Spotiflow uses deep learning for subpixel-accurate spot detection in diverse 2D and 3D images. The improved accuracy offered by Spotiflow enables improved biological insights in...

Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)

YouTube video by Prof. Jean Fan RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data

What is RNA velocity in situ? ChatGPT kept getting it wrong...

So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0

#AcademicSky

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!

#Mito #Mitochondriac

go.bsky.app/J6Bu5fL

Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...

Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

check out Nadja’s beautiful work on cytokinesis, many congratulations 👏👏

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/...

#Cytoskeleton #Biochemistry #Mitochondria #septins

Join us at the LS2 Annual Meeting 2026 in Zürich!

😂😂

that looks great, too bad I missed it this time

many congratulations for such beautiful work André and co👏👏

Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...

www.biorxiv.org/content/10.1...
Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social
bit.ly/4l93AUW

Switchable RNA motifs for dynamic transcriptional control of RNA condensates Abstract. RNA-driven phase separation is emerging as a promising approach for engineering biomolecular condensates with diverse functionalities. Condensate

We demonstrated how to make and dissolve #RNA #condensates through strand displacement using synthetic genes - excited to see this new paper out in @narjournal.bsky.social Collab w/ the Andersen group @esandersen.bsky.social academic.oup.com/nar/article/...

Die Kürzungen sind ein absoluter Skandal, die Wissenschaft ist eine der grossen Stärken Berlins. Wir sidn eine der Besten Unis Deutschlands mit vergleichsweise wenig Mitteln, diese noch zu kürzen ist Wahnsinn. Wie sollen wir kompetitiv bleiben? Eine Abwärtsspirale droht.

Come all next week to the online seminar on "Imaging for Cell Biology" of the @dgz.bsky.social
Tuesday June 24th at 12:00 on zoom, info see below.

Cell scientist to watch – Francesca Bottanelli ABSTRACT. Francesca Bottanelli is an Assistant Professor in the Department of Biochemistry at Freie Universität Berlin (Germany). Francesca graduated in Plant Biotechnology from the University of Mila...

Thank you @jcellsci.bsky.social, Sara Morais da Silva and Co for highlighting me as “cell scientists to watch”! It means a lot to me and I feel so honored as you guys are such a great community of amazing cell biologists! journals.biologists.com/jcs/article/...

The Hidden Social Lives of Mitochondria When these energy-giving organelles thrive, so do we

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell

great work by Martin Picard

www.scientificamerican.com/article/why-...

😂

The 2025 version of Biomembrane Days is online for registration! Sign up now, it is going to be spectacular as always! Looking forward to an outstanding lineup of speakers both invited and selected. We look forward to having experts in the Cell Biology and Biophysics of membranes!

Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists!
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...

☕Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with #Alzheimers. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology.
bit.ly/4lSORPV

Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...

young neurons, DIV7 🤩

Happy #FluorescenceFriday! Here are some (sm)FISHy iNeurons imaged on a spinning disk🐠 magenta: mitochondria, cyan: GAPDH mRNA, yellow: Map2

Mitochondria in the Nervous System The brain is a high energy-demanding tissue with an heterogenous cellular composition. Most of the energy consumed is used for maintenance of neuronal synaptic transmission, and neurons almost exclus…

Mark your calendar to learn about pleiotropic roles of #mitochondria in neurons and glia cells. Apply now for EMBO Workshop "Mitochondria in the Nervous System" in Engelberg, Switzerland, 28 September–2 October

Deadline: 30 May

meetings.embo.org/event/25-mit...
#EMBOmitoNervousSys #EMBOevents 🧪

🤣 have fun with them! knock them out!

thank you very much! 🤩