Ryan Townley

Smart! Raven loves winning Tic Tac Toe.

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...

FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN Adopting intensive lifestyle changes can slow or stop progression of early-stage Alzheimer’s disease, according to a new study.

FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN www.cnn.com/2025/07/...

Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis Although 10 000 steps per day can still be a viable target for those who are more active, 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a mor...

What's the optimal number of steps of physical activity this is associated with multiple (9) favorable outcomes?
The largest, systematic review of 57 studies, 35 cohorts.
7,000 steps is clinically meaningful, benefit also seen for 4,000 steps cf 2,000 steps
thelancet.com/journals/lan...

I seriously think the Social Internet is 21st century cigarettes. Complete with secondary smoke causing a lot of harm in nonusers.

This fits with my theories here of dementia being a multiple hit hypothesis and structural changes over a decade before lay the groundwork for brain failure in the setting of cognitive/systemic stressors.

Amazing thread.

Trump has shown us on countless occasions that he has no shame.

It’s more troublesome that there are enough like minded individuals he has surrounded himself with to propagate this metastatic hate.

“A society grows great when old men plant trees whose shade they know they shall never sit in.”
— Greek proverb

Interesting. I prefer the hypothesis that APOE4 has more CAA and disrupts BBB enough that more drug gets into the CNS than those without APOE4.

If we could accurately measure BBB integrity we could tweak doses to reduce side effects.

Or we just wait for the transferrin shuttle version :)

Timeline cleanser

Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function
www.science.org/doi/10.1126/...

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

Read our full statement calling on Sec. Kennedy to stop spreading harmful Alzheimer’s myths: bit.ly/43dRIKw. 4/4

Biological markers and psychosocial factors predict chronic pain conditions - Nature Human Behaviour Fillingim et al. show that biological and psychosocial factors jointly predict conditions associated with chronic pain.

🔥 Most important paper I've read all year🔥
👉 Injury/disease doesn't reliably predict pain
👉 Biomarkers alone can't explain pain
👉 PSYCHOSOCIAL factors reliably determine chronic pain
👉 Painful conditions can be predicted from the SYNERGY btwn bio + psychosocial factors
www.nature.com/articles/s41...

Exciting! I know uses/cost will vary for UK but we did put together two related CME pieces:

Biomarker training: kuadrc.org/bhb-training

For more comprehensive cognitive evals (putting ptau217 into greater context) see my series:

PCP training: kuadrc.org/pcpguidebook

I just really need everybody to understand that everything that’s happening in and to the global economy now (and all the businesses and people in it) is the entirely predictable result of the intentional decisions of one guy who doesn’t understand how the global economy works.

Nightmare fuel

The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases
A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social

Catch probability? You wouldn’t believe me.

Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.

New images could change cancer diagnostics, but ICE detained the Harvard scientist who analyzes them Without scientist Kseniia Petrova’s expertise, no one can fully unlock the data’s potential, putting crucial advancements in early cancer detection at risk.

Almost every line of this story would have been simply unbelievable a few months ago:

—Pioneering cancer researcher;
—*Arrested* at airport in Boston;
—Now indefinite ICE detention in Louisiana;
—"Crime": not declaring some frog-embryo samples for research.

Read it.
www.nbcnews.com/news/us-news...

Personally, I think it should be front page news for at least a month if a sitting US President is using falsified evidence to try and deny due process to a man who has committed no crime, but that’s just me

We've seen videos like this before, but usually when you see a tearful wife pleading with the kidnappers who have taken her husband, she's not talking to the U.S. president

They aren’t looking hard enough 😂

The reluctance to diagnose DLB on its own, even when a patient meets full criteria, is baffling to me. I see it often as a 2nd/3rd opinion referral.

Board certified in neurology (ABPN) and BNNP certified - behavioral neurology and neuropsychiatry = wide gap!

It’s diagnosed in our clinic:

1. Amnestic dementia with RBD and hallucinations +/- Parkinsonism
2. Multidomain dementia with DLB criteria and hippocampal atrophy
3. Biomarker positivity for AD/DLB

ICD10: major neurocognitive disorder d/t multiple pathologies. Then list AD and DLB underneath

US scientists create most comprehensive circuit diagram of mammalian brain The 3D map of a cubic millimetre of mouse brain reveals half a billion synapses and 5.4km of neuronal wiring

“Inside that tiny speck is an entire architecture like an exquisite forest..." 🧠❤️
#neuroskyence

www.theguardian.com/science/2025...

Lifestyle matters!!

KU has put together our LEAP (Lifestyle Enrichment for Alzheimer’s Prevention)

www.kumc.edu/research/alz...

The United States Government has no legal authority to snatch a person who is lawfully present in the United States off the street and remove him from the country without due process. The Government's contention otherwise, and its argument that the federal courts are powerless to intervene, are unconscionable.

The Fourth Circuit is famously succinct. storage.courtlistener.com/recap/gov.us...

#corgi focus

The penguins are globalists and rich liberal elitists. Just look how they’re dressed.